LBD domain binding

Definition

Target type: molecularfunction

Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. [PMID:9682036]

The LBD (Ligand Binding Domain) is a highly conserved domain found in many proteins, particularly those involved in signal transduction. Its primary molecular function is to bind to specific ligands, such as hormones, neurotransmitters, or small molecules. This binding event triggers a conformational change in the LBD, which in turn initiates a cascade of events that ultimately leads to a cellular response. Here's a breakdown of the key molecular functions involved in LBD domain binding:

**1. Ligand Recognition and Binding:**
The LBD possesses a specific three-dimensional structure that allows it to recognize and bind to its cognate ligand with high affinity. This recognition is based on complementary shapes, electrostatic interactions, and hydrophobic interactions between the ligand and amino acid residues within the LBD.

**2. Conformational Change:**
Upon ligand binding, the LBD undergoes a significant conformational change. This change can involve shifts in the positions of amino acid residues, alterations in the overall shape of the domain, or even changes in the relative positions of different domains within the protein.

**3. Signal Transduction:**
The conformational change in the LBD triggers a cascade of molecular events that relay the signal from the ligand to downstream cellular targets. This can involve the recruitment of other proteins, changes in protein-protein interactions, activation of enzymatic activity, or modulation of gene expression.

**4. Biological Response:**
The ultimate outcome of LBD-mediated signal transduction is a cellular response. This response can range from changes in cell behavior, such as growth, differentiation, or migration, to alterations in physiological processes, such as metabolism, immune responses, or neurotransmission.

In summary, the LBD domain binding is a crucial step in signal transduction pathways that control diverse cellular processes. Its ability to recognize ligands, undergo conformational changes, and initiate downstream signaling cascades makes it a vital component of cellular regulation and communication.'
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Proteins (2)

Compounds (144)