leflunomide and Dermal Sinus studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Research Excerpts

Excerpt	Relevance	Reference
"All 16 of the pregnancies with leflunomide exposure during pregnancy and 27 (93%) of the pregnancies with exposure prior to conception resulted in liveborn infants."	7.78	Pregnancy outcome in women exposed to leflunomide before or during pregnancy. ( Braddock, SR; Cassina, M; Chambers, CD; Jimenez, JL; Johnson, DL; Jones, KL; Luo, YJ; Mirrasoul, N; Robinson, LK; Salas, E; Xu, R, 2012)
"All 16 of the pregnancies with leflunomide exposure during pregnancy and 27 (93%) of the pregnancies with exposure prior to conception resulted in liveborn infants."	3.78	Pregnancy outcome in women exposed to leflunomide before or during pregnancy. ( Braddock, SR; Cassina, M; Chambers, CD; Jimenez, JL; Johnson, DL; Jones, KL; Luo, YJ; Mirrasoul, N; Robinson, LK; Salas, E; Xu, R, 2012)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

leflunomide and Dermal Sinus

Research Excerpts

Research

Studies (1)

Authors

Other Studies

Authors	Studies
Cassina, M	1
Johnson, DL	1
Robinson, LK	1
Braddock, SR	1
Xu, R	1
Jimenez, JL	1
Mirrasoul, N	1
Salas, E	1
Luo, YJ	1
Jones, KL	1
Chambers, CD	1