Empty Sella Syndrome

A condition when the SELLA TURCICA is not filled with pituitary tissue. The pituitary gland is either compressed, atrophied, or removed. There are two types: (1) primary empty sella is due a defect in the sella diaphragm leading to arachnoid herniation into the sellar space; (2) secondary empty sella is associated with the removal or treatment of PITUITARY NEOPLASMS.

Synonym
Empty Sella Syndrome, Primary
Primary Empty Sella Syndrome
Secondary Empty Sella Syndrome
Empty Sella Turcica Syndrome
Empty Sella Turcica
Empty Sella Syndrome, Secondary
Empty Sella Syndrome

Excerpt	Reference
"Empty sella syndrome is an anatomoclinical condition in which the herniation of the chiasmatic cavities inside the sella turcica causes deformation of the bone and compression of the hypophysis and its peduncle, often in association with neurological and endocrine symptoms."	( Buonaguidi, R; Faggionato, F; Ferdeghini, M; Lutzemberger, L; Puglioli, M, 1984)
"Empty sella syndrome is sometimes associated with anterior pituitary insufficiency, the latter being mostly partial or dissociated."	( Algayres, JP; Bechade, D; Bili, H; Ceccaldi, B; Coutant, G; Daly, JP; Schmoor, P; Soulié, B, 1998)
"A case of empty sella syndrome is presented."	( Weiss, RE, 2003)

Excerpt	Reference
"Over recent years empty sella turcica has become more frequently diagnosed with high resolution computerized tomography and the associated clinical abnormalities have been better described."	( Alford, FP; Best, JD; Gilford, EJ; Henderson, JK; Murphy, MA; Ramos, RF, 1988)

Excerpt	Reference
"6 cases of the primary empty sella syndrome, 5 boys and 1 girl aged from 1 to 22 years, are being treated."	( Glatzl, J; Unsinn, K, 1991)
"We present the case of a woman with 'empty sella syndrome' who experienced generalized urticaria after the administration of sodium succinate hydrocortisone in two episodes."	( Aruanno, A; Buonomo, A; Colagiovanni, A; de Pasquale, T; Lombardo, C; Nucera, E; Pascolini, L; Pecora, V; Ricci, AG; Rizzi, A; Sabato, V; Schiavino, D, 2011)
"Chiasmapexy is performed to treat empty sella syndrome."	( Ishihara, E; Ogawa, K; Ozawa, H; Saito, S; Sasao, R; Toda, M; Yoshida, K, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	75 (40.11)	23.3326
1990's	42 (22.46)	12.5806
2000's	32 (17.11)	18.1394
2010's	31 (16.58)	28.8240
2020's	7 (3.74)	9.53

Drug	Relationship Strength	Studies	Trials
glycine	low	1	0
glycocyamine	low	1	0
thiamine	low	1	0
acetazolamide	low	2	0
aminoglutethimide	low	1	0
chlorpromazine	low	1	0
pentetic acid	low	2	0
domperidone	low	1	0
indomethacin	low	1	0
iodamide	low	1	0
iothalamic acid	low	3	0
iodipamide	low	1	0
2-propanol	low	1	0
ketoconazole	low	1	0
meperidine	low	1	0
metoclopramide	low	4	0
metyrapone	low	1	0
nomifensine	low	1	0
prochlorperazine	low	1	0
corticosterone	low	1	0
prednisolone	low	2	0
thyroxine	low	22	0
spironolactone	low	1	0
prednisone	low	2	0
triiodothyronine	low	3	0
lysine	low	1	0
levodopa	low	5	0
tyrosine	low	1	0
17-alpha-hydroxyprogesterone	medium	1	1
medroxyprogesterone acetate	low	1	0
tryptophan	low	1	0
arginine	low	4	0
methylprednisolone	low	3	0
meglumine	low	1	0
betamethasone	low	2	0
gadolinium	low	2	0
magnesium sulfate	low	1	0
trolamine salicylate	low	1	0
metergoline	low	1	0
bromocriptine	low	20	0
propiconazole	low	2	0
cabergoline	low	5	0
iopamidol	low	4	0
dityrosine	low	1	0
methotrexate	low	1	0
cortisone	low	3	0
oxytocin	low	1	0
metrizamide	low	24	0
meglumine iodipamide	low	1	0
lypressin	low	1	0
arginine vasopressin	low	3	0
etomidate	low	1	0
enclomiphene	low	1	0
lithium	low	1	0
quinagolide	low	1	0
6-nitrotryptophan	low	1	0
17-ketosteroids	low	3	0
cholecalciferol	low	1	0
phenylephrine hydrochloride	low	2	0
naloxone	low	1	0
deamino arginine vasopressin	low	3	0
gadolinium dtpa	low	1	0
ergoline	low	4	0
pituitrin	low	4	0
atrial natriuretic factor	low	1	0
(dtpa-phe(1))-octreotide	low	1	0
c-peptide	low	2	0
hydrocortisone sodium phosphate	low	1	0
19-iodocholesterol	low	1	0
sodium pertechnetate tc 99m	low	1	0
cortisol succinate, sodium salt	low	1	0
warfarin	low	1	0
68ga-dotanoc	low	1	0
rifampin	low	1	0
8-hydroxy-2'-deoxyguanosine	low	1	0
carbidopa	low	1	0
leptin	low	1	0

