Compounds > flucofuron
Page last updated: 2024-12-06

flucofuron

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

Flucofuron is a synthetic insecticide that belongs to the class of pyrethroids. It is a potent inhibitor of sodium channels in insects, leading to paralysis and death. Flucofuron is effective against a wide range of insects, including pests that are resistant to other insecticides. Its synthesis involves a multi-step process that starts with a pyrethroid precursor molecule. The development of flucofuron was driven by the need for new and effective insecticides to control insect pests in agriculture and public health. Research on flucofuron focuses on understanding its mechanism of action, its environmental fate, and its potential for resistance development in insect populations. It is also studied to assess its safety for humans and other non-target organisms. Flucofuron's importance lies in its contribution to pest control, which helps to protect crops and human health from the negative impacts of insect infestation.'

flucofuron: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

flucofuron : A member of the class of phenylureas that is urea in which each nitrogen is substituted by a 4-chloro-3-(trifluoromethyl)phenyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID67788
CHEMBL ID530543
CHEBI ID59242
SCHEMBL ID118026
MeSH IDM0267552

Synonyms (31)

Synonym
flucofuron
1,3-bis(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)urea
n,n'-bis[4-chloro-3-(trifluoromethyl)phenyl]urea
chebi:59242 ,
1,3-bis[4-chloro-3-(trifluoromethyl)phenyl]urea
mitin n
CHEMBL530543
370-50-3
TCMDC-137559 ,
u3v3s70655 ,
unii-u3v3s70655
urea, n,n'-bis(4-chloro-3-(trifluoromethyl)phenyl)-
einecs 206-728-7
flucofuron [iso]
n,n'-bis(4-chloro-3-trifluoromethyl)phenyl urea
EPITOPE ID:131790
SCHEMBL118026
1,3-bis(4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)urea
n,n'-bis(4-chloro-3-(trifluoromethyl)phenyl)urea
sorafenib impurity 8
urea, n,n'-bis[4-chloro-3-(trifluoromethyl)phenyl]-; n,n'-bis[4-chloro-3-(trifluoromethyl)phenyl]urea; 4,4'-dichloro-3,3'-bis(trifluoromethyl)carbanilide; flucofenuron; flucofuron; mitin n
1,3-bis(4-chloro-3-(trifluoromethyl)phenyl)urea
DTXSID50891521
bis(4-chloro-3-(trifluoromethyl)phenyl)urea
Q27126562
BS-45393
A899638
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
sorafenibimpurity8
CS-0009766
Z90731166
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
epitopeThe biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
organofluorine pesticide
organochlorine pesticideAny organochlorine compound that has been used as a pesticide.
monochlorobenzenesAny member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine.
(trifluoromethyl)benzenesAn organofluorine compound that is (trifluoromethyl)benzene and derivatives arising from substitution of one or more of the phenyl hydrogens.
phenylureasAny member of the class of ureas in which at least one of the nitrogens of the urea moiety is substituted by a phenyl or substituted phenyl group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID1281537Antischistosomal activity against adult stage of Schistosoma japonicum after 72 hrs by microscopy2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Antischistosomal activity of N,N'-arylurea analogs against Schistosoma japonicum.
AID1885647Anti-pseudo allergic activity against C48/80-induced passive cutaneous anaphylaxis mouse model assessed as body temperature loss at 10 mg/kg followed by C48/80 administration intravenously after 30 mins post-compound administration measured every 5 mins f2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID1885657Anti-pseudo allergic activity in human LAD2 cells assessed as inhibition of C48/80-induced histamine release at 0.1 to 10 uM pretreated for 30 mins followed by C48/80 addition measured after 30 mins by HPLC-MS analysis2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID1885649Anti-pseudo allergic activity against C48/80-induced passive cutaneous anaphylaxis mouse model assessed as increase in local tissue edema vascular permeability at 1 to 10 mg/kg followed by C48/80 administration after 30 mins post-compound administration m2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID1885653Anti-pseudo allergic activity in HEK293 cells expressing H1R assessed as inhibition of histamine induced calcium release at 0 to 10 uM2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID1885652Antagonist activity at MRGPRX2 (unknown origin) expressed in HEK293 cells assessed as inhibition of calcium mobilization at upto 10 uM2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID1281538Antischistosomal activity against juvenile stage of Schistosoma japonicum infected in ICR mouse assessed as reduction of parasite burden at 200 mg/kg, po administered as single dose measured after 14 days2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Antischistosomal activity of N,N'-arylurea analogs against Schistosoma japonicum.
