c-peptide and Empty-Sella-Syndrome

c-peptide has been researched along with Empty-Sella-Syndrome* in 2 studies

Other Studies

2 other study(ies) available for c-peptide and Empty-Sella-Syndrome

Article	Year
Growth hormone deficiency and empty sella in DIDMOAD syndrome: an endocrine study. Archives of disease in childhood, 1995, Volume: 73, Issue:3 Two girls with DIDMOAD syndrome are presented. One also had severe megaloblastic-sideroblastic anaemia and the other several neurological manifestations. Both were short with defective growth hormone secretion. Computed tomography revealed empty sella in both girls; one had widespread atrophic cortical and cerebellar changes. High doses of thiamine improved the anaemia in the first case, increased C peptide secretion in both, but had no effect on the neurological abnormalities. Topics: Anemia, Sideroblastic; C-Peptide; Empty Sella Syndrome; Female; Growth Hormone; Humans; Infant; Nervous System Diseases; Thiamine; Tomography, X-Ray Computed; Wolfram Syndrome	1995
A case of autoimmune insulin antibody syndrome associated with polymyositis, empty sella and apparent high urinary output of immunoreactive insulin. Endocrinologia japonica, 1992, Volume: 39, Issue:3 Patients with autoimmune insulin antibody are characterized by hypoglycemic attacks and antibodies to insulin in serum without prior insulin administration. In the present report, a patient with hypoglycemia due to autoimmune insulin antibody associated with primary empty sella syndrome and polymyositis appeared to have high urinary immunoreactive insulin (IRI) in the face of normal urinary C peptide. Consequently, the urinary IRI/C peptide ratio was apparently high. The amelioration of hypoglycemic attacks and polymyositis by prednisolone treatment was accompanied by the disappearance of the antibodies and complete normalization of the urinary IRI and IRI/C peptide ratio. No comparable rise in the urinary IRI and IRI/C peptide ratio was observed in the patients with other disorders studied. Glucose clamp and glucose tolerance study showed decreased sensitivity to exogenous or newly secreted insulin, prolonged half disappearance time of serum insulin, and normal disappearance of blood glucose. These results were consistent with the idea that autoantibodies buffered the effect of exogenous or newly secreted insulin and maintained a relatively constant level of serum free insulin which was not high enough when a large amount of glucose was loaded, but was too high after prolonged fasting, which eventually caused hypoglycemic attacks. Topics: Autoantibodies; Autoimmune Diseases; Blood Glucose; C-Peptide; Child; Empty Sella Syndrome; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Insulin Antibodies; Middle Aged; Muscles; Myositis; Prednisolone; Time Factors	1992

Article

Year

Growth hormone deficiency and empty sella in DIDMOAD syndrome: an endocrine study.

Archives of disease in childhood, 1995, Volume: 73, Issue:3

Two girls with DIDMOAD syndrome are presented. One also had severe megaloblastic-sideroblastic anaemia and the other several neurological manifestations. Both were short with defective growth hormone secretion. Computed tomography revealed empty sella in both girls; one had widespread atrophic cortical and cerebellar changes. High doses of thiamine improved the anaemia in the first case, increased C peptide secretion in both, but had no effect on the neurological abnormalities.

Topics: Anemia, Sideroblastic; C-Peptide; Empty Sella Syndrome; Female; Growth Hormone; Humans; Infant; Nervous System Diseases; Thiamine; Tomography, X-Ray Computed; Wolfram Syndrome

1995

A case of autoimmune insulin antibody syndrome associated with polymyositis, empty sella and apparent high urinary output of immunoreactive insulin.

Endocrinologia japonica, 1992, Volume: 39, Issue:3

Patients with autoimmune insulin antibody are characterized by hypoglycemic attacks and antibodies to insulin in serum without prior insulin administration. In the present report, a patient with hypoglycemia due to autoimmune insulin antibody associated with primary empty sella syndrome and polymyositis appeared to have high urinary immunoreactive insulin (IRI) in the face of normal urinary C peptide. Consequently, the urinary IRI/C peptide ratio was apparently high. The amelioration of hypoglycemic attacks and polymyositis by prednisolone treatment was accompanied by the disappearance of the antibodies and complete normalization of the urinary IRI and IRI/C peptide ratio. No comparable rise in the urinary IRI and IRI/C peptide ratio was observed in the patients with other disorders studied. Glucose clamp and glucose tolerance study showed decreased sensitivity to exogenous or newly secreted insulin, prolonged half disappearance time of serum insulin, and normal disappearance of blood glucose. These results were consistent with the idea that autoantibodies buffered the effect of exogenous or newly secreted insulin and maintained a relatively constant level of serum free insulin which was not high enough when a large amount of glucose was loaded, but was too high after prolonged fasting, which eventually caused hypoglycemic attacks.

Topics: Autoantibodies; Autoimmune Diseases; Blood Glucose; C-Peptide; Child; Empty Sella Syndrome; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Insulin Antibodies; Middle Aged; Muscles; Myositis; Prednisolone; Time Factors

1992