thioguanine-anhydrous and Bloom-Syndrome

thioguanine-anhydrous has been researched along with Bloom-Syndrome* in 1 studies

Other Studies

1 other study(ies) available for thioguanine-anhydrous and Bloom-Syndrome

Article	Year
Bloom's syndrome: evidence for an increased mutation frequency in vivo. Science (New York, N.Y.), 1983, Aug-26, Volume: 221, Issue:4613 The incidence of lymphocytes resistant to the purine analog 6-thioguanine was studied in seven patients with Bloom's syndrome. The mean frequency was 17.3 X 10(-4). The mean incidence in age- and sex-matched controls was 2.1 X 10(-4), so approximately eight times the normal number of 6-thioguanine-resistant lymphocytes were detected in Bloom's syndrome blood. The basis for this increase is unknown, but the inherent genomic instability demonstrated in the form of chromosomal aberrations is one possible explanation. Topics: Bloom Syndrome; DNA Replication; Drug Resistance; Humans; Lymphocytes; Mutation; Thioguanine	1983

Article

Year

Bloom's syndrome: evidence for an increased mutation frequency in vivo.

Science (New York, N.Y.), 1983, Aug-26, Volume: 221, Issue:4613

The incidence of lymphocytes resistant to the purine analog 6-thioguanine was studied in seven patients with Bloom's syndrome. The mean frequency was 17.3 X 10(-4). The mean incidence in age- and sex-matched controls was 2.1 X 10(-4), so approximately eight times the normal number of 6-thioguanine-resistant lymphocytes were detected in Bloom's syndrome blood. The basis for this increase is unknown, but the inherent genomic instability demonstrated in the form of chromosomal aberrations is one possible explanation.

Topics: Bloom Syndrome; DNA Replication; Drug Resistance; Humans; Lymphocytes; Mutation; Thioguanine

1983