retinol-acetate and Hypervitaminosis-A

Perisinusoidal fibrosis development in experimental hypervitaminosis A and its combination with preliminary Kupffer cells stimulation with prodigiozan was studied in rat liver using light and electron microscopy. Reticular fibers volume density naturally growing after administration of large dozes of vitamin A, significantly reduces in appropriate terms of experiment after Kupffer cells stimulation with prodigiozan. Two cell type were distinguished in perisinusoidal space: typical fat-accumulating ones and fibroblast-like ones topographically closely connected with reticuline fibres. Endotheliocytes and Kupffer cells acquire dystrophic changes in prodigiozan introduction and hypervitaminosis A combination.

Topics: Animals; Anti-Bacterial Agents; Diterpenes; Female; Hypervitaminosis A; Kupffer Cells; Liver; Liver Cirrhosis, Experimental; Microscopy, Electron; Prodigiozan; Rats; Retinyl Esters; Stimulation, Chemical; Time Factors; Vitamin A

We studied the relationships of supplemental and total vitamin A and supplemental vitamin E intake with fasting plasma biochemical indicators of vitamin A and vitamin E nutritional status among 562 healthy elderly people (aged 60-98 y) and 194 healthy young adult (aged 19-59 y) volunteers. All subjects were nonsmokers. For the young adults, plasma retinol was significantly greater in males than in females (p less than 0.01); retinol was not related to supplemental vitamin A intake for either group. Fasting plasma retinyl esters demonstrated a significant increase with vitamin A supplement use. For supplemental vitamin A intakes of 5001-10,000 IU/d, a 2.5-fold increase over nonusers in fasting plasma retinyl esters was observed for elderly people (p less than 0.05) and a 1.5-fold increase for young adults (p greater than 0.20). For elderly people, greater fasting plasma retinyl esters were associated with long-term vitamin A supplement use (greater than 5 y) and biochemical evidence of liver damage. Elderly people who take vitamin A supplements may be at increased risk for vitamin A overload.

Topics: Aged; Aged, 80 and over; Aging; Carotenoids; Cholesterol; Diterpenes; Fasting; Female; Food, Fortified; Humans; Hypervitaminosis A; Male; Middle Aged; Retinol-Binding Proteins; Retinol-Binding Proteins, Plasma; Retinyl Esters; Vitamin A; Vitamin E

Topics: Animals; Chick Embryo; Diterpenes; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryo, Nonmammalian; Hypervitaminosis A; Retinyl Esters; Time Factors; Vitamin A