Page last updated: 2024-08-05 15:05:03

EC 5.4.99.7 (lanosterol synthase) inhibitor

An EC 5.4.99.* (intramolecular transferase transferring other groups) inhibitor that interferes with the action of lanosterol synthase (EC 5.4.99.7).

ChEBI ID: 101086

Members (1)

MemberDefinitionClass
ro 48-8071An aromatic ketone that is 2-fluoro-4'-bromobenzophenone in which the hydrogen at position 4 (meta to the fluoro group) is replaced by a 6-[methyl(prop-2-en-1-yl)amino]hexyl}oxy group. An inhibitor of lanosterol synthase.Ro 48-8071

Research

Studies (32)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (12.50)18.2507
2000's13 (40.63)29.6817
2010's13 (40.63)24.3611
2020's2 (6.25)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other32 (100.00%)84.16%

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency12.589311
Chain A, Ferritin light chainEquus caballus (horse)Potency25.118911
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.000011
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency35.481311
phosphopantetheinyl transferaseBacillus subtilisPotency11.220211
Smad3Homo sapiens (human)Potency35.481311
TDP1 proteinHomo sapiens (human)Potency5.011922

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Fatty-acid amide hydrolase 1Rattus norvegicus (Norway rat)IC500.006511
Lanosterol synthaseHomo sapiens (human)IC500.079333
Monoglyceride lipaseRattus norvegicus (Norway rat)IC500.006511
Squalene--hopene cyclaseAlicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446IC500.060011