methyl methanesulfonate has been researched along with Bloom Syndrome in 5 studies
Bloom Syndrome: An autosomal recessive disorder characterized by telangiectatic ERYTHEMA of the face, photosensitivity, DWARFISM and other abnormalities, and a predisposition toward developing cancer. The Bloom syndrome gene (BLM) encodes a RecQ-like DNA helicase.
| Excerpt | Relevance | Reference |
|---|---|---|
| "BLM, the gene mutated in Bloom syndrome, has been cloned previously, and the BLM protein is a member of the RecQ family of DNA helicases." | 1.32 | The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants. ( Campbell, JL; Imamura, O, 2003) |
| "Chromosomal aberrations were also synergistically increased in WRN(-/-)/BLM(-/-) cells when irradiated with UV light in late S to G(2) phases." | 1.31 | Werner and Bloom helicases are involved in DNA repair in a complementary fashion. ( Fujita, K; Furuichi, Y; Imamura, O; Itoh, C; Matsumoto, T; Takeda, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Imamura, O | 2 |
| Campbell, JL | 1 |
| Onoda, F | 2 |
| Seki, M | 3 |
| Miyajima, A | 2 |
| Enomoto, T | 3 |
| Wang, W | 1 |
| Narita, Y | 1 |
| Sonoda, E | 1 |
| Takeda, S | 2 |
| Yamada, K | 1 |
| Masuko, T | 1 |
| Katada, T | 1 |
| Ui, A | 1 |
| Satoh, Y | 1 |
| Fujita, K | 1 |
| Itoh, C | 1 |
| Furuichi, Y | 1 |
| Matsumoto, T | 1 |
5 other studies available for methyl methanesulfonate and Bloom Syndrome
| Article | Year |
|---|---|
The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants.
Topics: Adenosine Triphosphatases; Alkylating Agents; Bloom Syndrome; DNA Helicases; DNA Repair; DNA Replica | 2003 |
Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene.
Topics: Alleles; Bloom Syndrome; DNA Helicases; Dose-Response Relationship, Drug; Genetic Complementation Te | 2000 |
Possible association of BLM in decreasing DNA double strand breaks during DNA replication.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Animals; Base Sequence; Bloom Syndrome; Camptothecin | 2000 |
The N-terminal region of Sgs1, which interacts with Top3, is required for complementation of MMS sensitivity and suppression of hyper-recombination in sgs1 disruptants.
Topics: Amino Acid Sequence; Antineoplastic Agents, Alkylating; Bloom Syndrome; DNA Helicases; DNA Topoisome | 2001 |
Werner and Bloom helicases are involved in DNA repair in a complementary fashion.
Topics: 4-Nitroquinoline-1-oxide; Adenosine Triphosphatases; Amino Acid Sequence; Animals; B-Lymphocytes; Bl | 2002 |