Compounds > kushenin
Page last updated: 2024-12-11

kushenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5318889
MeSH IDM0528387

Synonyms (7)

Synonym
kushenin
3,9-dihydroxy-8-methoxypterocarpan
LMPK12070055
8-methoxy-6a,11a-dihydro-6h-[1]benzofuro[3,2-c]chromene-3,9-diol
Q6447922
DTXSID401045291
99217-66-0

Research Excerpts

Effects

ExcerptReferenceRelevance
"Kushenin has a certain effect on inhibiting the proliferation of HCV, protecting liver cells, and anti-liver fibrosis. "( Application of kushenin on patients with chronic hepatitis C after renal transplantation.
Ding, CG; Ding, XM; Fan, P; Feng, XS; Li, Y; Song, HJ; Xue, WJ, 2008)		2.14
"Kushenin has a certain effect on inhibiting the proliferation of HCV, protecting liver cells, and anti-liver fibrosis. "( Application of kushenin on patients with chronic hepatitis C after renal transplantation.
Ding, CG; Ding, XM; Fan, P; Feng, XS; Li, Y; Song, HJ; Xue, WJ, 2008)		2.14

Compound-Compound Interactions

ExcerptReferenceRelevance
"Randomized controlled trials (RCTs) of KS combined with ETV for CHB will be identified from PubMed, EMBASE, Web of Science, The Cochrane Library, Chinese Biomedical Database, China National Knowledge Infrastructure, Chongqing VIP, Wangfang Data."( Kushenin combined with entecavir for chronic hepatitis B: A protocol for a systematic review and meta-analysis.
Jin, Y; Wang, Y; Xiao, X; Zhang, J; Zhang, Q, 2020)		2
"A high-quality synthesis of current evidence on the efficacy and safety of KS combined with ETV for CHB will be provided in this study."( Kushenin combined with entecavir for chronic hepatitis B: A protocol for a systematic review and meta-analysis.
Jin, Y; Wang, Y; Xiao, X; Zhang, J; Zhang, Q, 2020)		2
"This systematic review will aim to evaluate the efficacy and safety of KS combined with ETV for CHB."( Kushenin combined with entecavir for chronic hepatitis B: A protocol for a systematic review and meta-analysis.
Jin, Y; Wang, Y; Xiao, X; Zhang, J; Zhang, Q, 2020)		2
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (20.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
oleanolic acid
[no description available]		2.1310hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
liquiritigenin
liquiritigenin: structure given in first source; isolated from Pterocarpus marsupium. 4',7-dihydroxyflavanone : A dihydroxyflavanone in which the two hydroxy substituents are located at positions 4' and 7.. liquiritigenin : A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta.		2.13104',7-dihydroxyflavanonehormone agonist;
plant metabolite
gamma-sitosterol
clionasterol : A member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3.		2.13103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols		marine metabolite;
plant metabolite
cytellin
cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982		2.1310
entecavir
entecavir (anhydrous) : Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B.		7.25102-aminopurines;
oxopurine;
primary alcohol;
secondary alcohol		antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
guanine
[no description available]		2.25102-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Chronic Hepatitis B
[description not available]		07.2510
Hepatitis B, Chronic
INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.		02.2510
Chronic Hepatitis C
[description not available]		08.4311
Cirrhosis, Liver
[description not available]		03.4311
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.		03.4311
Hepatitis C, Chronic
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.		03.4311
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.		07.0710