Protein Targets (866)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
acetylcholinesterase	9	0	0	9
pregnane X receptor	8	0	0	8
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
TDP1 protein	22	0	0	22
GLI family zinc finger 3	21	0	0	21
Microtubule-associated protein tau	9	0	0	9
AR protein	28	0	0	28
progesterone receptor	17	0	0	17
glucocorticoid receptor [Homo sapiens]	27	0	0	27
retinoic acid nuclear receptor alpha variant 1	15	0	0	15
retinoid X nuclear receptor alpha	17	0	0	17
estrogen-related nuclear receptor alpha	23	0	0	23
farnesoid X nuclear receptor	12	0	0	12
pregnane X nuclear receptor	22	0	0	22
estrogen nuclear receptor alpha	34	0	0	34
G	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	18	0	0	18
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	17	0	0	17
activating transcription factor 6	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
chromobox protein homolog 1	18	0	0	18
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
geminin	19	0	0	19
survival motor neuron protein isoform d	10	0	0	10
histone acetyltransferase KAT2A isoform 1	5	0	0	5
lamin isoform A-delta10	19	0	0	19
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Interferon beta	11	0	0	11
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Glucocorticoid receptor	0	16	4	25
Sex hormone-binding globulin	0	0	4	4
Glycine receptor subunit alpha-1	0	16	0	16
Corticosteroid-binding globulin	0	4	0	4
Adenosine receptor A3	0	4	0	4
Replicase polyprotein 1ab	0	2	1	3
Androgen receptor	0	13	0	14
Alpha-1B adrenergic receptor	0	10	0	10
Glutamate receptor 2	11	0	0	11
Glycine receptor subunit beta	0	16	0	16
Glycine receptor subunit alpha-2	0	16	0	16
Glycine receptor subunit alpha-3	0	16	0	16
Mitogen-activated protein kinase 3	0	1	0	1
Alpha-1A adrenergic receptor	0	10	1	11
Sodium-dependent dopamine transporter	0	14	0	14
TAR DNA-binding protein 43	4	0	0	4
Inositol hexakisphosphate kinase 1	8	0	0	8
cytochrome P450 2C9, partial	8	0	0	8
ATP-dependent phosphofructokinase	10	0	0	10
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	19	0	0	19
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
peroxisome proliferator-activated receptor delta	14	0	0	14
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Histone H2A.x	6	0	0	6
thyroid hormone receptor beta isoform a	11	0	0	11
heat shock protein beta-1	5	0	0	5
Chain A, Avidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain B, Avidin	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	8	0	0	8
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	17	0	0	17
GALC protein	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Bloom syndrome protein isoform 1	7	0	0	7
peripheral myelin protein 22	14	0	0	14
muscleblind-like protein 1 isoform 1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	11	2	1	14
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	19	0	20
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	2	1	8
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	27	0	27
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	3	1	11
Carbonic anhydrase 2	0	3	2	11
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	3	1	4
Carbonic anhydrase 3	0	2	1	8
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	7	0	9
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	8	0	10
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	3	0	3
Cytochrome P450 2D6	0	11	1	12
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	5	0	5
5-hydroxytryptamine receptor 2A	0	9	0	9
Gamma-aminobutyric acid receptor subunit beta-1	11	2	1	14
Translocator protein	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	11	2	1	14
Gamma-aminobutyric acid receptor subunit gamma-2	11	2	1	14
Gamma-aminobutyric acid receptor subunit alpha-5	11	2	1	14
Gamma-aminobutyric acid receptor subunit alpha-3	11	2	1	14
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Carbonic anhydrase 4	0	2	1	7
Carbonic anhydrase 6	0	3	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	11	2	1	14
Gamma-aminobutyric acid receptor subunit alpha-2	11	2	1	14
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	0	4
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	11	2	1	14
Gamma-aminobutyric acid receptor subunit gamma-3	11	2	1	14
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	11	2	1	14
Adenosine receptor A2a	0	2	1	5
5-hydroxytryptamine receptor 2B	0	7	0	7
Sodium-dependent serotonin transporter	0	4	0	4
Delta-type opioid receptor	0	6	1	8
Cytochrome P450 2C19	0	4	0	4
Delta-type opioid receptor	0	4	2	6
Mu-type opioid receptor	0	4	2	6