AID1885645Anti-pseudo allergic activity in human LAD2 cells assessed as decrease in C48/80-induced calcium intracellular mobilization at 10 uM by fluorescence based assay2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID1885648Anti-pseudo allergic activity against C48/80-induced passive cutaneous anaphylaxis mouse model assessed as reduction in serum histamine level at 1 to 10 mg/kg followed by C48/80 administration intravenously after 30 mins post-compound administration measu2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID639898Antiproliferative activity against human CRL2351 cells after 5 days by SRB assay2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.
AID1281540Antischistosomal activity against adult stage of Schistosoma japonicum infected in ICR mouse assessed as reduction of parasite burden at 200 mg/kg, po administered as single dose measured after 14 days2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Antischistosomal activity of N,N'-arylurea analogs against Schistosoma japonicum.
AID1885650Anti-pseudo allergic activity against C48/80-induced passive cutaneous anaphylaxis C57 mouse model assessed as reduction in paw thickness rate at 0 to 1 mg/kg followed by C48/80 intravenously administration after 15 mins by Evans blue method2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID1281536Antischistosomal activity against juvenile stage of Schistosoma japonicum after 72 hrs by microscopy2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Antischistosomal activity of N,N'-arylurea analogs against Schistosoma japonicum.
AID1885646Anti-pseudo allergic activity in human LAD2 cells assessed as inhibition of C48/80-induced beta-hexosaminidase release2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID639894Activation of EIF2alpha kinase in human CRL2351 cells assessed as reduction in eIF2-GTP-initiator methionine tRNA ternary complex measuring increase in firefly/renilla luciferase ratio at 2.5 uM after 16 hrs by dual luciferase reporter gene assay relative2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.
AID1885643Cytotoxicity against human LAD2 cells assessed as reduction in cell viability at 10 uM incubated for 24 hrs by Cell Counting Kit assay2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID1885644Anti-pseudo allergic activity in human LAD2 cells assessed as inhibition of C48/80-induced beta-hexosaminidase release at 0.1 to 10 uM pretreated for 30 mins followed by C48/80 addition measured after 30 mins2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID1885655Anti-pseudo allergic activity against passive cutaneous anaphylaxis-induced mouse model assessed as systemic symptoms at 1 to 10 mg/kg followed by C48/80 administration after 30 mins post-compound administration measured every 5 mins for 30 mins2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID639896Antiproliferative activity against mouse KLN205 cells after 5 days by SRB assay2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.
AID1885651Anti-pseudo allergic activity against C48/80-induced passive cutaneous anaphylaxis mouse model assessed as decrease in degranulation level at 0 to 1 mg/kg followed by C48/80 addition measured after 45 mins by FITC-avidin staining based laser scanning conf2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID1885654Anti-pseudo allergic activity in HEK293 cells assessed as prevention of calcium entry in presence of emodin at 0 to 10 uM2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID1885656Anti-pseudo allergic activity against passive cutaneous anaphylaxis-induced C57 mouse model assessed as reduction in C48/80-induced extravasation rate at 0 to 1 mg/kg followed by C48/80 intravenously administration after 15 mins by Evans blue method2022Journal of medicinal chemistry, 08-11, Volume: 65, Issue:15
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents.
AID639893Aqueous solubility of compound2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.
AID639897Antiproliferative activity against human CRL2813 cells after 5 days by SRB assay2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.
