piperidines has been researched along with Gangliosidoses* in 2 studies
2 other study(ies) available for piperidines and Gangliosidoses
| Article | Year |
|---|---|
Design and synthesis of 2-acetamidomethyl derivatives of isofagomine as potential inhibitors of human lysosomal beta-hexosaminidases.
As part of a program towards the development of specific inhibitors of human lysosomal beta-hexosaminidase for use as chemical chaperones in therapy of G(M2) gangliosidosis related diseases, the synthesis of 2-acetamidomethyl derivatives of isofagomine has been undertaken. Key event in this synthesis is the conversion of a C-2 substituted gluconolactone derivative into the corresponding lactam, followed by reduction to the corresponding amine. The 1-N-imino-2 acetamidomethyl derivative 5 proved to be a rather selective inhibitor with a K(i) of 2.4 microM for homogenate of human spleen lysosomal beta-hexosaminidase. Topics: beta-N-Acetylhexosaminidases; Drug Design; Enzyme Inhibitors; Gangliosidoses; Humans; Imino Pyranoses; Inhibitory Concentration 50; Kinetics; Lysosomes; Piperidines; Spleen; Structure-Activity Relationship | 2004 |
Liver ganglioside storage after perhexiline maleate.
Topics: Aged; Chemical and Drug Induced Liver Injury; Coronary Disease; Cytoplasm; Gangliosides; Gangliosidoses; Humans; Liver; Male; Middle Aged; Perhexiline; Piperidines | 1977 |