Carbonic anhydrase 5A, mitochondrial	0	2	1	8
Carbonic anhydrase	0	1	0	4
Kappa-type opioid receptor	0	3	1	4
Carbonic anhydrase 7	0	2	1	7
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	4
D(2) dopamine receptor	0	11	1	14
Gamma-aminobutyric acid receptor subunit alpha-1	11	2	1	14
Gamma-aminobutyric acid receptor subunit beta-3	11	2	1	14
Gamma-aminobutyric acid receptor subunit beta-2	11	2	1	14
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	5	1	6
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	4	1	8
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	2	1	8
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	1	3
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	11	2	1	14
Canalicular multispecific organic anion transporter 1	0	19	0	19
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 15	0	1	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	2	0	5
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	11	2	1	14
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	2	1	8
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	1	8
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
IDH1	14	0	0	14
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
peripheral myelin protein 22 isoform 1	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
transcriptional regulator ERG isoform 3	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
cytochrome P450 3A4 isoform 1	11	0	0	11
Sterol O-acyltransferase 1	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Triosephosphate isomerase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	4	0	4
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Aromatase	0	5	0	9
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Aromatase	0	1	1	2
Thromboxane-A synthase	0	3	0	3
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	9	0	0	9
NFKB1 protein, partial	5	0	0	5
GLS protein	8	0	0	8
thyroid stimulating hormone receptor	7	0	0	7
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	5	0	0	5
flap endonuclease 1	7	0	0	7
DNA polymerase iota isoform a (long)	10	0	0	10
muscarinic acetylcholine receptor M1	10	0	0	10
lethal factor (plasmid)	4	0	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
vitamin D3 receptor isoform VDRA	8	0	0	8
Vasopressin V2 receptor	0	4	3	8
Oxytocin receptor	0	3	4	7
Vasopressin V1a receptor	0	1	2	3
Vasopressin V1a receptor	0	4	3	7
Vasopressin V1b receptor	0	3	3	6
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	2	1	4
Translocator protein	0	2	0	3
Oxytocin receptor	0	2	0	2
Vasopressin V2 receptor	0	3	2	5
Atrial natriuretic peptide receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
aryl hydrocarbon receptor	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
galanin receptor type 3	0	1	0	1
ORF73	0	0	1	1
Genome polyprotein	0	1	1	2
dopamine D1 receptor	4	0	0	4
ATAD5 protein, partial	8	0	0	8
Fumarate hydratase	4	0	0	4
regulator of G-protein signaling 4	7	0	0	7
polyprotein	4	0	0	4
peroxisome proliferator activated receptor gamma	15	0	0	15
D(1A) dopamine receptor	6	0	0	6
thyroid hormone receptor beta isoform 2	18	0	0	18
serine/threonine-protein kinase mTOR isoform 1	7	0	0	7
5-hydroxytryptamine receptor 4	0	16	0	16
Cellular tumor antigen p53	20	0	0	20
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	6	0	8
Beta-1 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	6	3	10
Alpha-2A adrenergic receptor	0	20	1	22
D(2) dopamine receptor	0	14	1	17
Alpha-2B adrenergic receptor	0	18	1	20
Alpha-2C adrenergic receptor	0	16	1	18
D	0	7	0	8
D(3) dopamine receptor	0	8	0	9
5-hydroxytryptamine receptor 1A	0	14	0	14
Alpha-2B adrenergic receptor	0	7	0	7
ATP-dependent translocase ABCB1	0	3	0	3
D(1A) dopamine receptor	0	10	0	12
Alpha-2C adrenergic receptor	0	7	0	7
Alpha-2A adrenergic receptor	0	7	0	7
Alpha-1D adrenergic receptor	0	14	1	16
D(1B) dopamine receptor	0	6	0	6
5-hydroxytryptamine receptor 2A	0	16	1	18
5-hydroxytryptamine receptor 2C	0	16	1	17
5-hydroxytryptamine receptor 1B	0	16	0	16
D(4) dopamine receptor	0	6	0	6
D(3) dopamine receptor	0	16	0	17
Alpha-synuclein	2	2	0	4
5-hydroxytryptamine receptor 2B	0	17	1	19
5-hydroxytryptamine receptor 6	0	11	0	12
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	12	0	0	12
cytochrome P450 2D6	9	0	0	9
thyroid stimulating hormone receptor	9	0	0	9
Spike glycoprotein	14	1	1	16
Histamine H3 receptor	0	3	0	3
Proteasome subunit beta type-11	0	0	0	1
USP1 protein, partial	9	0	0	9
Thrombopoietin	4	0	0	4
Smad3	7	0	0	7
caspase 7, apoptosis-related cysteine protease	2	0	0	2
estrogen receptor 2 (ER beta)	7	0	0	7
NADPH oxidase 1	0	1	0	1
67.9K protein	5	0	0	5
