bisbenzimidazole has been researched along with Bloom Syndrome in 3 studies
Bisbenzimidazole: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.
Bloom Syndrome: An autosomal recessive disorder characterized by telangiectatic ERYTHEMA of the face, photosensitivity, DWARFISM and other abnormalities, and a predisposition toward developing cancer. The Bloom syndrome gene (BLM) encodes a RecQ-like DNA helicase.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cells from Bloom's syndrome, a rare autosomal recessive disorder characterized by pre- and post-natal growth deficits, telangiectatic erythema, recurrent respiratory infections and a high incidence of cancer, exhibit in culture a hypersensitivity to BrdU." | 1.28 | Detection of free radical-induced DNA damage with bromodeoxyuridine/Hoechst flow cytometry: implications for Bloom's syndrome. ( Hoehn, H; Poot, M; Rüdiger, HW, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| German, J | 1 |
| Alhadeff, B | 1 |
| Poot, M | 2 |
| Rüdiger, HW | 2 |
| Hoehn, H | 2 |
| Nicotera, TM | 1 |
3 other studies available for bisbenzimidazole and Bloom Syndrome
| Article | Year |
|---|---|
Analysis of sister-chromatid exchanges.
Topics: Azure Stains; Bisbenzimidazole; Bloom Syndrome; Bromodeoxyuridine; Cytogenetic Analysis; Female; Gen | 2001 |
Detection of free radical-induced DNA damage with bromodeoxyuridine/Hoechst flow cytometry: implications for Bloom's syndrome.
Topics: B-Lymphocytes; Bisbenzimidazole; Bloom Syndrome; Bromodeoxyuridine; Cell Cycle; Cell Transformation, | 1990 |
Cell kinetic evidence suggests elevated oxidative stress in cultured cells of Bloom's syndrome.
Topics: Bisbenzimidazole; Bloom Syndrome; Bromodeoxyuridine; Cell Cycle; Cell Line, Transformed; Cells, Cult | 1989 |