Compounds > substance p (6-11), glu(6)-
Page last updated: 2024-12-07

substance p (6-11), glu(6)-

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID129892
CHEMBL ID428532
MeSH IDM0168658

Synonyms (12)

Synonym
substance p (6-11), glutamic acid(6)-
CHEMBL428532 ,
substance p (6-11), glu(6)-
4-amino-4-{1-[1-({[1-(1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-butyric acid
bdbm50016358
(4s)-4-amino-5-[[(2s)-1-[[(2s)-1-[[2-[[(2s)-1-[[(2s)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acid
6-glu-substance p (6-11)
l-methioninamide, l-alpha-glutamyl-l-phenylalanyl-l-phenylalanylglycyl-l-leucyl-
6-glutamic acid-substance p (6-11)
123067-53-8
DTXSID30153856
glu-phe-phe-gly-leu-met-nh2

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" injection of either 37 nmol/kg SP, equimolar dosed SPC or corresponding diluent vehicle."( Naloxone blocks conditioned place preference induced by substance P and [pGlu6]-SP(6-11).
Gerhardt, P; Hasenöhrl, RU; Huston, JP, 1991)		0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID187276Compound was evaluated for potency in SP-E system and relative potency was determined against Rat duodenumadder1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID83667Compound was evaluated for potency in SP-E system and relative potency was determined against Hamster urinary bladder1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID77492Compound was evaluated for K+ release in SP-P system and relative potency was determined against Guinea pig ileum1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID234476potency ratio of muscular receptor/neuronal receptor1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID77495Compound was evaluated for potency relative to neurokinin B against SP-N system (enteric nerves of Guinea pig ileum)1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID175479Compound was evaluated for effective dose against rat parotid slices.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID187272Compound was evaluated for K+ release in SP-P system and relative potency was determined against Rat parotoid slices1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID146289Compound was evaluated for effective dose against Neuronal receptor in guinea pig ileum1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
AID141234Compound was evaluated for effective dose against Muscular receptor in guinea pig ileum1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.60 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.39 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.60)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
substance p
[no description available]		2.8940peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent
naloxone
Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.. naloxone : A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.		1.9710morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
neurokinin a
Neurokinin A: A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.		1.9610
neurokinin b
Neurokinin B: A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ A with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the URINARY BLADDER and UTERUS.		1.9610polypeptide
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		02.6630