Page last updated: 2024-09-27

Axonal Injury, Diffuse

A relatively common sequela of blunt head injury, characterized by a global disruption of axons throughout the brain. Associated clinical features may include NEUROBEHAVIORAL MANIFESTATIONS; PERSISTENT VEGETATIVE STATE; DEMENTIA; and other disorders.

Synonyms(3)

Synonym
Diffuse Axonal Injury
DAI (Diffuse Axonal Injury)
Axonal Injury, Diffuse

Research Excerpts

Overview

ExcerptReference
"Diffuse axonal injury is an uncommon sequel of inflicted head injury in children."( Geddes, JF; Hackshaw, AK; Nickols, CD; Vowles, GH; Whitwell, HL, 2001)
"Diffuse axonal injury is recognized as a progressive and long-term consequence of traumatic brain injury."( Eslami, P; Gabbita, SP; Harris-White, ME; Hensley, K; Hristov, AM; Johnson, MF; Poteshkina, A; Venkova-Hristova, KM, 2016)

Research

Studies (118)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's1 (0.85)12.5806
2000's54 (45.76)18.1394
2010's58 (49.15)28.8240
2020's5 (4.24)9.53
DrugIndicatedRelationship StrengthStudiesTrials
butyric acid0low10
choline0low60
chlorine0low10
creatine0low70
lactic acid0low40
glycine0low10
glycerol0low10
inositol0low20
propionic acid0low10
pyruvic acid0low10
taurine0low10
urea0low10
2-amino-5-phosphonovalerate0low10
3,4-methylenedioxyamphetamine0low10
acetazolamide0low10
amantadine0low10
antipyrine0low10
2-amino-4-phosphonobutyric acid0low10
baclofen0low10
dapi0low10
donepezil0medium11
erythrosine0low10
flumazenil0low20
glyphosate0low10
isoflurane0low10
edaravone0low10
modafinil0low10
apnea0low20
nimesulide0low10
nimodipine0low20
pemoline0low10
4-phenylbutyric acid0low10
potassium chloride0low10
sevoflurane0low10
vigabatrin0low10
corticosterone0low20
estrone0low10
triiodothyronine0low10
aspartic acid0medium111
glutamine0low10
mannitol0low10
valine0low10
isoprene0low10
quinoxalines0low10
meglumine0low10
evans blue0low10
cuprizone0low20
hematoxylin0low10
malondialdehyde0medium11
eosine yellowish-(ys)0low10
cytidine diphosphate choline0medium11
gadolinium0low10
glutamic acid0low90
substance p0low10
n-acetylaspartic acid0medium111
fluorodeoxyglucose f180low70
rosiglitazone0low20
methyllycaconitine0low10
2-(2,3-dicarboxycyclopropyl)glycine0low10
lanthionine ketimine0low10
bq 1230low10
tacrolimus0low20
cannabidiol0low10
curcumin0low10
thiopental0low10
estrone sulfate0low10
fg 90410low10
myelin basic protein0medium41
lysophosphatidylcholines0low10
dextromethorphan0low10
tetrodotoxin0low10
dizocilpine maleate0low10
phosphocreatine0low10
tafluprost0low10
calpain inhibitor iii0low20
pnu-2829870low10
losartan potassium0low10
endothelin-10low30
calpain0low90
piperidines0medium11
interleukin-80low10
minocycline0low10
calpastatin0low10
aconitine0low10
cyclosporine0low10
amyloid beta-peptides0medium21
deoxyguanosine0low10
8-hydroxy-2'-deoxyguanosine0low10
leptin0low10

Protein Targets (899)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
endonuclease IV5005
phosphopantetheinyl transferase9009
TDP1 protein210021
aldehyde dehydrogenase 1 family, member A19009
arylsulfatase A110011
euchromatic histone-lysine N-methyltransferase 2250025
survival motor neuron protein isoform d8008
M-phase phosphoprotein 84004
Metabotropic glutamate receptor 80303
Metabotropic glutamate receptor 60135
Inositol monophosphatase 13003
Metabotropic glutamate receptor 40124
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE120012
Bloom syndrome protein isoform 1140014
peripheral myelin protein 22 isoform 14004
D(1A) dopamine receptor4004
lamin isoform A-delta10200020
Glutamate receptor 11417
Glutamate receptor ionotropic, NMDA 1 012316
Glutamate receptor ionotropic, kainate 30304
Glutamate receptor ionotropic, NMDA 2A 012215
Glutamate receptor ionotropic, NMDA 2B013216
Glutamate receptor ionotropic, NMDA 2C012215
Glutamate receptor ionotropic, NMDA 2D012215
Glutamate receptor ionotropic, NMDA 3B012215
Glutamate receptor ionotropic, NMDA 3A012215
ATP-dependent phosphofructokinase9009
5-hydroxytryptamine receptor 2C0213
5-hydroxytryptamine receptor 2A0224
5-hydroxytryptamine receptor 1A0213
Sodium-dependent noradrenaline transporter 0303
Sodium-dependent dopamine transporter0213
5-hydroxytryptamine receptor 1B0011
