Page last updated: 2024-12-07
substance p (6-11), glu(6)-
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 129892 |
| CHEMBL ID | 428532 |
| MeSH ID | M0168658 |
Synonyms (12)
| Synonym |
|---|
| substance p (6-11), glutamic acid(6)- |
| CHEMBL428532 , |
| substance p (6-11), glu(6)- |
| 4-amino-4-{1-[1-({[1-(1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-butyric acid |
| bdbm50016358 |
| (4s)-4-amino-5-[[(2s)-1-[[(2s)-1-[[2-[[(2s)-1-[[(2s)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acid |
| 6-glu-substance p (6-11) |
| l-methioninamide, l-alpha-glutamyl-l-phenylalanyl-l-phenylalanylglycyl-l-leucyl- |
| 6-glutamic acid-substance p (6-11) |
| 123067-53-8 |
| DTXSID30153856 |
| glu-phe-phe-gly-leu-met-nh2 |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " injection of either 37 nmol/kg SP, equimolar dosed SPC or corresponding diluent vehicle." | ( Naloxone blocks conditioned place preference induced by substance P and [pGlu6]-SP(6-11). Gerhardt, P; Hasenöhrl, RU; Huston, JP, 1991) | 0.28 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (9)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID187276 | Compound was evaluated for potency in SP-E system and relative potency was determined against Rat duodenumadder | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. |
| AID83667 | Compound was evaluated for potency in SP-E system and relative potency was determined against Hamster urinary bladder | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. |
| AID77492 | Compound was evaluated for K+ release in SP-P system and relative potency was determined against Guinea pig ileum | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. |
| AID234476 | potency ratio of muscular receptor/neuronal receptor | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. |
| AID77495 | Compound was evaluated for potency relative to neurokinin B against SP-N system (enteric nerves of Guinea pig ileum) | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. |
| AID175479 | Compound was evaluated for effective dose against rat parotid slices. | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. |
| AID187272 | Compound was evaluated for K+ release in SP-P system and relative potency was determined against Rat parotoid slices | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. |
| AID146289 | Compound was evaluated for effective dose against Neuronal receptor in guinea pig ileum | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. |
| AID141234 | Compound was evaluated for effective dose against Muscular receptor in guinea pig ileum | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.60
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.60) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||