4-nitroquinoline-1-oxide has been researched along with Bloom Syndrome in 4 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
Bloom Syndrome: An autosomal recessive disorder characterized by telangiectatic ERYTHEMA of the face, photosensitivity, DWARFISM and other abnormalities, and a predisposition toward developing cancer. The Bloom syndrome gene (BLM) encodes a RecQ-like DNA helicase.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fibroblasts of a patient with Bloom syndrome (GM-1492) were cultured in the presence of either mitomycin C, ethylmethanesulfonate, or 4-nitroquinoline-1-oxide, (4-NQ1-O) and sister chromatid exchange was determined." | 3.66 | Mutagen-induced sister chromatid exchange rate in Bloom syndrome remains unaltered in the presence of Bloom corrective factor. ( Bartram, CR; Maack, P; Rüdiger, HW; Schmidt-Preuss, U, 1981) |
| "Werner's syndrome (WS) and Bloom's syndrome (BS) are rare autosomal genetic diseases that predispose to cancer and are associated with genomic instability." | 1.31 | Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients. ( Furuichi, Y; Goto, M; Hayashi, M; Honma, M; Sakamoto, H; Satoh, T; Sofuni, T; Sugimoto, M; Tadokoro, S; Tanabe, H, 2002) |
| "Chromosomal aberrations were also synergistically increased in WRN(-/-)/BLM(-/-) cells when irradiated with UV light in late S to G(2) phases." | 1.31 | Werner and Bloom helicases are involved in DNA repair in a complementary fashion. ( Fujita, K; Furuichi, Y; Imamura, O; Itoh, C; Matsumoto, T; Takeda, S, 2002) |
| "The two Bloom's syndrome cell lines and 46BR cells had a nearly normal ability to reseal breaks resulting from gamma irradiation or treatment with xanthine plus xanthine oxidase." | 1.29 | Comet assay analysis of repair of DNA strand breaks in normal and deficient human cells exposed to radiations and chemicals. Evidence for a repair pathway specificity of DNA ligation. ( Nocentini, S, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Honma, M | 1 |
| Tadokoro, S | 1 |
| Sakamoto, H | 1 |
| Tanabe, H | 1 |
| Sugimoto, M | 1 |
| Furuichi, Y | 2 |
| Satoh, T | 1 |
| Sofuni, T | 1 |
| Goto, M | 1 |
| Hayashi, M | 1 |
| Schmidt-Preuss, U | 1 |
| Maack, P | 1 |
| Bartram, CR | 1 |
| Rüdiger, HW | 1 |
| Nocentini, S | 1 |
| Imamura, O | 1 |
| Fujita, K | 1 |
| Itoh, C | 1 |
| Takeda, S | 1 |
| Matsumoto, T | 1 |
4 other studies available for 4-nitroquinoline-1-oxide and Bloom Syndrome
| Article | Year |
|---|---|
Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients.
Topics: 4-Nitroquinoline-1-oxide; B-Lymphocytes; Bloom Syndrome; Camptothecin; Carcinogens; Case-Control Stu | 2002 |
Mutagen-induced sister chromatid exchange rate in Bloom syndrome remains unaltered in the presence of Bloom corrective factor.
Topics: 4-Nitroquinoline-1-oxide; Adult; Bloom Syndrome; Cell Line; Cells, Cultured; Crossing Over, Genetic; | 1981 |
Comet assay analysis of repair of DNA strand breaks in normal and deficient human cells exposed to radiations and chemicals. Evidence for a repair pathway specificity of DNA ligation.
Topics: 4-Nitroquinoline-1-oxide; Bloom Syndrome; Cells, Cultured; DNA; DNA Damage; DNA Ligases; DNA Repair; | 1995 |
Werner and Bloom helicases are involved in DNA repair in a complementary fashion.
Topics: 4-Nitroquinoline-1-oxide; Adenosine Triphosphatases; Amino Acid Sequence; Animals; B-Lymphocytes; Bl | 2002 |