5-hydroxytryptamine receptor 1D0011
5-hydroxytryptamine receptor 1F0011
5-hydroxytryptamine receptor 2B0213
5-hydroxytryptamine receptor 60011
Sodium-dependent serotonin transporter0819
Sodium-dependent serotonin transporter0415
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0112
Sodium-dependent dopamine transporter 0808
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0112
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
mitogen-activated protein kinase 17007
Histone deacetylase 30505
Histone deacetylase 40505
Histone deacetylase 10606
Histone deacetylase 70505
Histone deacetylase 20606
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Histone deacetylase 80606
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60505
Histone deacetylase 90505
Histone deacetylase 50505
Chain A, Avidin0022
Chain A, Avidin0022
Chain B, Avidin0022
Chain A, TYROSYL-DNA PHOSPHODIESTERASE8008
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase6006
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase160016
GALC protein4004
GLI family zinc finger 3130013
nuclear receptor subfamily 1, group I, member 3130013
cytochrome P450 family 3 subfamily A polypeptide 49009
glucocorticoid receptor [Homo sapiens]150015
retinoic acid nuclear receptor alpha variant 1170017
retinoid X nuclear receptor alpha100010
estrogen-related nuclear receptor alpha180018
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
thyroid hormone receptor beta isoform a8008
nuclear factor erythroid 2-related factor 2 isoform 1140014
geminin200020
peripheral myelin protein 227007
muscleblind-like protein 1 isoform 16006
Gamma-aminobutyric acid receptor subunit pi94114
ATP-binding cassette sub-family C member 3013013
Multidrug resistance-associated protein 4014014
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Carbonic anhydrase 120215
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump015015
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 104112
Carbonic anhydrase 205112
Carbonic anhydrase 20202
Cytochrome P450 1A20202
Carbonic anhydrase 30215
Cathepsin B0101
Cytochrome P450 3A40415
Steryl-sulfatase0405
Polyunsaturated fatty acid 5-lipoxygenase0202
Cytochrome P450 2C80101
Cytochrome P450 2D60304
Cytochrome P450 2A60202
Cytochrome P450 2C9 0718
Androgen receptor0404
Gamma-aminobutyric acid receptor subunit beta-194114
Translocator protein0101
Gamma-aminobutyric acid receptor subunit delta94114
Gamma-aminobutyric acid receptor subunit gamma-294215
Gamma-aminobutyric acid receptor subunit alpha-594114
Gamma-aminobutyric acid receptor subunit alpha-394114
Cannabinoid receptor 10202
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60213
Carbonic anhydrase 40416
Carbonic anhydrase 60214
Gamma-aminobutyric acid receptor subunit gamma-194114
Gamma-aminobutyric acid receptor subunit alpha-294114
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10101
Dipeptidyl peptidase 40001
Gamma-aminobutyric acid receptor subunit alpha-494114
Gamma-aminobutyric acid receptor subunit gamma-394114
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-694114
Adenosine receptor A2a0202
Delta-type opioid receptor0101
Cytochrome P450 2C190404
Delta-type opioid receptor0101
Mu-type opioid receptor0112
Carbonic anhydrase 5A, mitochondrial0316
Carbonic anhydrase0202
Kappa-type opioid receptor0101
Carbonic anhydrase 70214
Carbonic anhydrase0101
D(1A) dopamine receptor0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0101
D(2) dopamine receptor0112
Gamma-aminobutyric acid receptor subunit alpha-194215
Gamma-aminobutyric acid receptor subunit beta-394114
Gamma-aminobutyric acid receptor subunit beta-294215
Cholinesterase0505
Carbonic anhydrase 0101
Mu-type opioid receptor0213
Fatty-acid amide hydrolase 10303
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70303
Carbonic anhydrase 90316
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase 30101
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10516
Renin0101
Carbonic anhydrase 0101
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
GABA theta subunit94114
Canalicular multispecific organic anion transporter 1011011
Carbonic anhydrase 40203
Carbonic anhydrase 150203
Acidic mammalian chitinase0101
