Page last updated: 2024-12-07

butin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

butin: isolated from seeds of Butea monosperma; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

butin : A trihydroxyflavanone in which the three hydroxy substituents are located at positions 3', 4' and 7. It is found in Acacia mearnsii, Vernonia anthelmintica and Dalbergia odorifera and has a protective affect against oxidative stress-induced mitochondrial dysfunction. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
ButeagenusA plant genus of the family FABACEAE that contains butrin and isobutrin.[MeSH]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

Cross-References

ID SourceID
PubMed CID3496769
CHEMBL ID3401430
CHEBI ID183341
SCHEMBL ID5504140
MeSH IDM0146405

Synonyms (20)

Synonym
MEGXP0_000004
ACON1_000269
NCGC00180724-01
butin
BRD-A75085792-001-01-8
2-(3,4-dihydroxyphenyl)-7-hydroxy-3,4-dihydro-2h-1-benzopyran-4-one
CHEBI:183341
2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydrochromen-4-one
3',4',7-trihydroxyflavanone
SCHEMBL5504140
21913-99-5
CHEMBL3401430
HY-N6020B
CS-0106898
2-(3,4-dihydroxyphenyl)-7-hydroxychroman-4-one
MS-23848
B2703-142961
2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-4h-1-benzopyran-4-one
DTXSID301162721
AKOS040732682
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
flavanonesMembers of the class of flavans with a 3,4-dihydro-2-aryl-2H-1-benzopyran-4-one skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID1193617Induction of melanogenesis in C57BL/6 depigmentation mouse assessed as increase in MITF protein expression at 1.6 to 4.8 mg/kg, ip for 2 weeks measured on day 12 by H&E staining-based histomorphology2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Synthesis and melanogenesis evaluation of 3',4',7-trihydroxyflavanone derivatives and characterization of flavanone-BODIPY.
AID1193615Induction of melanogenesis in C57BL/6 depigmentation mouse assessed as increase in TRP-1 protein expression at 1.6 to 4.8 mg/kg, ip for 2 weeks measured on day 12 by H&E staining-based histomorphology2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Synthesis and melanogenesis evaluation of 3',4',7-trihydroxyflavanone derivatives and characterization of flavanone-BODIPY.
AID1193618Induction of melanogenesis in mouse B16F10 cells at 0.01 to 10 uM after 48 hrs by fluorescence microscopy relative to control2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Synthesis and melanogenesis evaluation of 3',4',7-trihydroxyflavanone derivatives and characterization of flavanone-BODIPY.
AID1193613Induction of melanogenesis in C57BL/6 depigmentation mouse assessed as increase in melanin content of hair follicle on depigmented skin at 1.6 to 4.8 mg/kg, ip for 2 weeks by H&E stainig-based histomorphology2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Synthesis and melanogenesis evaluation of 3',4',7-trihydroxyflavanone derivatives and characterization of flavanone-BODIPY.
AID1193614Induction of melanogenesis in C57BL/6 depigmentation mouse assessed as increase in tyrosinase protein expression at 1.6 to 4.8 mg/kg, ip for 2 weeks measured on day 12 by H&E staining-based histomorphology2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Synthesis and melanogenesis evaluation of 3',4',7-trihydroxyflavanone derivatives and characterization of flavanone-BODIPY.
AID1193616Induction of melanogenesis in C57BL/6 depigmentation mouse assessed as increase in TRP-2 protein expression at 1.6 to 4.8 mg/kg, ip for 2 weeks measured on day 12 by H&E staining-based histomorphology2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Synthesis and melanogenesis evaluation of 3',4',7-trihydroxyflavanone derivatives and characterization of flavanone-BODIPY.
AID1193612Induction of melanin synthesis in mouse B16F10 cells after 48 hrs by fluorescence microscopy relative to control2015Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7
Synthesis and melanogenesis evaluation of 3',4',7-trihydroxyflavanone derivatives and characterization of flavanone-BODIPY.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (19.05)18.7374
1990's0 (0.00)18.2507
2000's4 (19.05)29.6817
2010's11 (52.38)24.3611
2020's2 (9.52)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]