ATP:ADP adenylyltransferase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate. [EC:2.7.7.53]
ATP:ADP adenylyltransferase activity, also known as adenylate kinase, is an essential enzymatic function involved in maintaining cellular energy homeostasis. This enzyme catalyzes the reversible transfer of a phosphate group between adenosine triphosphate (ATP) and adenosine diphosphate (ADP), facilitating the interconversion of these key energy carriers. The reaction proceeds as follows: 2 ADP u003c=u003e ATP + AMP. This equilibrium reaction serves to maintain a balance between ATP and ADP levels within the cell, ensuring an adequate supply of ATP for energy-dependent processes while also preventing excessive accumulation of ADP, which can inhibit cellular function. ATP:ADP adenylyltransferase activity is crucial for various cellular processes, including energy metabolism, signal transduction, and protein synthesis. It is found in all living organisms and plays a vital role in maintaining cellular viability. The enzyme's active site possesses a characteristic nucleotide-binding fold that allows for the specific recognition and binding of ATP and ADP molecules. The catalytic mechanism involves a series of conformational changes that facilitate phosphate group transfer, ensuring efficient and precise regulation of energy flux within the cell.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Lysine--tRNA ligase | A eukaryotic-type lysine--tRNA ligase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15046] | Homo sapiens (human) |
Compounds (7)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| imatinib | aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines | antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor | |
| staurosporine | indolocarbazole alkaloid; organic heterooctacyclic compound | apoptosis inducer; bacterial metabolite; EC 2.7.11.13 (protein kinase C) inhibitor; geroprotector | |
| dehydroabietic acid | dehydroabietate : A monocarboxylic acid anion that is the conjugate base of dehydroabietic acid, obtained by deprotonation of the carboxy group. dehydroabietic acid : An abietane diterpenoid that is abieta-8,11,13-triene substituted at position 18 by a carboxy group. dehydroabietic acid: major aquatic toxicant in effluent of pulp and paper mills | abietane diterpenoid; carbotricyclic compound; monocarboxylic acid | allergen; metabolite |
| crizotinib | crizotinib : A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) Crizotinib: A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER. | 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine | antineoplastic agent; biomarker; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor |
| cladosporin | cladosporin: antifungal metabolite from Cladosporium cladosporioides; toxic, minor metabolite of Aspersillus flavus; inhibits tRNA synthetase in Plasmodium falciparum | ||
| dehydroabietinol | dehydroabietinol: Isolated from Hyptis suaveolens; structure in first source | abietane diterpenoid; carbotricyclic compound | |
| nvp-tae684 | piperidines |