AID1159589Biochemical screen of P. falciparum MAPK22016PloS one, , Volume: 11, Issue:3
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
AID1159587Biochemical screen of P. falciparum PK72016PloS one, , Volume: 11, Issue:3
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
AID1159586Biochemical screen of P. falciparum PK62016PloS one, , Volume: 11, Issue:3
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
AID1159585Biochemical screen of P. falciparum CDPK12016PloS one, , Volume: 11, Issue:3
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
AID1159588Biochemical screen of P. falciparum CDPK42016PloS one, , Volume: 11, Issue:3
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
amantadine
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source		2.1310adamantanes;
primary aliphatic amine		analgesic;
antiparkinson drug;
antiviral drug;
dopaminergic agent;
NMDA receptor antagonist;
non-narcotic analgesic
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.1310indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
praziquantel
azinox: Russian drug		2.1310isoquinolines
trimethoprim
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.. trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.		2.1310aminopyrimidine;
methoxybenzenes		antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic
tolazoline hydrochloride
[no description available]		2.1310benzenes
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		2.1310antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
emetine
Emetine: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.. emetine : A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.		2.1310isoquinoline alkaloid;
pyridoisoquinoline		antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor
2-fluoroadenine
2-fluoroadenine : An organofluorine compound that is adenine in which the hydrogen at position 2 (the carbon between the two nitrogens of the pyrimidine ring) is replaced by a fluorine.		2.1310organofluorine compound;
purines		antineoplastic agent
hydroxychloroquine sulfate
[no description available]		2.1310
c 137
C 137: RN given refers to parent cpd		2.1310
imidocarb
Imidocarb: One of ANTIPROTOZOAL AGENTS used especially against BABESIA in livestock. Toxicity has been reported.		2.1310ureasantiprotozoal drug
metoprine
metoprine: histamine methyltransferase antagonist		2.1310
parbendazole
parbendazole: anthelmintic used against a variety of gastrointestinal parasites; minor descriptor (75-86); on-line & INDEX MEDICUS search BENZIMIDAZOLES; RN given refers to parent cpd		2.1310benzimidazoles;
carbamate ester
levamisole
Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6). levamisole : A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.		2.13106-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazoleantinematodal drug;
antirheumatic drug;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
immunological adjuvant;
immunomodulator
thymolphthalein
Thymolphthalein: Used as a pH indicator and as a reagent for blood after decolorizing the alkaline solution by boiling with zinc dust.		2.1310terpene lactone
triazinate
triazinate: structure		2.1310
piritrexim
piritrexim: RN given refers to parent cpd; structure given in first source		2.1310
epiroprim
epiroprim: an analog of trimethoprim with improved antimicrobial and pharmacokinetic properties; structure given in first source		2.1310
2,2',2''-terpyridine
2,2',2''-terpyridine: RN given refers to parent cpd. 2,2':6',2''-terpyridine : A tridentate heterocyclic ligand that binds metals at three meridional sites giving two adjacent 5-membered MN2C2 chelate rings.		2.1310terpyridineschelator
chaparrinone
chaparrinone: quassinoid which inhibits protein sunthesis & DNA synthesis in cells; structure in first source		2.1310triterpenoid
thianthrene 5-oxide
thianthrene 5-oxide: used as a probe of the electrophilicity of hemoprotein oxidizing species; structure given in first source		2.1310
tryptanthrine
tryptanthrine: minor constituent of traditional Chinese medicine qing dai		2.1310alkaloid antibiotic;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound
ro 22-3581
[no description available]		2.1310
chloroquine diphosphate
[no description available]		2.1310
ethylhydrocupreine
