Compounds > vestitone

Page last updated: 2024-11-08

vestitone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID Source	ID
PubMed CID	439310
CHEMBL ID	4216686
CHEBI ID	16786
SCHEMBL ID	213646
MeSH ID	M0235567

Synonyms (14)

Synonym
7,2'-dihydroxy-4'-methoxyisoflavanone
2,3-dihydro-7-hydroxy-3-(2-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one
(3r)-7-hydroxy-3-(2-hydroxy-4-methoxyphenyl)-2,3-dihydro-4h-chromen-4-one
(3r)-vestitone
CHEBI:16786
vestitone ,
C00786
158112-50-6
(-)-vestitone
(3r)-7-hydroxy-3-(2-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
SCHEMBL213646
DTXSID60331403
Q23055339
CHEMBL4216686

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

Role	Description
antibacterial agent	A substance (or active part thereof) that kills or slows the growth of bacteria.
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

Class	Description
hydroxyisoflavanone	Any member of the class of isoflavanones with at least one hydroxy substituent.
methoxyisoflavanone	Members of the class of isoflavanones with at least one methoxy substituent.
(3R)-2'-hydroxyisoflavanones	Any member of the class of hydroxyisoflavans that has a hydroxy substituent located at position 2 and 3R-stereochemistry.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (4)

Pathway	Proteins	Compounds
superpathway of pterocarpan biosynthesis (via formononetin)	0	31
(-)-medicarpin biosynthesis	0	10
superpathway of formononetin derivative biosynthesis	0	31
(-)-medicarpin biosynthesis	2	10
superpathway of pterocarpan biosynthesis (via formononetin)	3	34
superpathway of formononetin derivative biosynthesis	2	34
Medicarpin biosynthesis	0	12

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID1374882	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production	2018	Bioorganic & medicinal chemistry letters, 04-01, Volume: 28, Issue:6	Anti-inflammatory isoflavones and isoflavanones from the roots of Pongamia pinnata (L.) Pierre.
AID1374883	Cytotoxicity against mouse BV2 cells at 50 uM by MTT assay	2018	Bioorganic & medicinal chemistry letters, 04-01, Volume: 28, Issue:6	Anti-inflammatory isoflavones and isoflavanones from the roots of Pongamia pinnata (L.) Pierre.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
liquiritigenin liquiritigenin: structure given in first source; isolated from Pterocarpus marsupium. 4',7-dihydroxyflavanone : A dihydroxyflavanone in which the two hydroxy substituents are located at positions 4' and 7.. liquiritigenin : A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta.	2.02	1	0	4',7-dihydroxyflavanone	hormone agonist; plant metabolite
medicarpin (-)-medicarpin : The (-)-enantiomer of medicarpin.	2.4	2	0	medicarpin	plant metabolite
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	2	1	0	cyclodextrin
hydroxypropyl-gamma-cyclodextrin [no description available]	2	1	0
butin butin: isolated from seeds of Butea monosperma; structure given in first source. butin : A trihydroxyflavanone in which the three hydroxy substituents are located at positions 3', 4' and 7. It is found in Acacia mearnsii, Vernonia anthelmintica and Dalbergia odorifera and has a protective affect against oxidative stress-induced mitochondrial dysfunction.	2.02	1	0	flavanones
formononetin [no description available]	2.17	1	0	4'-methoxyisoflavones; 7-hydroxyisoflavones	phytoestrogen; plant metabolite
genistein [no description available]	2.17	1	0	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
daidzein [no description available]	2.17	1	0	7-hydroxyisoflavones	antineoplastic agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; phytoestrogen; plant metabolite
4'-methoxy-3',5,7-trihydroxyisoflavone 4'-methoxy-3',5,7-trihydroxyisoflavone: structure in first source. pratensein : A member of the class of 7-hydroxyisoflavones in which isoflavone is substituted by hydroxy groups at the 5, 7, and 3' positions, and by a methoxy group at the 4' position.	2.17	1	0	4'-methoxyisoflavones; 7-hydroxyisoflavones
7,4'-dihydroxy-3'-methoxyisoflavone 7,4'-dihydroxy-3'-methoxyisoflavone : A member of the class of 7-hydroxyisoflavones that is 7,4'-dihydroxyisoflavone substituted by a methoxy group at position 3'. It is isolated from the heart woods of Maackia amurensis subsp buergeri and Dalbergia louveli and exhibits antiplasmodial ativity.	2.17	1	0	7-hydroxyisoflavones; methoxyisoflavone	antiplasmodial drug; metabolite
3'-o-methylorobol 3'-O-methylorobol: isolated from Eclipta prostrata; has stimulatory effect on mouse osteoblast differentiation; structure in first source. 3'-O-methylorobol : A hydroxyisoflavone that is orobol in which the hydroxy group at position 3' has been replaced by a methoxy group. It has been isolated from Crotalaria lachnophora.	2.17	1	0	hydroxyisoflavone; methoxyisoflavone	plant metabolite