Compounds > substance p, tyr(8)-
Page last updated: 2024-11-11

substance p, tyr(8)-

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

substance P, Tyr(8)-: RN given refers to (L)-isomer; RN without isomeric designation not available 5/88 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9877153
CHEMBL ID3274942
MeSH IDM0156545

Synonyms (11)

Synonym
NCGC00167128-01
[tyr8]-substance p
55614-10-3
8-tyr-substance p
substance p, tyr(8)-
substance p, tyrosine(8)-
substance p (peptide), 8-l-tyrosine-
arg-pro-lys-pro-gln-gln-phe-tyr-gly-leu-met-nh2
CHEMBL3274942
HY-P2784
CS-0142818

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" [Tyr8]-substance P released, in vitro, the luteinizing and follicle-stimulating hormones at a very high dosage but did not release growth hormone, prolactin, or thyrotropin."( Synthesis and some biological activities of the tyrosine-8 analog of substance P.
Bowers, CY; Fisher, GH; Folkers, K; Pernow, B, 1976)		0.26
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.00050.010039.53711,122.0200AID1479
DNA polymerase kappa isoform 1Homo sapiens (human)Potency21.19230.031622.3146100.0000AID588579
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID1144906Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in FSH release at 1000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = 613 +/- 203 ng/ml)1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144905Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in LH release at 100000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = -11 +/- 27 ng/ml)1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144909Antagonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as inhibition of LH release by radioimmunoassay in presence of LH-RH1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144912Effect on prolactin release in Sprague-Dawley rat pituitary gland at 100 ug/ml by radioimmunoassay1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144904Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in LH release at 10000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = -11 +/- 27 ng/ml)1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144920Decrease in systemic arterial blood pressure in dog at 10 ng/kg, iv measured for 2 to 20 mins after drug dosage (Rvb = 140 mmHg)1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144915Retardation factor of the compound using CHCl3-MeOH-concentrated NH4OH at ratio of 60:45:20 as solvent system by thin layer chromatography1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144911Effect on growth hormone release in Sprague-Dawley rat pituitary gland at 100 ug/ml by radioimmunoassay1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144918Retardation factor of the compound using n-PrOH-1N HOAc at ratio of 2:1 as solvent system by thin layer chromatography1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144910Antagonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as inhibition of FSH release by radioimmunoassay in presence of LH-RH1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144913Effect on thyrotropin hormone release in Sprague-Dawley rat pituitary gland at 100 ug/ml by radioimmunoassay1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144908Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in FSH release at 100000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = 613 +/- 203 ng/ml)1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144916Retardation factor of the compound using EtOH-H2O at ratio of 7:3 as solvent system by thin layer chromatography1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144914Retardation factor of the compound using EtOAc-Pyr-HOAc-H2O at ratio of 5:5:1:3 as solvent system by thin layer chromatography1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144901Decrease in systemic arterial blood pressure in dog at >5 ng/kg, iv measured for 2 to 20 mins after drug dosage1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144902Agonist activity at NK1 receptor in guinea pig ileum assessed as increase in muscle tone1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144903Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in LH release at 1000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = -11 +/- 27 ng/ml)1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144907Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in FSH release at 10000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = 613 +/- 203 ng/ml)1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
AID1144917Retardation factor of the compound using n-BuOH-HOAc-EtOAc-H2O at ratio of 1:1:1:1 as solvent system by thin layer chromatography1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Synthesis and some biological activities of the tyrosine-8 analog of substance P.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (36.36)18.7374
1990's5 (45.45)18.2507
2000's2 (18.18)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.80 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.28 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
mercaptoethanol
Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.		2.3920alkanethiol;
primary alcohol		geroprotector
carbon tetrachloride
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.		2.420chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		1.9710amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
quinuclidines
Quinuclidines: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms and contains an amine group.		1.9810quinuclidines;
saturated organic heterobicyclic parent
substance p
[no description available]		3.77110peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent
l 703606
L 703606: structure given in first source		1.9810
sodium dodecyl sulfate
Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.		210organic sodium saltdetergent;
protein denaturant
chloramine-t
chloramine-T: RN given refers to unlabeled parent cpd. chloramine T : An organic sodium salt derivative of toluene-4-sulfonamide with a chloro substituent in place of an amino hydrogen.		2.3920organic sodium saltallergen;
antifouling biocide;
disinfectant
neurokinin a
Neurokinin A: A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.		1.9710
neurokinin b
Neurokinin B: A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ A with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the URINARY BLADDER and UTERUS.		1.9710polypeptide
l 760735
L 760735: an NK1 receptor antagonist		210
guanylyl imidodiphosphate
Guanylyl Imidodiphosphate: A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.. guanosine 5'-[beta,gamma-imido]triphosphate : A nucleoside triphosphate analogue that is GTP in which the oxygen atom bridging the beta- to the gamma- phosphate is replaced by a nitrogen atom A non-hydrolyzable analog of GTP, it binds tightly to G-protein in the presence of Mg(2+).		1.9810nucleoside triphosphate analogue
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		02.3620