Carbonic anhydrase 130203
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon94114
Carbonic anhydrase 0101
Carbonic anhydrase 140215
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial0215
acetylcholinesterase6006
RAR-related orphan receptor gamma120012
NFKB1 protein, partial4004
AR protein230023
signal transducer and activator of transcription 6, interleukin-4 induced1001
thyroid stimulating hormone receptor9009
regulator of G-protein signaling 47007
EWS/FLI fusion protein6007
estrogen nuclear receptor alpha260026
putative alpha-glucosidase1001
thyroid hormone receptor beta isoform 2130013
heat shock protein beta-13003
histone acetyltransferase KAT2A isoform 16006
Solute carrier family 22 member 20204
Solute carrier family 22 member 1 0305
Glutamate receptor ionotropic, NMDA 2D0314
Glutamate receptor ionotropic, NMDA 3B0314
Matrix protein 20112
Matrix protein 20123
Spike glycoprotein5005
Glutamate receptor ionotropic, NMDA 10314
Glutamate receptor ionotropic, NMDA 2A0314
Glutamate receptor ionotropic, NMDA 2B0314
Glutamate receptor ionotropic, NMDA 2C0314
Solute carrier family 22 member 10405
Glutamate receptor ionotropic, NMDA 3A0314
Multidrug and toxin extrusion protein 10101
Solute carrier family 22 member 20405
ATAD5 protein, partial8008
USP1 protein, partial120012
67.9K protein6006
peroxisome proliferator-activated receptor delta6006
chromobox protein homolog 1110011
nuclear factor erythroid 2-related factor 2 isoform 27007
Cytochrome P450 2J20505
Nicotinate phosphoribosyltransferase0101
Microtubule-associated protein tau6006
neuropeptide S receptor isoform A4004
Chain A, Ferritin light chain5005
cytochrome P450 2C19 precursor3003
lethal factor (plasmid)4004
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0003
activating transcription factor 69009
cytochrome P450 3A4 isoform 19009
Gamma-aminobutyric acid type B receptor subunit 20314
Gamma-aminobutyric acid type B receptor subunit 20202
Gamma-aminobutyric acid type B receptor subunit 10314
Gamma-aminobutyric acid type B receptor subunit 10101
Solute carrier organic anion transporter family member 1A40104
Multidrug resistance-associated protein 60001
Solute carrier organic anion transporter family member 1A50003
Endothelin receptor type B0101
Endothelin-1 receptor0203
Endothelin-1 receptor1102
Solute carrier organic anion transporter family member 1A10305
Endothelin-1 receptor0101
Canalicular multispecific organic anion transporter 10102
Solute carrier organic anion transporter family member 1B20002
Chain A, Nitrile Hydratase alpha subunit0101
Chain B, Nitrile Hydratase beta subunit0101
SMAD family member 24004
SMAD family member 34004
Lysine-specific demethylase 4E0101
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
thyroid stimulating hormone receptor6006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
Free fatty acid receptor 30022
Solute carrier family 22 member 200505
Solute carrier family 22 member 60505
Methyl-accepting chemotaxis protein NahY0011
Calpain-90101
Calpain-1 catalytic subunit0101
Cathepsin D0101
Calpain-1 catalytic subunit0202
Procathepsin L0202
Cathepsin B0202
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M30112
Muscarinic acetylcholine receptor M40112
Muscarinic acetylcholine receptor M50112
Pro-cathepsin H0101
Muscarinic acetylcholine receptor M20213
Calpain-2 catalytic subunit0101
Calpain-1 catalytic subunit0202
Vascular endothelial growth factor receptor 20101
TAR DNA-binding protein 437007
Falcipain 2B 0101
Cysteine proteinase falcipain 2a 0101
PPM1D protein3003
Acetylcholinesterase0404
L-lactate dehydrogenase A chain0101
Interferon beta9009
Cytochrome P450 1A10101
Cytochrome P450 2C11 0101
5-hydroxytryptamine receptor 1A0011
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Fatty acid-binding protein, liver0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Cytochrome P450 3A50213
Cannabinoid receptor 10304
D(1A) dopamine receptor0101
Cytochrome P450 3A70101
5-hydroxytryptamine receptor 2C0101
Caspase-10011
Cannabinoid receptor 2 0113
Mu-type opioid receptor0101
Peroxisome proliferator-activated receptor gamma0258
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
N-acylethanolamine-hydrolyzing acid amidase0101