Snq2p	0	0	0	2
caspase-3	2	0	0	2
Adenylate cyclase type 1	0	2	0	2
Caspase-7	1	0	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
cytochrome P450 2D6 isoform 1	7	0	0	7
cellular tumor antigen p53 isoform a	4	0	0	4
caspase-3	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
mitogen-activated protein kinase 1	6	0	0	6
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
DNA polymerase kappa isoform 1	7	0	0	7
M-phase phosphoprotein 8	10	0	0	10
Proteasome subunit alpha type-7	0	0	0	1
Solute carrier family 22 member 1	0	10	0	12
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
Transmembrane protease serine 2	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Bile salt export pump	0	6	0	6
Potassium channel subfamily K member 2	0	1	0	1
Epidermal growth factor receptor	0	4	0	4
Albumin	0	1	4	5
Albumin	0	0	4	4
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Major prion protein	0	0	1	1
Integrin beta-3	4	0	0	4
Tyrosine-protein kinase Fyn	0	4	0	4
Procathepsin L	0	2	1	3
Aldo-keto reductase family 1 member B1	0	12	0	12
Muscarinic acetylcholine receptor M2	0	9	0	10
Muscarinic acetylcholine receptor M4	0	7	0	8
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Integrin alpha-IIb	4	0	0	4
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M5	0	7	0	7
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M1	0	7	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Angiotensin-converting enzyme	0	6	0	6
Sphingomyelin phosphodiesterase	0	1	0	1
D(2) dopamine receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	8	0	9
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	8	0	8
D(4) dopamine receptor	0	5	0	7
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-1D adrenergic receptor	0	6	0	6
Sodium-dependent noradrenaline transporter	0	14	0	15
Sodium-dependent dopamine transporter	0	7	0	7
Histamine H2 receptor	0	10	0	11
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	2	0	2
Histamine H1 receptor	0	2	1	3
Sodium-dependent serotonin transporter	0	15	0	16
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	4	0	4
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 7	0	3	0	4
Histamine H1 receptor	0	10	0	11
Mu-type opioid receptor	0	7	2	10
Glutamate receptor ionotropic, NMDA 1	0	3	1	7
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	7	1	10
Kappa-type opioid receptor	0	7	2	10
Melanocortin receptor 3	0	2	0	2
Histamine H2 receptor	9	0	0	9
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
5-hydroxytryptamine receptor 7	0	4	0	4
Cytochrome P450 2J2	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	1	1	2
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	7
Glutamate receptor ionotropic, NMDA 2C	0	3	1	7
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	12	0	12
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	1	7
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	1	7
D	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	9	0	9
Angiotensin-converting enzyme 2	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	1	7
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, Ferritin light chain	4	0	0	4
Chain A, Cruzipain	5	0	0	5
Luciferase	3	0	0	3
interleukin 8	4	0	0	4
15-lipoxygenase, partial	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	8	0	0	8
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Vitamin D3 receptor	0	1	1	4
Glycine receptor subunit alpha-1	0	0	3	3
Vitamin D3 receptor	0	0	1	1
Nuclear receptor ROR-gamma	5	0	0	5
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2C9 precursor	2	0	0	2
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	3	0	3
Alpha-1A adrenergic receptor	0	0	1	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Adenosine receptor A2b	0	0	1	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	3	1	5
Alpha-1B adrenergic receptor	0	2	1	4
Inositol monophosphatase 1	2	0	0	2
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	4	0	4
Multidrug and toxin extrusion protein 1	0	6	0	6
Nischarin	0	1	0	1
nonstructural protein 1	6	0	0	6
Solute carrier family 22 member 2	0	3	0	3
Solute carrier family 22 member 3	0	1	0	1
Mineralocorticoid receptor	0	5	2	8
C-8 sterol isomerase	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
Solute carrier family 22 member 2	0	3	0	3
Rap guanine nucleotide exchange factor 3	2	0	0	2
endonuclease IV	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
EWS/FLI fusion protein	8	0	0	8
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Retinoic acid receptor RXR-alpha	0	0	3	3
5-hydroxytryptamine receptor 3A	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
