valproic acid has been researched along with Dermal Sinus in 28 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid use during pregnancy results in an absolute risk for spina bifida of 1-2%." | 4.77 | Teratogen update: valproic acid. ( Lammer, EJ; Oakley, GP; Sever, LE, 1987) |
| "Prenatal exposure to the antiepileptic drug valproic acid (VPA) has been associated with the formation of spina bifida aperta, meningocele, and meningomyelocele in the human." | 3.68 | Valproic acid-induced spina bifida: a mouse model. ( Ehlers, K; Merker, HJ; Nau, H; Stürje, H, 1992) |
| "Spina bifida occulta was demonstrated in double-stained fetal skeletons by measuring the distance between the, cartilaginous ends of each vertebral arch." | 1.31 | Valproic acid sodium-induced spina bifida occulta in the rat. ( Ceylan, S; Duru, S, 2001) |
| " It was found that both the dosage and timing of VPA administration were crucial in the development of lesions which are similar to human spina bifida aperta." | 1.27 | New animal model for the study of neural tube defects. ( McCollough, D; Michejda, M, 1987) |
| "Spina Bifida, Congenital Heart Defects, Clefts, Diaphragmatic Hernia and Trisomy 18 were more frequent than expected among babies with maternal epilepsy." | 1.27 | Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC). ( Bertollini, R; Mastroiacovo, P; Segni, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (92.86) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 1 (3.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bjerkedal, T | 1 |
| Czeizel, A | 1 |
| Goujard, J | 2 |
| Kallen, B | 1 |
| Mastroiacova, P | 1 |
| Nevin, N | 1 |
| Oakley, G | 1 |
| Robert, E | 3 |
| Castilla, E | 1 |
| Lindhout, D | 4 |
| Meinardi, H | 2 |
| Löfkvist, E | 1 |
| Mauguiere, F | 1 |
| Curran, AC | 1 |
| Frew, J | 1 |
| ten Kate, LP | 1 |
| Swagemakers, ML | 1 |
| Weemhoff, RA | 1 |
| van Eck, JH | 1 |
| Leck, I | 1 |
| Ceylan, S | 2 |
| Duru, S | 1 |
| Ehlers, K | 1 |
| Stürje, H | 1 |
| Merker, HJ | 1 |
| Nau, H | 1 |
| Guibaud, S | 1 |
| Simplot, A | 1 |
| Boisson, C | 1 |
| Pison, H | 1 |
| Haddad, J | 1 |
| Messer, J | 1 |
| Willard, D | 1 |
| Oakeshott, P | 2 |
| Hunt, GM | 1 |
| Staunton, H | 1 |
| Schmidt, D | 1 |
| Lammer, EJ | 1 |
| Sever, LE | 1 |
| Oakley, GP | 1 |
| Michejda, M | 1 |
| McCollough, D | 1 |
| Jallon, P | 1 |
| Loiseau, P | 1 |
| Bertollini, R | 1 |
| Mastroiacovo, P | 1 |
| Segni, G | 1 |
2 reviews available for valproic acid and Dermal Sinus
| Article | Year |
|---|---|
[Fetal disease caused by sodium valproate. Apropos of a case].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 1989 |
Teratogen update: valproic acid.
Topics: Abnormalities, Drug-Induced; Animals; Epidemiologic Methods; Epilepsy; Female; Humans; Infant, Newbo | 1987 |
26 other studies available for valproic acid and Dermal Sinus
| Article | Year |
|---|---|
Valproic acid and spina bifida.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregn | 1982 |
Valproic acid and spina bifida.
Topics: Adult; Anencephaly; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; S | 1983 |
Spina bifida and in-utero exposure to valproate.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Spina Bif | 1984 |
Valproate and spina bifida.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Epilepsy; Female; Humans; Middle Aged; Pregnancy; Pr | 1984 |
Spina bifida and sodium valproate.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Spina Bifida Occulta; | 1983 |
Valproic acid in pregnancy--association with spina bifida: a preliminary report.
Topics: Female; Humans; Infant, Newborn; Pregnancy; Prenatal Exposure Delayed Effects; Spina Bifida Occulta; | 1983 |
Valproate link to spina bifida.
Topics: Abnormalities, Drug-Induced; Female; Humans; Pregnancy; Risk; Spina Bifida Occulta; Valproic Acid | 1983 |
[Spina bifida caused by valproic acid?].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 1983 |
Spina bifida and anencephaly: fewer patients, more problems.
Topics: Abnormalities, Drug-Induced; Anencephaly; Female; Humans; Infant, Newborn; Neural Tube Defects; Preg | 1983 |
Valproate teratogenicity.
Topics: Female; Humans; Infant, Newborn; Pregnancy; Prenatal Exposure Delayed Effects; Spina Bifida Occulta; | 1983 |
Valproate: a new cause of birth defects--report from Italy and follow-up from France.
Topics: Abnormalities, Drug-Induced; Female; France; Humans; Infant, Newborn; Italy; Pregnancy; Spina Bifida | 1983 |
[Use of valproic acid in pregnancy: an indication for prenatal diagnosis of spina bifida].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 1984 |
Valproic acid and spina bifida: a preliminary report--France.
Topics: Epilepsy; Female; France; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Spina Bifida | 1982 |
Valproic acid sodium-induced spina bifida occulta in the rat.
Topics: Animals; Brain; Female; Gestational Age; Lumbar Vertebrae; Male; Pregnancy; Rats; Rats, Wistar; Risk | 2001 |
Valproic acid-induced spina bifida: a mouse model.
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Mice; Mice, Inbred Strains; Pr | 1992 |
[Prenatal diagnosis of 4 cases of spina bifida in mothers treated with valproate].
Topics: Adult; alpha-Fetoproteins; Amniocentesis; Female; Fetal Diseases; Humans; Pregnancy; Pregnancy Trime | 1987 |
Valproate and spina bifida.
Topics: Adult; Female; Fetal Diseases; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregnancy; Pr | 1989 |
Valproate and spina bifida.
Topics: Adult; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Spina | 1989 |
Valproate, spina bifida, and birth defect registries.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Ireland; Pregnancy; Registries; Spina | 1989 |
Valproate and spina bifida.
Topics: Female; Humans; Pregnancy; Prenatal Diagnosis; Risk Factors; Spain; Spina Bifida Occulta; Valproic A | 1989 |
In-utero exposure to valproate and neural tube defects.
Topics: Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Neural T | 1986 |
Valproate, spina bifida, and birth defect registries.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Registrie | 1988 |
New animal model for the study of neural tube defects.
Topics: Animals; Disease Models, Animal; Female; Gestational Age; Lumbar Vertebrae; Macaca mulatta; Neural T | 1987 |
Valproic acid and congenital malformations.
Topics: Anticonvulsants; Humans; Spina Bifida Occulta; Valproic Acid | 1988 |
[Neural tube malformations in children of mothers treated with sodium valproate].
Topics: Abnormalities, Drug-Induced; Female; France; Humans; Infant, Newborn; Pregnancy; Risk; Spina Bifida | 1985 |
Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC).
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1985 |