Cytochrome P450 1B10303
Heat sensitive channel TRPV30112
Sigma intracellular receptor 20101
Transient receptor potential cation channel subfamily A member 10112
Transient receptor potential cation channel subfamily V member 10112
Transient receptor potential cation channel subfamily M member 80101
Transient receptor potential cation channel subfamily V member 40112
Transient receptor potential cation channel subfamily V member 20112
G-protein coupled receptor 550011
Diacylglycerol lipase-alpha0101
Histamine H3 receptor0202
pregnane X nuclear receptor9009
IDH15005
Vpr1001
Bile salt export pump0404
Albumin0011
Major prion protein0011
Cellular tumor antigen p53120012
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0202
UDP-glucuronosyltransferase 2B70003
Sodium channel protein type 4 subunit alpha0102
Potassium voltage-gated channel subfamily H member 20303
Sodium channel protein type 9 subunit alpha0303
Frizzled-80011
P2X purinoceptor 40101
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
muscarinic acetylcholine receptor M13003
Solute carrier family 22 member 10102
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit alpha-40202
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20202
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0426
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0102
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
pregnane X receptor3003
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
progesterone receptor8008
nonstructural protein 13003
farnesoid X nuclear receptor5005
G8008
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
serine/threonine-protein kinase mTOR isoform 11001
Solute carrier family 22 member 30101
Solute carrier family 22 member 30101
HLA class I histocompatibility antigen, B alpha chain 8008
Sex hormone-binding globulin0022
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0011
C-8 sterol isomerase0101
Nuclear receptor ROR-gamma2002
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Inositol hexakisphosphate kinase 18008
Sigma non-opioid intracellular receptor 10303
cytochrome P450 2C9, partial8008
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10303
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, 2-oxoglutarate Oxygenase5005
Chain A, Cruzipain3003
Luciferase6006
interleukin 82002
Nrf21001
15-lipoxygenase, partial3003
hypoxia-inducible factor 1 alpha subunit1001
GLS protein7007
alkaline phosphatase, intestinal0112
thioredoxin glutathione reductase4004
Smad33003
apical membrane antigen 1, AMA13003
caspase 7, apoptosis-related cysteine protease3003
PINK11001
estrogen receptor 2 (ER beta)5005
glucocerebrosidase6006
Parkin2002
bromodomain adjacent to zinc finger domain 2B4004
toll-like receptor 90101
peroxisome proliferator activated receptor gamma7007
caspase-33003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
TPA: protein transporter TIM100101
aryl hydrocarbon receptor7007
thyrotropin-releasing hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)7007
Histone H2A.x5005
lysosomal alpha-glucosidase preproprotein3003
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0112
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a4004
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
perilipin-50101
vitamin D3 receptor isoform VDRA6006
intestinal alkaline phosphatase precursor0112
perilipin-10101
potassium voltage-gated channel subfamily H member 2 isoform d4004
transcriptional regulator ERG isoform 32002
huntingtin isoform 21001
importin subunit beta-1 isoform 11001
pyruvate kinase PKM isoform a1001
DNA polymerase beta2002
nuclear factor NF-kappa-B p105 subunit isoform 11001
flap endonuclease 15005
snurportin-11001
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase iota isoform a (long)100010
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
nuclear receptor ROR-gamma isoform 16006
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
DNA polymerase kappa isoform 17007
DNA dC->dU-editing enzyme APOBEC-3G isoform 11102
alkaline phosphatase, germ cell type preproprotein0112
caspase-1 isoform alpha precursor1001
hypothetical protein SA14220101
DNA dC->dU-editing enzyme APOBEC-3F isoform a2002
Prostaglandin E synthase0101
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Lysine-specific histone demethylase 1A0101
Voltage-dependent calcium channel gamma-2 subunit4004
D-amino-acid oxidase0101
Phospholipase A20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Amyloid-beta precursor protein0405
Integrin beta-34015
Neuronal proto-oncogene tyrosine-protein kinase Src 0101
Prostaglandin G/H synthase 10202
Cholinesterase0303
Heme oxygenase 1 0101
Integrin alpha-IIb4015
Glutathione S-transferase P0101
60 kDa chaperonin0202
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Microtubule-associated protein tau0102
60 kDa heat shock protein, mitochondrial0202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0101
Tissue factor0101
Tyrosinase0101
Aminopeptidase N0101
Aminopeptidase N0101
Alpha-1B adrenergic receptor0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20202
Glycogen synthase kinase-3 beta0101
Glutamate receptor 24319
Amine oxidase [flavin-containing] A0404
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Heme oxygenase 20101
Alpha-1D adrenergic receptor0101
Amine oxidase [flavin-containing] B0505
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Proteasome subunit beta type-50101
Prostaglandin G/H synthase 20202
17-beta-hydroxysteroid dehydrogenase type 20101
Alpha-synuclein1214
Alpha-1A adrenergic receptor0101
Histamine H2 receptor3003
Glycogen synthase kinase-3 beta0202
Caspase-71001
Beta-secretase 10202
10 kDa heat shock protein, mitochondrial0202
Guanine nucleotide-binding protein G2002
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Lactoylglutathione lyase0101
Histone acetyltransferase p3000101
Serine/threonine-protein kinase PAK 10101
5-hydroxytryptamine receptor 40011
Sodium/bile acid cotransporter0112
Nuclear factor erythroid 2-related factor 20011
Thiosulfate sulfurtransferase0202
Thioredoxin reductase 1, cytoplasmic0101
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Thioredoxin reductase 30101
Sortase A0101
CREB-binding protein0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30202
Cysteine protease 0101
NACHT, LRR and PYD domains-containing protein 3 0101
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Thioredoxin reductase 2, mitochondrial0101
CDGSH iron-sulfur domain-containing protein 10404
Broad substrate specificity ATP-binding cassette transporter ABCG20405
Lymphocyte antigen 960011
Beta lactamase (plasmid)0101
Prothrombin 0101
Glandular kallikrein0101
Cell division protein FtsZ0012
Thymidine kinase, cytosolic0102
Deoxycytidine kinase0001
AAA family ATPase 0001
Sterol O-acyltransferase 10101
cytochrome P450 2D6 isoform 12002
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
Taste receptor type 2 member 460011
Cytochrome P450 2D40101
Sigma non-opioid intracellular receptor 10101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Acetylcholinesterase0101
ATP-dependent translocase ABCB10101
Amine oxidase [flavin-containing] B0202
Amine oxidase [flavin-containing] A 0202
Amine oxidase [flavin-containing] A 0101
Acetylcholinesterase0101
Liver carboxylesterase 10101
Acetylcholinesterase 0202
Acetylcholinesterase0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Cholinesterase0101
Acetylcholine receptor subunit epsilon0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Acyl-CoA:cholesterol acyltransferase 0101
Carboxylic ester hydrolase 0101
Carboxylic ester hydrolase 0202
cytochrome P450 2D65005
replicative DNA helicase0001
recombinase A0011
UDP-glucuronosyltransferase 1A90002
UDP-glucuronosyltransferase 2B170001
UDP-glucuronosyltransferase 1-60001
UDP-glucuronosyltransferase 1A1 0001
UDP-glucuronosyltransferase 1A70001
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Genome polyprotein 0112
chaperonin-containing TCP-1 beta subunit homolog1001
Fumarate hydratase1001
hypothetical protein, conserved2002
polyprotein1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eyes absent homolog 2 isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I3003
relaxin receptor 1 isoform 11001
Flavin reductase (NADPH)0011
large T antigen0202
hexokinase-4 isoform 11001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
glucokinase regulatory protein1001