ethylhydrocupreine: structure; RN given refers to parent cpd. optochin : A cinchona alkaloid consisting of 10,11-dihydrocinchonan bearing hydroxy and ethoxy substituents at positions 9 and 6' respectively.		2.1310aromatic ether;
cinchona alkaloid		EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
cinchonine
[no description available]		2.1310(8xi)-cinchonan-9-ol;
cinchona alkaloid		metabolite
mmv665852
MMV665852: an antischistosomal agent		2.520
wr 158122
WR 158122: structure		2.1310
3-heptyl-4-hydroxy-7-methoxy-2-methylquinoline
3-heptyl-4-hydroxy-7-methoxy-2-methylquinoline: structure given in first source		2.1310
cinchonidine
cinchonidine: has antimalarial activity; diastereoisomer of cinchonine with distinct physiochemical properties; RN given refers to parent cpd(8alpha,9R)-isomer. cinchonidine : 8-epi-Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (R configuration). A diasteroisomer of cinchonine, it occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.		2.1310(8xi)-cinchonan-9-ol;
cinchona alkaloid		metabolite
methotrexate
[no description available]		2.1310dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
my 12-62c
MY 12-62c: from Pseudomonas methanica KY4634. 2-heptyl-4-quinolone : A quinolone consisting of quinolin-4(1H)-one carrying a heptyl substituent at position 2.. 2-heptyl-4-hydroxyquinoline : A monohydroxyquinoline that is 4-hydroxyquinoline bearing an additional heptyl substituent at position 2.		2.1310monohydroxyquinoline;
quinolone		antibacterial agent;
iron chelator;
metabolite;
signalling molecule
anisomycin
Anisomycin: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.. (-)-anisomycin : An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.		2.1310monohydroxypyrrolidine;
organonitrogen heterocyclic antibiotic		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
antiparasitic agent;
bacterial metabolite;
DNA synthesis inhibitor;
protein synthesis inhibitor
quinidine
Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.		2.1310cinchona alkaloidalpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker
pseudolycorine
pseudolycorine: alkaloid isolated from Narcissus tazetta var. chinensis Roem, N. papyraceus or Lycoris radiata Herb; structure in first source		2.1310phenanthridines
jp-1302
[no description available]		2.1310
TCMDC-138263
[no description available]		2.1310harmala alkaloid
2,6-bis(benzimidazol-2-yl)pyridine
2,6-bis(benzimidazol-2-yl)pyridine: structure in first source		2.1310benzimidazoles
n-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine
N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine: an SK channel inhibitor		2.1310
2-[4-chloro-5-(cyclopentylsulfamoyl)-2-methylphenoxy]-N-cyclohexylacetamide
[no description available]		2.1310sulfonamide
stk295900
[no description available]		2.1310
6-(4-methyl-1-piperazinyl)-2-(3,4,5-trimethoxyphenyl)-1H-benzimidazole
[no description available]		2.1310benzimidazoles
1-(4-fluorophenyl)-3-[4-(4-fluorophenyl)-2-methyl-5-(trifluoromethyl)-3-pyrazolyl]urea
[no description available]		2.1310pyrazoles;
ring assembly
azoxystrobin
azoxystrobin: a methoxyacrylate analog; a strobilurin fungicide; structure given in first source. azoxystrobin : An aryloxypyrimidine having a 4,6-diphenoxypyrimidine skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture.		2.1310aryloxypyrimidine;
enoate ester;
enol ether;
methoxyacrylate strobilurin antifungal agent;
methyl ester;
nitrile		antifungal agrochemical;
environmental contaminant;
mitochondrial cytochrome-bc1 complex inhibitor;
quinone outside inhibitor;
xenobiotic
trequinsin hydrochloride
[no description available]		2.1310
abbott 41988
Abbott 41988: tetrahydropyridobenzopyran derived from cannabinoid nucleus; structure		2.1310
N-[4-(1H-benzimidazol-2-yl)phenyl]-4-ethoxy-3-nitrobenzamide
[no description available]		2.1310benzimidazoles
2-[2-methoxyethyl-(1-oxo-2-thiophen-2-ylethyl)amino]-N-[(4-methoxyphenyl)methyl]-2-(4-propan-2-ylphenyl)acetamide
[no description available]		2.1310monoterpenoid
7-chloro-N-(phenylmethyl)-4-quinolinamine
[no description available]		2.1310aminoquinoline
5-[(5-bromo-2-hydroxyphenyl)-oxomethyl]-1-cyclohexyl-2-oxo-3-pyridinecarbonitrile
[no description available]		2.1310aromatic ketone
