Page last updated: 2024-12-10

isoschaftoside

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

isoschaftoside: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

isoschaftoside : A C-glycosyl compound that is apigenin substituted at positions 6 and 8 by alpha-L-arabinopyranosyl and beta-D-glucosyl residues respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID3084995
CHEMBL ID2437365
CHEBI ID75589
SCHEMBL ID5082977
MeSH IDM0504290

Synonyms (32)

Synonym
52012-29-0
h27x8715v3 ,
4h-1-benzopyran-4-one, 6-alpha-l-arabinopyranosyl-8-beta-d-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-
unii-h27x8715v3
isoschaftoside
5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-6-[(2s,3r,4s,5s)-3,4,5-trihydroxyoxan-2-yl]chromen-4-one
CHEMBL2437365
CHEBI:75589 ,
5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl]-6-[(2s,3r,4s,5s)-3,4,5-trihydroxytetrahydro-2h-pyran-2-yl]-4h-chromen-4-one
6-c-alpha-l-arabinopyranosyl-8-c-beta-d-glucosylapigenin
apigenin 6-c-arabinoside 8-c-glucoside
SCHEMBL5082977
apigenin-6-arabinoside-8-glucoside
AC-35000
5,7,4'-trihydroxy-6-c-arabinoside-8-c-glucoside flavone
6-c-.alpha.-l-arabinosyl-8-c-.beta.-d-glucosylapigenin
apigenin 6-c-.alpha.-l-arabinoside 8-c-.beta.-d-glucoside
isoshaftoside
2-(4-hydroxyphenyl)-5,7-dihydroxy-6-(alpha-l-arabinopyranosyl)-8-(beta-d-glucopyranosyl)-4h-1-benzopyran-4-one
j376.232g ,
5,7-dihydroxy-2-(4-hydroxyphenyl)-8-((2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)-6-((2s,3r,4s,5s)-3,4,5-trihydroxytetrahydro-2h-pyran-2-yl)-4h-chromen-4-one
apigenin 6-c-.alpha.-l-arabinopyranoside-8-c-.beta.-d-glucopyranoside
76491-12-8
6-(.alpha.-l-arabinopyranosyl)-8-(.beta.-d-glucopyranosyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one
FT-0698519
AKOS030573652
Q27145412
mfcd00210518
HY-N1458
CS-0016904
MS-30225
DTXSID301317293

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
"The novel integrated double peak pharmacokinetic approach to studying the holistic pharmacokinetic properties of traditional Chinese medicine has been successfully developed and validated using AM as a model drug."( Integrated pharmacokinetics and biodistribution of multiple flavonoid C-glycosides components in rat after oral administration of Abrus mollis extract and correlations with bio-effects.
Gu, N; Huo, M; Jiang, Z; Wang, H; Xiong, F; Yan, C; Zheng, C, 2015
)
0.42

Compound-Compound Interactions

ExcerptReferenceRelevance
") Merr has been established, based on analysis of high-performance liquid chromatography fingerprint combined with the similarity analysis (SA), hierarchical cluster analysis (HCA), principal component analysis (PCA), discriminant analysis (DA) and the quantitative analysis multi-components by single marker (QAMS) method."( Quantitative and Chemical Fingerprint Analysis of Desmodium styracifolium by High-Performance Liquid Chromatography Combined with Chemometrics.
Chen, L; Cheng, X; Tang, X; Yang, Q, 2020
)
0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
C-glycosyl compoundA glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a carbon atom, thus creating a C-C bond.
trihydroxyflavoneAny hydroxyflavone carrying three hydroxy groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID775570Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate at 100 uM2013Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's7 (70.00)24.3611
2020's2 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.91

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.91 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.91)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]