substance P, Tyr(8)-: RN given refers to (L)-isomer; RN without isomeric designation not available 5/88 [MeSH]
| ID Source | ID |
|---|---|
| PubMed CID | 9877153 |
| CHEMBL ID | 3274942 |
| MeSH ID | M0156545 |
| Synonym |
|---|
| NCGC00167128-01 |
| [tyr8]-substance p |
| 55614-10-3 |
| 8-tyr-substance p |
| substance p, tyr(8)- |
| substance p, tyrosine(8)- |
| substance p (peptide), 8-l-tyrosine- |
| arg-pro-lys-pro-gln-gln-phe-tyr-gly-leu-met-nh2 |
| CHEMBL3274942 |
| HY-P2784 |
| CS-0142818 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0005 | AID1479 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 21.1923 | AID588579 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1144906 | Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in FSH release at 1000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = 613 +/- 203 ng/ml) | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144905 | Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in LH release at 100000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = -11 +/- 27 ng/ml) | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144909 | Antagonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as inhibition of LH release by radioimmunoassay in presence of LH-RH | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144912 | Effect on prolactin release in Sprague-Dawley rat pituitary gland at 100 ug/ml by radioimmunoassay | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144904 | Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in LH release at 10000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = -11 +/- 27 ng/ml) | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144920 | Decrease in systemic arterial blood pressure in dog at 10 ng/kg, iv measured for 2 to 20 mins after drug dosage (Rvb = 140 mmHg) | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144915 | Retardation factor of the compound using CHCl3-MeOH-concentrated NH4OH at ratio of 60:45:20 as solvent system by thin layer chromatography | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144911 | Effect on growth hormone release in Sprague-Dawley rat pituitary gland at 100 ug/ml by radioimmunoassay | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144918 | Retardation factor of the compound using n-PrOH-1N HOAc at ratio of 2:1 as solvent system by thin layer chromatography | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144910 | Antagonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as inhibition of FSH release by radioimmunoassay in presence of LH-RH | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144913 | Effect on thyrotropin hormone release in Sprague-Dawley rat pituitary gland at 100 ug/ml by radioimmunoassay | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144908 | Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in FSH release at 100000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = 613 +/- 203 ng/ml) | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144916 | Retardation factor of the compound using EtOH-H2O at ratio of 7:3 as solvent system by thin layer chromatography | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144914 | Retardation factor of the compound using EtOAc-Pyr-HOAc-H2O at ratio of 5:5:1:3 as solvent system by thin layer chromatography | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144901 | Decrease in systemic arterial blood pressure in dog at >5 ng/kg, iv measured for 2 to 20 mins after drug dosage | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144902 | Agonist activity at NK1 receptor in guinea pig ileum assessed as increase in muscle tone | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144903 | Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in LH release at 1000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = -11 +/- 27 ng/ml) | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144907 | Agonist activity at NK1 receptor in Sprague-Dawley rat pituitary gland assessed as change in FSH release at 10000 ng/ml by radioimmunoassay in presence of LH-RH (Rvb = 613 +/- 203 ng/ml) | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| AID1144917 | Retardation factor of the compound using n-BuOH-HOAc-EtOAc-H2O at ratio of 1:1:1:1 as solvent system by thin layer chromatography | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2 ISSN: 0022-2623 | Synthesis and some biological activities of the tyrosine-8 analog of substance P. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| substance p | peptide | neurokinin-1 receptor agonist; neurotransmitter; vasodilator agent | 1976 | 1976 | 48.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Muscle Contraction | 0 | 1976 | 1988 | 42.0 | high | 0 | 2 | 0 | 0 | 0 | 0 |
| Article | Year |
|---|---|
| Synthesis and some biological activities of the tyrosine-8 analog of substance P. Journal of medicinal chemistry, , Volume: 19, Issue:2 | 1976 |