hydroxyurea has been researched along with Bloom Syndrome in 13 studies
Bloom Syndrome: An autosomal recessive disorder characterized by telangiectatic ERYTHEMA of the face, photosensitivity, DWARFISM and other abnormalities, and a predisposition toward developing cancer. The Bloom syndrome gene (BLM) encodes a RecQ-like DNA helicase.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bloom Syndrome is an autosomal recessive cancer-prone disorder caused by mutations in the BLM gene." | 1.35 | BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. ( Ali, AM; Andreassen, PR; Busygina, V; Du, CH; Fan, Q; Meetei, AR; Raynard, S; Singh, TR; Sung, P, 2008) |
| "BLM, the gene mutated in Bloom syndrome, has been cloned previously, and the BLM protein is a member of the RecQ family of DNA helicases." | 1.32 | The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants. ( Campbell, JL; Imamura, O, 2003) |
| "Bloom's syndrome is a rare autosomal recessive genetic disorder characterized by chromosomal aberrations, genetic instability, and cancer predisposition, all of which may be the result of abnormal signal transduction during DNA damage recognition." | 1.32 | Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. ( Celeste, A; Chen, J; Halazonetis, TD; Harris, CC; Linke, SP; Nussenzweig, A; Pedeux, R; Robles, AI; Sengupta, S; Sinogeeva, NI; Ward, IM; Zhang, R, 2004) |
| "Bloom's syndrome (BS) and Werner's syndrome (WS) are genetic disorders in which an increased rate of chromosomal aberration is detected." | 1.30 | Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases. ( Furuichi, Y; Goto, M; Ikeda, H; Kato, J; Shimamoto, A; Yamagata, K, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, TR | 1 |
| Ali, AM | 1 |
| Busygina, V | 1 |
| Raynard, S | 1 |
| Fan, Q | 1 |
| Du, CH | 1 |
| Andreassen, PR | 1 |
| Sung, P | 1 |
| Meetei, AR | 1 |
| Mirzaei, H | 1 |
| Schmidt, KH | 1 |
| Sengupta, S | 2 |
| Linke, SP | 2 |
| Pedeux, R | 2 |
| Yang, Q | 1 |
| Farnsworth, J | 1 |
| Garfield, SH | 1 |
| Valerie, K | 1 |
| Shay, JW | 1 |
| Ellis, NA | 1 |
| Wasylyk, B | 1 |
| Harris, CC | 2 |
| Imamura, O | 1 |
| Campbell, JL | 1 |
| Davies, SL | 1 |
| North, PS | 1 |
| Dart, A | 1 |
| Lakin, ND | 1 |
| Hickson, ID | 1 |
| Robles, AI | 1 |
| Sinogeeva, NI | 1 |
| Zhang, R | 1 |
| Ward, IM | 1 |
| Celeste, A | 1 |
| Nussenzweig, A | 1 |
| Chen, J | 1 |
| Halazonetis, TD | 1 |
| Johnson, RT | 1 |
| Collins, AR | 1 |
| Elliott, GC | 1 |
| Squires, S | 1 |
| Kapp, LN | 1 |
| Painter, RB | 1 |
| Stewart, E | 1 |
| Chapman, CR | 1 |
| Al-Khodairy, F | 1 |
| Carr, AM | 1 |
| Enoch, T | 1 |
| Yamagata, K | 1 |
| Kato, J | 1 |
| Shimamoto, A | 1 |
| Goto, M | 1 |
| Furuichi, Y | 1 |
| Ikeda, H | 1 |
| Onoda, F | 1 |
| Seki, M | 1 |
| Miyajima, A | 1 |
| Enomoto, T | 1 |
| Ababou, M | 1 |
| Dumaire, V | 1 |
| Lécluse, Y | 1 |
| Amor-Guéret, M | 1 |
| Dehazya, P | 1 |
| Sirover, MA | 1 |
1 review available for hydroxyurea and Bloom Syndrome
| Article | Year |
|---|---|
DNA replication fork movement rates in mammalian cells.
Topics: Animals; Autoradiography; Bloom Syndrome; Cell Line; Cell Transformation, Neoplastic; Centrifugation | 1982 |
12 other studies available for hydroxyurea and Bloom Syndrome
| Article | Year |
|---|---|
BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.
Topics: Amino Acid Sequence; Animals; Bloom Syndrome; Bone Neoplasms; Carrier Proteins; Cell Nucleus; Cells, | 2008 |
Non-Bloom syndrome-associated partial and total loss-of-function variants of BLM helicase.
Topics: Alleles; Amino Acid Sequence; Amino Acids; Bloom Syndrome; Diploidy; Heterozygote; Homozygote; Human | 2012 |
BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphatases; Bloom Syndrome; Bromodeoxyuridine; Cell C | 2003 |
The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants.
Topics: Adenosine Triphosphatases; Alkylating Agents; Bloom Syndrome; DNA Helicases; DNA Repair; DNA Replica | 2003 |
Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.
Topics: Adenosine Triphosphatases; Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Bloom Synd | 2004 |
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
Topics: Bloom Syndrome; Blotting, Western; Bromodeoxyuridine; Carrier Proteins; Cell Line; Checkpoint Kinase | 2004 |
Comparative studies of repair using inhibitors.
Topics: Animals; Arvicolinae; Bloom Syndrome; Cell Line; Cells, Cultured; Cytarabine; DNA Repair; Dose-Respo | 1984 |
rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Bloom Syndrome; DNA Helicases; DNA Replication; Exod | 1997 |
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases.
Topics: Base Sequence; Bloom Syndrome; DNA; DNA Helicases; Humans; Hydroxyurea; Mutation; Recombination, Gen | 1998 |
Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene.
Topics: Alleles; Bloom Syndrome; DNA Helicases; Dose-Response Relationship, Drug; Genetic Complementation Te | 2000 |
Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition.
Topics: Adenosine Triphosphatases; Ataxia Telangiectasia Mutated Proteins; Bloom Syndrome; Cell Cycle Protei | 2002 |
Regulation of hypoxanthine DNA glycosylase in normal human and Bloom's syndrome fibroblasts.
Topics: Bloom Syndrome; DNA; DNA Repair; DNA Replication; Enzyme Induction; Fibroblasts; Glycoside Hydrolase | 1986 |