Page last updated: 2024-11-12

Licoflavone B

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

licoflavone B: Schistosomicide from Glycyrrhiza inflata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11349817
CHEMBL ID3125437
CHEBI ID186362

Synonyms (19)

Synonym
7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-6-(3-methylbut-2-enyl)chromen-4-one
licoflavone b
prenyllicoflavone a
LMPK12110029
CHEBI:186362
CHEMBL3125437 ,
91433-17-9
AKOS037515340
HY-N4184
bdbm50496210
4',7-dihydroxy-3',6-diprenylflavone
4h-1-benzopyran-4-one, 7-hydroxy-2-(4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl)-6-(3-methyl-2-buten-1-yl)-
7-hydroxy-2-(4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl)-6-(3-methyl-2-buten-1-yl)-4h-1-benzopyran-4-one
VMN9VGP9XJ ,
CS-0032377
7-hydroxy-2-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-6-(3-methylbut-2-en-1-yl)-4h-chromen-4-one
F82177
MS-26508
unii-vmn9vgp9xj
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
flavonesA member of the class of flavonoid with a 2-aryl-1-benzopyran-4-one (2-arylchromen-4-one) skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuraminidase Influenza A virus (A/Wilson-Smith/1933(H1N1))IC50 (µMol)8.90000.00000.503510.0000AID1073042; AID1073044; AID1073045
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID1073034Inhibition of Clostridium perfringens neuraminidase by fluorescence based assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
AID1453619Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 10 uM after 24 hrs by Griess reagent based assay relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1463920Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM incubated for 6 hrs by ARE-driven luciferase reporter gene assay relative to untreated control2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl
AID1453614Growth inhibition of human MCF7 cells at 10 uM after 24 hrs by MTS assay relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1453613Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1073039Antiviral activity against Influenza A virus J/8178/09 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect at 50 uM after 48 hrs2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
AID1453621Inhibition of LPS-induced NF-kappaB transcription (unknown origin) expressed in human SW480 cells at 10 uM by luciferase reporter gene assay2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1073035Induction of fluorescence quenching at 100 uM relative to 4-methylumbelliferone2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
AID1073043Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by chemiluminescence based assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
AID1073044Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemiluminescence based assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
AID1453625Inhibition of mushroom tyrosinase at 10 uM using L-tyrosine as substrate incubated for 15 mins followed by substrate addition relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1073036Induction of fluorescence at 100 uM relative to 4-methylumbelliferone2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
AID1073032Selectivity ratio of IC50 for Clostridium perfringens neuraminidase to IC50 for Influenza A virus neuraminidase2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
AID1453616Growth inhibition of human HepG2 cells at 10 uM after 24 hrs by MTS assay relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1073038Antiviral activity against Influenza A virus (A/Hong Kong/1/1968(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect at 50 uM after 48 hrs2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
AID1453609Growth inhibition of human HEK293T cells at 10 uM after 24 hrs by MTS assay relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1073037Cytotoxicity against MDCK cells after 72 hrs2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
AID1453623Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate at 10 uM after 30 mins relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1453610Growth inhibition of human LO2 cells at 10 uM after 24 hrs by MTS assay relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1453612Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 24 hrs by MTS assay2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1453615Growth inhibition of human SW480 cells at 10 uM after 24 hrs by MTS assay relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1073042Inhibition of Influenza A virus (A/Hong Kong/1/1968(H3N2)) neuraminidase by chemiluminescence based assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
AID1073045Inhibition of Influenza A virus J/8178/09 neuraminidase by chemiluminescence based assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
AID1073033Inhibition of Clostridium perfringens neuraminidase by chemiluminescence based assay2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Computer-guided approach to access the anti-influenza activity of licorice constituents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]