Rap guanine nucleotide exchange factor 33003
Estrogen receptor0214
Aromatase0202
Polyunsaturated fatty acid lipoxygenase ALOX150101
17-beta-hydroxysteroid dehydrogenase type 10203
5-hydroxytryptamine receptor 2B0202
Estrogen receptor beta0113
Ghrelin O-acyltransferase0101
Estrogen receptor beta0001
Solute carrier organic anion transporter family member 2B1 0001
Tyrosine-protein phosphatase non-receptor type 10203
Estrogen receptor0001
Sodium/bile acid cotransporter0001
Multidrug resistance-associated protein 1 0102
Solute carrier organic anion transporter family member 1A20002
Solute carrier family 22 member 80001
Solute carrier organic anion transporter family member0001
Solute carrier organic anion transporter family member 1C10202
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1A10001
Solute carrier family 22 member 80102
Solute carrier organic anion transporter family member 1B10204
Albumin0123
Luciferin 4-monooxygenase0101
Nuclear factor NF-kappa-B p105 subunit0001
Tyrosine-protein phosphatase 10101
Ectonucleotide pyrophosphatase/phosphodiesterase family member 20202
Vesicular glutamate transporter 30101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20202
Chain A, Glutamate Receptor Subunit 20202
Chain B, Glutamate Receptor Subunit 20202
fatty acid synthase0101
Glycoprotein hormones alpha chain1001
Glutamate receptor 31316
Glutamate receptor 41316
Glutamate receptor ionotropic, kainate 10214
Glutamate receptor ionotropic, kainate 20214
Glutamate receptor 10415
Glutamate receptor 20415
Glutamate receptor 30314
Glutamate receptor 40415
Glutamate receptor ionotropic, kainate 40203
Glutamate receptor ionotropic, kainate 50203
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit alpha-10203
Gamma-aminobutyric acid receptor subunit beta-10203
Gamma-aminobutyric acid receptor subunit alpha-20203
Gamma-aminobutyric acid receptor subunit alpha-30203
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20213
Gamma-aminobutyric acid receptor subunit alpha-40203
Gamma-aminobutyric acid receptor subunit gamma-20203
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit alpha-50213
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit epsilon0202
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit theta0202
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial4004
beta-2 adrenergic receptor1001
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0022
ATP-citrate synthase 0101
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Metabotropic glutamate receptor 80011
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Glutamate receptor ionotropic, kainate 50101
Glutamate racemase0001
Prolyl 4-hydroxylase0202
Alpha-ketoglutarate-dependent dioxygenase FTO0202
Chain A, Glutamine Binding Protein0011
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10202
Serine racemase0101
Olfactory receptor 51E20022
Sodium- and chloride-dependent glycine transporter 20101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Glutamine synthetase 0101
Cytochrome P450 71B10102
Glutamine synthetase 0101
2-dehydro-3-deoxyphosphooctonate aldolase0101
Chain E, Fibrin beta chain0101
Chain A, RNA-directed RNA polymerase NS50101
WRN1001
Mcl-10101
MPI protein0101
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)0001
luciferase1001
pyruvate kinase1001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
CDK50001
serine-protein kinase ATM isoform a1001
major prion protein preproprotein Prp precursor0101
glucose-6-phosphate 1-dehydrogenase isoform b0101
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
Vif0101
Tat0101
endoribonuclease toxin MazF0011
Pyruvate kinase PKM0101
Endothelin receptor type B1001
phosphoglycerate kinase1001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
Sodium/myo-inositol cotransporter 20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
Type-1A angiotensin II receptor 0101
Type-1B angiotensin II receptor0202
Type-2 angiotensin II receptor0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
Stromelysin-10101
Matrilysin0101
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40202
D(2) dopamine receptor0101
D(4) dopamine receptor0101
D(3) dopamine receptor0101
Transporter0101
Transporter0202