5-hydroxytryptamine receptor 3B	0	4	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
glp-1 receptor, partial	7	0	0	7
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Estrogen receptor	0	7	2	9
Beta-3 adrenergic receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Cytochrome P450 11B1, mitochondrial	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Cytochrome P450 11B2, mitochondrial	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Transporter	0	3	0	3
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	4	0	4
Proton-coupled amino acid transporter 1	0	2	0	2
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
glucocerebrosidase	3	0	0	3
Parkin	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
neuropeptide S receptor isoform A	4	0	0	4
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	4	0	4
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Interleukin-8	0	1	0	1
Androgen receptor	0	7	4	11
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	1	0	2
Substance-P receptor	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	3	1	4
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	5	5
Aldo-keto reductase family 1 member C3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	2	0	2
Guanine nucleotide-binding protein G	3	0	0	3
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	4
Prostaglandin G/H synthase 2	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	7
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	4	0	7
Estrogen receptor beta	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	3	0	3
Cytochrome P450 7A1	0	1	0	1
Estrogen receptor	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	1	4
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
apical membrane antigen 1, AMA1	5	0	0	5
pyruvate kinase	2	0	0	2
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
DNA polymerase eta isoform 1	4	0	0	4
Polyphenol oxidase 2	0	0	0	2
Plasma kallikrein	0	0	0	3
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	3
Carbonic anhydrase-like protein, putative	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
phosphoglycerate kinase	1	0	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
PINK1	1	0	0	1
Progesterone receptor	0	6	2	9
Androgen receptor	0	0	1	1
Estrogen receptor beta	0	4	2	6
Liver carboxylesterase 1	0	0	0	1
Kappa-type opioid receptor	0	2	0	3
Mu-type opioid receptor	0	2	0	3
RGS12	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Endothelin receptor type B	0	1	0	1
Acetylcholinesterase	0	2	0	2
Endothelin receptor type B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
5-hydroxytryptamine receptor 1B	0	0	0	1
5-hydroxytryptamine receptor 1D	0	3	0	3
5-hydroxytryptamine receptor 1E	0	0	0	1
5-hydroxytryptamine receptor 1F	0	3	0	3
Kappa-type opioid receptor	0	2	2	5
Prostaglandin E2 receptor EP4 subtype	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	0	0	1
5-hydroxytryptamine receptor 3A	0	0	1	2
5-hydroxytryptamine receptor 5A	0	0	0	1
5-hydroxytryptamine receptor 4	0	0	0	1
Histamine H4 receptor	0	0	0	1
Heparanase	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
PPM1D protein	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
5-hydroxytryptamine receptor 3E	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Myeloperoxidase	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	3
5-hydroxytryptamine receptor 3D	0	0	1	1
5-hydroxytryptamine receptor 3C	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Adenosine receptor A1	0	3	0	3
Beta-2 adrenergic receptor	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Transporter	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Oxytocin receptor	0	0	1	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	2	0	0	2
5-hydroxytryptamine receptor 2A	0	0	1	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
thioredoxin glutathione reductase	2	0	0	2
Mcl-1	0	1	0	1
neutrophil cytosol factor 1	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	4
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	1	0	3
Glutathione S-transferase omega-1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
serine/threonine-protein kinase PLK1	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Prothrombin	0	0	1	1
Thyroid hormone receptor beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(7)

Research Excerpts

Overview

Context

Treatment

Research

Studies (187)

Protein Targets (866)

Empty Sella Syndrome

Synonyms(7)

Research Excerpts

Overview

Context

Treatment

Research

Studies (187)

Drugs Studied (92)

Protein Targets (866)