senegalensin: from stem bark of Cameroonian medicinal plant Erythrina senegalensis; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
6,8-diprenylnaringenin : A trihydroxyflavanone that is (S)-naringenin substituted by prenyl groups at positions 6 and 8. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Erythrina | genus | A genus of leguminous shrubs or trees, mainly tropical, yielding useful compounds such as ALKALOIDS and PLANT LECTINS.[MeSH] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 124035 |
| CHEMBL ID | 477969 |
| CHEBI ID | 2156 |
| SCHEMBL ID | 144277 |
| MeSH ID | M0187349 |
| Synonym |
|---|
| (2s)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methylbut-2-enyl)chroman-4-one |
| senegalensien |
| 4h-1-benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methyl-2-butenyl)-, (s)- |
| C09724 |
| 6,8-diprenylnaringenin |
| 68236-11-3 |
| lonchocarpol a |
| senegalensin |
| LMPK12140276 |
| senegalensein |
| nsc721162 |
| nsc-721162 |
| (2s)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one |
| CHEMBL477969 |
| chebi:2156 , |
| 5,4'-dihydroxy-8-(gamma,gamma-dimethylallyl)-(5''-(hydroxyisopropyl)dihydrofurano(2'',3''-6.7))isoflavone |
| SCHEMBL144277 |
| (2s)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methylbut-2-en-1-yl)-2,3-dihydro-4h-1-benzopyran-4-one |
| DTXSID20218408 |
| (s)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methylbut-2-en-1-yl)chroman-4-one |
| Q27105565 |
| HY-122416 |
| CS-0085161 |
| GLXC-18378 |
| AKOS040761193 |
| FS-7456 |
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| antibacterial agent | A substance (or active part thereof) that kills or slows the growth of bacteria. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| trihydroxyflavanone | A hydroxyflavanone carrying three hydroxy substituents. |
| 4'-hydroxyflavanones | Any hydroxyflavanone having a hydroxy substituent located at position 4'. |
| (2S)-flavan-4-one | Any flavanone in which the chiral centre at position 2 has S-configuration. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID400786 | Antibacterial activity against Mycobacterium smegmatis after 24 hrs by broth microtiter susceptibility assay in absence of mouse plasma | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID401035 | Inhibition of cell wall synthesis in Bacillus megaterium Mb 410 assessed as [2,6-3H]diaminopimelic incorporation by scintillation counting | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID359968 | Antiviral activity against HIV assessed as protection against virus-induced cytopathicity by cell based XTT assay | 2001 | Journal of natural products, Apr, Volume: 64, Issue:4 | Anti-HIV prenylated flavonoids from Monotes africanus. |
| AID1537265 | Inhibition of PCSK9 mRNA level in mouse RAW264.7 cells at 20 uM by qRT-PCR assay relative to control | |||
| AID400793 | Toxicity in defibrinated sheep RBC assessed as minimum lytic concentration causing hemolysis after 2 hrs by liquid microtiter assay | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID400792 | Cytotoxicity against mouse L1210 cells after 24 hrs by trypan blue assay | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID400788 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by broth microtiter susceptibility assay in presence of mouse plasma | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID400794 | Inhibition of RNA synthesis in Bacillus megaterium Mb 410 assessed as [5,6-3H]uracil incorporation by scintillation counting | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID400787 | Antibacterial activity against Bacillus megaterium Mb 410 after 24 hrs by broth microtiter susceptibility assay in absence of mouse plasma | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID1537258 | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 20 uM by MTT assay | |||
| AID400791 | Cytotoxicity against mouse L1210 cells by MTT assay | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID401036 | Inhibition of protein synthesis in Bacillus megaterium Mb 410 assessed as L-[4,5-3H]leucine incorporation by scintillation counting | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID400789 | Antibacterial activity against vancomycin-resistant Enterococcus faecium after 24 hrs by broth microtiter susceptibility assay in presence of mouse plasma | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID400795 | Inhibition of DNA synthesis in Bacillus megaterium Mb 410 assessed as [6-3H]thymidine incorporation by scintillation counting | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID400790 | Antibacterial activity against Mycobacterium smegmatis after 24 hrs by broth microtiter susceptibility assay in presence of mouse plasma | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID400785 | Antibacterial activity against vancomycin-resistant Enterococcus faecium after 24 hrs by broth microtiter susceptibility assay in absence of mouse plasma | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| AID400784 | Antibacterial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by broth microtiter susceptibility assay in absence of mouse plasma | 1998 | Journal of natural products, May, Volume: 61, Issue:5 | Antibacterial activity of lonchocarpol A. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.74) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||