Rap guanine nucleotide exchange factor 42002
alpha-galactosidase1001
cytochrome P450 2C9 precursor1001
Interstitial collagenase0101
Myeloperoxidase0101
Leukotriene A-4 hydrolase0101
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 20101
Voltage-dependent L-type calcium channel subunit beta-40101
Voltage-dependent P/Q-type calcium channel subunit alpha-1A0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent T-type calcium channel subunit alpha-1G0101
Voltage-dependent calcium channel gamma-3 subunit0101
Nuclear receptor subfamily 1 group I member 20022
Voltage-dependent T-type calcium channel subunit alpha-1H0101
Adenosine receptor A30101
Voltage-dependent L-type calcium channel subunit beta-30101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Voltage-dependent calcium channel gamma-7 subunit0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Voltage-dependent L-type calcium channel subunit beta-10101
Voltage-dependent calcium channel gamma-1 subunit0101
Voltage-dependent L-type calcium channel subunit beta-20101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Voltage-dependent R-type calcium channel subunit alpha-1E0101
Voltage-dependent calcium channel subunit alpha-2/delta-40101
Transient receptor potential cation channel subfamily A member 10011
Voltage-dependent calcium channel subunit alpha-2/delta-30101
Voltage-dependent calcium channel gamma-8 subunit0101
Bile acid receptor0101
Voltage-dependent calcium channel gamma-6 subunit0101
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Voltage-dependent T-type calcium channel subunit alpha-1I0101
Voltage-dependent calcium channel gamma-4 subunit0101
Voltage-dependent calcium channel gamma-5 subunit0101
Voltage-dependent calcium channel gamma-2 subunit0101
ras-related protein Rab-9A1001
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit beta0101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-30101
Acetylcholine receptor subunit delta0101
Taste receptor type 2 member 310011
Taste receptor type 2 member 600011
Sodium/potassium/calcium exchanger 40112
Taste receptor type 2 member 140011
Taste receptor type 2 member 130011
Taste receptor type 2 member 90011
Taste receptor type 2 member 40011
Sodium/potassium/calcium exchanger 20112
Free fatty acid receptor 20112
Free fatty acid receptor 20011
Monocarboxylate transporter 40001
Monocarboxylate transporter 20001
Monocarboxylate transporter 10001
C-terminal-binding protein 20101
Monocarboxylate transporter 20101
Solute carrier organic anion transporter family member 2A10101
CDGSH iron-sulfur domain-containing protein 10101
Free fatty acid receptor 10011
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Catechol O-methyltransferase0011
Peroxisome proliferator-activated receptor alpha0112
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Thromboxane-A synthase 0101
Peroxisome proliferator-activated receptor gamma0011
C-C chemokine receptor type 20101
Cannabinoid receptor 20011
Carnitine O-palmitoyltransferase 1, liver isoform0101
Peroxisome proliferator-activated receptor delta0213
Peroxisome proliferator-activated receptor alpha0213
ATP-binding cassette sub-family C member 80101
ATP-sensitive inward rectifier potassium channel 110101
Thrombin 0011
CDGSH iron-sulfur domain-containing protein 20101
Substance-P receptor0202
Neuromedin-K receptor0011
Substance-K receptor0112
Substance-K receptor0202
Substance-P receptor0213
Neuromedin-K receptor0112
Substance-P receptor0101
Substance-K receptor0101
Substance-K receptor0101
Growth hormone secretagogue receptor type 10011
Mas-related G-protein coupled receptor member X20011
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
Transthyretin0001
Androgen receptor0101
Thyroid hormone receptor alpha0224
Thyroid hormone receptor beta0224
Proliferating cell nuclear antigen0101
Thyroid hormone receptor beta0101
Adenosine receptor A10202
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1B30001
Urease subunit alpha0101
Urease subunit beta0101
Chain A, Arginase 10101
4-aminobutyrate aminotransferase, mitochondrial0101
4-aminobutyrate aminotransferase, mitochondrial0101
4-aminobutyrate aminotransferase, mitochondrial0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]