fluorouracil has been researched along with Bloom Syndrome in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Bloom Syndrome: An autosomal recessive disorder characterized by telangiectatic ERYTHEMA of the face, photosensitivity, DWARFISM and other abnormalities, and a predisposition toward developing cancer. The Bloom syndrome gene (BLM) encodes a RecQ-like DNA helicase.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, B | 1 |
| Corry, J | 1 |
| Rischin, D | 1 |
| Leong, T | 1 |
| Peters, LJ | 1 |
| Lönn, U | 1 |
| Lönn, S | 1 |
| Nylen, U | 1 |
| Winblad, G | 1 |
1 review available for fluorouracil and Bloom Syndrome
| Article | Year |
|---|---|
Combined modality treatment for locally advanced squamous-cell carcinoma of the oropharynx in a woman with Bloom's syndrome: a case report and review of the literature.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bloom Syndro | 2001 |
1 other study available for fluorouracil and Bloom Syndrome
| Article | Year |
|---|---|
Increased levels of 5-fluorouracil-induced DNA lesions in Bloom's syndrome.
Topics: Aphidicolin; Bloom Syndrome; Cell Cycle; Cell Line; Diterpenes; DNA; DNA Damage; DNA Glycosylases; D | 1990 |