An EC 5.4.99.* (intramolecular transferase transferring other groups) inhibitor that interferes with the action of lanosterol synthase (EC 5.4.99.7).
ChEBI ID: 101086
| Member | Definition | Class |
|---|---|---|
| ro 48-8071 | An aromatic ketone that is 2-fluoro-4'-bromobenzophenone in which the hydrogen at position 4 (meta to the fluoro group) is replaced by a 6-[methyl(prop-2-en-1-yl)amino]hexyl}oxy group. An inhibitor of lanosterol synthase. | Ro 48-8071 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 13 (40.63) | 29.6817 |
| 2010's | 13 (40.63) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 32 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 12.5893 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 25.1189 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 35.4813 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 11.2202 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0065 | 1 | 1 |
| Lanosterol synthase | Homo sapiens (human) | IC50 | 0.0793 | 3 | 3 |
| Monoglyceride lipase | Rattus norvegicus (Norway rat) | IC50 | 0.0065 | 1 | 1 |
| Squalene--hopene cyclase | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | IC50 | 0.0600 | 1 | 1 |