ATP:ADP adenylyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate. [EC:2.7.7.53]

ATP:ADP adenylyltransferase activity, also known as adenylate kinase, is an essential enzymatic function involved in maintaining cellular energy homeostasis. This enzyme catalyzes the reversible transfer of a phosphate group between adenosine triphosphate (ATP) and adenosine diphosphate (ADP), facilitating the interconversion of these key energy carriers. The reaction proceeds as follows: 2 ADP u003c=u003e ATP + AMP. This equilibrium reaction serves to maintain a balance between ATP and ADP levels within the cell, ensuring an adequate supply of ATP for energy-dependent processes while also preventing excessive accumulation of ADP, which can inhibit cellular function. ATP:ADP adenylyltransferase activity is crucial for various cellular processes, including energy metabolism, signal transduction, and protein synthesis. It is found in all living organisms and plays a vital role in maintaining cellular viability. The enzyme's active site possesses a characteristic nucleotide-binding fold that allows for the specific recognition and binding of ATP and ADP molecules. The catalytic mechanism involves a series of conformational changes that facilitate phosphate group transfer, ensuring efficient and precise regulation of energy flux within the cell.'
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Proteins (1)

Compounds (7)