imd 0354
N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide: a cardioprotective agent that inhibits IkappaB kinase beta (IKKbeta); structure in first source		2.1310benzamides
daphnetin
[no description available]		2.1310hydroxycoumarin
hispidulin
hispidulin : A monomethoxyflavone that is scutellarein methylated at position 6.		2.1310monomethoxyflavone;
trihydroxyflavone		anti-inflammatory agent;
anticonvulsant;
antineoplastic agent;
antioxidant;
apoptosis inducer;
plant metabolite
morusin
morusin: from Morus root bark; structure given in first source. morusin : An extended flavonoid that is flavone substituted by hydroxy groups at positions 5, 2' and 4', a prenyl group at position 3 and a 2,2-dimethyl pyran group across positions 7 and 8.		2.1310extended flavonoid;
trihydroxyflavone		antineoplastic agent;
plant metabolite
olvanil
[no description available]		2.1310methoxybenzenes;
phenols
pd 166285
[no description available]		2.1310
pd-173952
[no description available]		2.1310
10-hydroxy-3-methyl-8-pentyl-2,4-dihydro-1H-[1]benzopyrano[3,4-c]pyridin-5-one
[no description available]		2.1310pyridochromene
bvt.948
[no description available]		2.1310
artesunate
artesunic acid: RN given for (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,(2aR*))-isomer; succinic ester of artemether		2.1310artemisinin derivative;
cyclic acetal;
dicarboxylic acid monoester;
hemisuccinate;
semisynthetic derivative;
sesquiterpenoid		antimalarial;
antineoplastic agent;
ferroptosis inducer
edatrexate
edatrexate: structure given in first source		2.1310glutamic acid derivative
pq 401
PQ 401: an IGF receptor type I antagonist; structure in first source		2.1310quinolines
nik 12192
4-(5,6-dichloro-1H-indol-2-yl)-3-ethoxy-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide: structure in first source		2.1310
zm 447439
ZM447439 : A member of the class of quinazolines that is quinazoline which is substituted at positions 4, 6 and 7 by a (4-benzamidophenyl)nitrilo group, methoxy group and a 3-(morpholin-4-yl)propoxy group, respectively. It is an ATP-competitive inhibitor of Aurora A and Aurora B kinases with IC50 of 110 nM and 130 nM, respectively.		2.1310aromatic ether;
benzamides;
morpholines;
polyether;
quinazolines;
secondary amino compound;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
Aurora kinase inhibitor
pha 665752
[no description available]		2.1310dichlorobenzene;
enamide;
indolones;
N-acylpyrrolidine;
pyrrolecarboxamide;
secondary carboxamide;
sulfone;
tertiary carboxamide		antineoplastic agent;
c-Met tyrosine kinase inhibitor
zstk474
ZSTK-474 : A triamino-1,3,5-triazine that is 1,3,5-triazine in which two of the hydrogens have been replaced by morpholin-4-yl groups while the third hydrogen has been replaced by a 2-(difluoromethyl)benzimidazol-1-yl group. It is an inhibitor of phosphatidylinositol 3-kinase.		2.1310benzimidazoles;
morpholines;
organofluorine compound;
triamino-1,3,5-triazine		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
brl 15572
BRL 15572: specific for h5-HT(1D) receptors; structure in first source. 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride : A hydrochloride that is the monohydrochloride salt of 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol. A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.		2.1310hydrochlorideprodrug;
serotonergic antagonist
amodiaquine hydrochloride
[no description available]		2.1310
puromycin dihydrochloride
[no description available]		2.1310
au-1
[no description available]		2.1310
1-[amino-[(6-methoxy-4-methyl-2-quinazolinyl)amino]methylidene]-3-phenylurea
[no description available]		2.1310quinazolines
1843u89
1843U89: structure given in first source; a folate analog		2.1310
hesperadin
[no description available]		2.1310
cb 3717
[no description available]		2.1310N-acyl-L-glutamic acid
cb 3705
CB 3705: inhibitor of dihydrofolate reductase & thymidylate synthetase		2.1310
ConditionIndicatedRelationship StrengthStudiesTrials
Plasmodium falciparum Malaria
[description not available]		02.1310
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.1310
Anaphylactic Reaction
[description not available]		02.4110
Anaphylaxis
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.		02.4110