Page last updated: 2024-11-12
licochalcone d
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
licochalcone D: isolated from Glycyrrhiza inflata; inhibits phosphorylation of NF-kappaB p65 in LPS signaling pathway [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
Flora | Rank | Flora Definition | Family | Family Definition |
---|---|---|---|---|
Glycyrrhiza | genus | A genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivative, CARBENOXOLONE.[MeSH] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
Cross-References
ID Source | ID |
---|---|
PubMed CID | 10473311 |
CHEMBL ID | 1644932 |
MeSH ID | M0536803 |
Synonyms (23)
Synonym |
---|
LMPK12120425 |
licochalcone d |
CHEMBL1644932 |
licochalcone d [mi] |
(2e)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-2-propen-1-one |
2-propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-, (e)- |
144506-15-0 |
unii-3p0sh94v09 |
3p0sh94v09 , |
2-propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-, (2e)- |
S6899 |
DTXSID00162738 |
bdbm50483309 |
AKOS037515337 |
HY-N4187 |
CS-0032380 |
Q27257833 |
(e)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one |
(e)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)prop-2-en-1-one |
MS-25526 |
2-propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methyl-2-butenyl)p henyl]-, (e)- |
XL173147 |
E88806 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (13)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1061196 | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 2 uM after 24 hrs by MTS assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis of licochalcone analogues with increased anti-inflammatory activity. |
AID1061200 | Antiinflammatory activity in RBL2H3 cells assessed as inhibition of degranulation | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis of licochalcone analogues with increased anti-inflammatory activity. |
AID549515 | Inhibition of Influenza A H1N1 virus neuraminidase activity after 2 hrs by spectrofluorometry | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata. |
AID549518 | Inhibition of Influenza A H9N2 virus neuraminidase activity after 2 hrs by spectrofluorometry | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata. |
AID1463921 | Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 2.5 to 20 uM incubated for 6 hrs by ARE-driven luciferase reporter gene assay | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20 | Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl |
AID549519 | Noncompetitive inhibition of Influenza A H1N1 virus neuraminidase activity by Lineweaver-Burk plot analysis | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata. |
AID1061199 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production at 2 uM after 18 hrs by Griess assay relative to control | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis of licochalcone analogues with increased anti-inflammatory activity. |
AID1463920 | Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM incubated for 6 hrs by ARE-driven luciferase reporter gene assay relative to untreated control | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20 | Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl |
AID1061198 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production at 20 uM after 18 hrs by Griess assay relative to control | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis of licochalcone analogues with increased anti-inflammatory activity. |
AID1463923 | Cytotoxicity in human HepG2 cells expressing Nrf2/ARE-driven luciferase at 20 to 40 uM incubated for 6 hrs | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20 | Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl |
AID549521 | Inhibition of Clostridium perfringens neuraminidase | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1 | Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata. |
AID1061197 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 18 hrs by Griess assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis of licochalcone analogues with increased anti-inflammatory activity. |
AID1061195 | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 20 uM after 24 hrs by MTS assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1 | Synthesis of licochalcone analogues with increased anti-inflammatory activity. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (11)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (9.09) | 29.6817 |
2010's | 7 (63.64) | 24.3611 |
2020's | 3 (27.27) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 19.27
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (19.27) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 11 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |