| Assay ID | Title | Year | Journal | Article |
|---|
| AID1799488 | Inhibition Assay from Article 10.1016/j.chembiol.2003.11.012: \\Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase.\\ | 2003 | Chemistry & biology, Dec, Volume: 10, Issue:12
| Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase. |
| AID1799167 | Thymidylate Synthase (TS) Assay from Article 10.1021/jm900490a: \\Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reduct | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. |
| AID1797770 | Dihydrofolate Reductase (DHFR) Assay from Article 10.1021/jm058234m: \\Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimid | 2005 | Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23
| Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofol |
| AID1798000 | Thymidylate Synthase (TS) Assay from Article 10.1021/jm701052u: \\Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reduct | 2008 | Journal of medicinal chemistry, Jan-10, Volume: 51, Issue:1
| Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID1797761 | Thymidylate Synthase (TS) Assay from Article 10.1021/jm051187d: \\Antibacterial agent discovery using thymidylate synthase biolibrary screening.\\ | 2006 | Journal of medicinal chemistry, Oct-05, Volume: 49, Issue:20
| Antibacterial agent discovery using thymidylate synthase biolibrary screening. |
| AID613093 | Inhibition of human TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID282573 | Inhibition of Lactobacillus casei DHFR | 2004 | Journal of medicinal chemistry, Dec-30, Volume: 47, Issue:27
| Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
| AID98199 | Growth inhibition of murine tumor L1210 cell line | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID312256 | Inhibition of human recombinant DHFR | 2008 | Journal of medicinal chemistry, Jan-10, Volume: 51, Issue:1
| Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID99331 | Relative resistance ratio evaluated for murine tumor L1210:1565 cells with 10% fetal calf serum as supplement | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID312257 | Inhibition of Escherichia coli DHFR | 2008 | Journal of medicinal chemistry, Jan-10, Volume: 51, Issue:1
| Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID211785 | Compound was evaluated for the inhibition at a given concentration against Lactobacillus casei TS | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase. |
| AID99330 | Inhibition of cell growth in culture against murine tumor L1210:1565 cell lines | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID260046 | Inhibition of DHFR from Escherichia coli | 2006 | Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3
| Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1). |
| AID58146 | Inhibitory activity against Dihydrofolate reductase in rat liver | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. |
| AID477806 | Inhibition of thymidylate synthase | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4
| 3D-QSAR studies on quinazoline antifolate thymidylate synthase inhibitors by CoMFA and CoMSIA models. |
| AID282572 | Inhibition of Escherichia coli DHFR | 2004 | Journal of medicinal chemistry, Dec-30, Volume: 47, Issue:27
| Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
| AID422638 | Ratio of IC50 for human recombinant dihydrofolate reductase to IC50 for Toxoplasma gondii dihydrofolate reductase | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. |
| AID211818 | Compound was tested for inhibition of Thymidylate Synthase in Lactobacillus casei, | 1986 | Journal of medicinal chemistry, Apr, Volume: 29, Issue:4
| Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase. |
| AID21135 | Solubility in 0.92 M aqueous NaH2PO4 buffer at pH 7.0 and 25 degree C | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. |
| AID212486 | Concentration required for in vitro inhibition of thymidylate synthase | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. |
| AID217933 | Inhibition of human derived cell line W1-L2 cell proliferation | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents. |
| AID100496 | Concentration required to inhibit 50% growth of L1210 mouse leukemia cells was determined | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID312253 | Inhibition of human thymidylate synthase | 2008 | Journal of medicinal chemistry, Jan-10, Volume: 51, Issue:1
| Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID282388 | Inhibition of human DHFR | 2004 | Journal of medicinal chemistry, Dec-30, Volume: 47, Issue:27
| Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents. |
| AID212157 | Compound was evaluated as inhibitor of human thymidylate synthase | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
| Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and |
| AID613095 | Inhibition of Toxoplasma gondii TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID212677 | Inhibitory concentration against isolated rat thymidylate synthase | 2000 | Journal of medicinal chemistry, Oct-19, Volume: 43, Issue:21
| Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. |
| AID272990 | Specificity Index, Ki for human thymidylate synthase/Ki for Lactobacillus casei thymidylate synthase | 2006 | Journal of medicinal chemistry, Oct-05, Volume: 49, Issue:20
| Antibacterial agent discovery using thymidylate synthase biolibrary screening. |
| AID422633 | Inhibition of Escherichia coli thymidylate synthase | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. |
| AID101072 | Concentration required to inhibit 50 percent growth of L1210 mouse leukemia cells | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. |
| AID99336 | Relative resistance ratio evaluated for murine tumor L1210:RD1694 cells with 10% horse serum as supplement | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID312255 | Inhibition of Toxoplasma gondii thymidylate synthase | 2008 | Journal of medicinal chemistry, Jan-10, Volume: 51, Issue:1
| Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID260039 | Inhibition of recombinant human DHFR | 2006 | Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3
| Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1). |
| AID422635 | Inhibition of human recombinant dihydrofolate reductase | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. |
| AID282575 | Inhibition of Escherichia coli thymidylate synthase | 2004 | Journal of medicinal chemistry, Dec-30, Volume: 47, Issue:27
| Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
| AID96477 | Inhibition concentration against L1210 cells | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives. |
| AID613097 | Inhibition of Escherichia coli DHFR by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID312259 | Selectivity ratio of IC50 for Toxoplasma gondii DHFR over IC50 for human recombinant DHFR | 2008 | Journal of medicinal chemistry, Jan-10, Volume: 51, Issue:1
| Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID211799 | Inhibitory concentration against isolated Lactobacillus casei Thymidylate synthase | 2000 | Journal of medicinal chemistry, Oct-19, Volume: 43, Issue:21
| Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. |
| AID211441 | Inhibitory activity against Escherichia coli thymidylate synthase | 2001 | Journal of medicinal chemistry, Jun-07, Volume: 44, Issue:12
| Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines. |
| AID100497 | In vitro inhibition of L1210 mouse leukemia cell growth in culture | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents. |
| AID212654 | Binding affinity against thymidylate synthase from murine leukemia L1210 | 1987 | Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
| Folate analogues as inhibitors of thymidylate synthase. |
| AID282574 | Inhibition of human recombinant thymidylate synthase | 2004 | Journal of medicinal chemistry, Dec-30, Volume: 47, Issue:27
| Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
| AID93926 | Concentration required to inhibit 50% growth of L1210 of R7A mutant mouse leukemia cell line was determined | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID212643 | Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cells | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID212128 | Inhibitory activity against recombinant Pneumocystis carinii TS | 2001 | Journal of medicinal chemistry, Jun-07, Volume: 44, Issue:12
| Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines. |
| AID100494 | The inhibitory activity was determined on L1210 mouse leukemia cell in presence of thymidine | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID212493 | In vitro inhibitory activity against thymidylate synthase (TS) from L1210 mouse leukemia cells | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents. |
| AID97899 | The compound was tested for inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cells | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID272988 | Inhibition of human thymidylate synthase | 2006 | Journal of medicinal chemistry, Oct-05, Volume: 49, Issue:20
| Antibacterial agent discovery using thymidylate synthase biolibrary screening. |
| AID212159 | Compound was evaluated for the inhibition at a given concentration against recombinant human TS | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase. |
| AID99335 | Tested for inhibition of cell growth in culture against murine tumor L1210:RD1694 cell lines | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID272991 | Specificity Index, Ki for human thymidylate synthase/Ki for Escherichia coli thymidylate synthase | 2006 | Journal of medicinal chemistry, Oct-05, Volume: 49, Issue:20
| Antibacterial agent discovery using thymidylate synthase biolibrary screening. |
| AID212653 | Binding affinity against Thymidylate synthase was measured in vitro | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. |
| AID212301 | Inhibitory concentration against isolated Thymidylate synthase | 2000 | Journal of medicinal chemistry, Oct-19, Volume: 43, Issue:21
| Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. |
| AID1607764 | Inhibition of HAT (unknown origin) | 2019 | European journal of medicinal chemistry, Sep-15, Volume: 178 | Histone acetyltransferase inhibitors: An overview in synthesis, structure-activity relationship and molecular mechanism. |
| AID212457 | Inhibitory constant of thymidylate synthase was determined in human AML cells | 1987 | Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
| Folate analogues as inhibitors of thymidylate synthase. |
| AID211446 | Inhibitory concentration against isolated Escherichia coli Thymidylate synthase | 2000 | Journal of medicinal chemistry, Oct-19, Volume: 43, Issue:21
| Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. |
| AID93927 | Compound was tested for relative resistance to L1210 (1565) cell line | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID613098 | Inhibition of Toxoplasma gondii DHFR by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID93925 | Concentration required to inhibit 50% growth of L1210 /1565 mutant mouse leukemia cell line was determined | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID212156 | Ability to inhibit thymidylate synthase derived from human leukemia K562 cells | 1987 | Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
| Folate analogues as inhibitors of thymidylate synthase. |
| AID613094 | Inhibition of Escherichia coli TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID422637 | Inhibition of Toxoplasma gondii dihydrofolate reductase | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. |
| AID282389 | Inhibition of Escherichia coli DHFR | 2004 | Journal of medicinal chemistry, Dec-30, Volume: 47, Issue:27
| Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents. |
| AID212153 | Inhibitory activity against thymidylate synthase (TS) | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives. |
| AID422632 | Inhibition of human thymidylate synthase | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. |
| AID272986 | Inhibition of Escherichia coli thymidylate synthase | 2006 | Journal of medicinal chemistry, Oct-05, Volume: 49, Issue:20
| Antibacterial agent discovery using thymidylate synthase biolibrary screening. |
| AID211439 | Compound was evaluated as inhibitor of Escherichia coli thymidylate synthase | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
| Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and |
| AID422636 | Inhibition of Escherichia coli dihydrofolate reductase | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. |
| AID260014 | Inhibition of TS from Escherichia coli | 2006 | Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3
| Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1). |
| AID282387 | Inhibition of Escherichia coli thymidylate synthase | 2004 | Journal of medicinal chemistry, Dec-30, Volume: 47, Issue:27
| Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents. |
| AID212297 | Inhibitory activity against human thymidylate synthase | 2001 | Journal of medicinal chemistry, Jun-07, Volume: 44, Issue:12
| Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines. |
| AID312254 | Inhibition of Escherichia coli thymidylate synthase | 2008 | Journal of medicinal chemistry, Jan-10, Volume: 51, Issue:1
| Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID282386 | Inhibition of human thymidylate synthase | 2004 | Journal of medicinal chemistry, Dec-30, Volume: 47, Issue:27
| Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents. |
| AID211645 | Compound was evaluated as inhibitor of Lactobacillus casei thymidylate synthase | 2003 | Journal of medicinal chemistry, Feb-13, Volume: 46, Issue:4
| Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and |
| AID212327 | Binding affinity against human enzyme thymidylate synthase derived from either HeLa or KB cells | 1987 | Journal of medicinal chemistry, Apr, Volume: 30, Issue:4
| Folate analogues as inhibitors of thymidylate synthase. |
| AID312258 | Inhibition of Toxoplasma gondii DHFR | 2008 | Journal of medicinal chemistry, Jan-10, Volume: 51, Issue:1
| Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID422634 | Inhibition of Toxoplasma gondii thymidylate synthase | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. |
| AID613096 | Inhibition of human DHFR by spectrophotometry | 2011 | Bioorganic & medicinal chemistry, Jun-01, Volume: 19, Issue:11
| Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
| AID93928 | Compound was tested for relative resistance to L1210 (R7A) cell line | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID272985 | Inhibition of Lactobacillus casei thymidylate synthase | 2006 | Journal of medicinal chemistry, Oct-05, Volume: 49, Issue:20
| Antibacterial agent discovery using thymidylate synthase biolibrary screening. |
| AID282571 | Inhibition of human recombinant DHFR | 2004 | Journal of medicinal chemistry, Dec-30, Volume: 47, Issue:27
| Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
| AID260013 | Inhibition of recombinant human TS | 2006 | Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3
| Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1). |
| AID282576 | Inhibition of Lactobacillus casei thymidylate synthase | 2004 | Journal of medicinal chemistry, Dec-30, Volume: 47, Issue:27
| Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. |
| AID212485 | Concentration required to inhibit 50% activity of Thymidylate synthase was determined | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID1159588 | Biochemical screen of P. falciparum CDPK4 | 2016 | PloS one, , Volume: 11, Issue:3
| Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. |
| AID1159587 | Biochemical screen of P. falciparum PK7 | 2016 | PloS one, , Volume: 11, Issue:3
| Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. |
| AID1159585 | Biochemical screen of P. falciparum CDPK1 | 2016 | PloS one, , Volume: 11, Issue:3
| Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. |
| AID1159586 | Biochemical screen of P. falciparum PK6 | 2016 | PloS one, , Volume: 11, Issue:3
| Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. |
| AID1159589 | Biochemical screen of P. falciparum MAPK2 | 2016 | PloS one, , Volume: 11, Issue:3
| Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |