alanine has been researched along with Eosinophilia-Myalgia Syndrome in 10 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Eosinophilia-Myalgia Syndrome: A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)
| Excerpt | Relevance | Reference |
|---|---|---|
| "3-(Phenylamino)alanine (PAA), a newly discovered impurity in case-associated L-tryptophan tablets, has been investigated as a possible contributing factor in the etiology of eosinophilia-myalgia syndrome (EMS)." | 7.69 | Accumulation of 3-(phenylamino)alanine, a constituent in L-tryptophan products implicated in eosinophilia-myalgia syndrome, in blood and organs of the Lewis rats. ( Adachi, J; Gomez, M; Smith, CC; Sternberg, EM, 1995) |
| "3-(Phenylamino)alanine (PAA), a contaminant found in L-tryptophan tablets, has been discussed as a possible cause of eosinophilia-myalgia syndrome (EMS)." | 7.69 | Identification of four metabolites of 3-(phenylamino)alanine, a constituent in L-tryptophan products implicated in eosinophilia-myalgia syndrome, in rats. ( Adachi, J; Fujiwara, S; Mio, T; Naito, T; Nishimura, A; Sumino, K; Tatsuno, Y; Ueno, Y, 1994) |
| "Consumption of certain product lots of L-tryptophan (LT) has been reported to be epidemiologically associated with an outbreak of eosinophilia-myalgia syndrome (EMS) in the United States." | 7.69 | Subchronic toxicity of 3-phenylamino alanine, an impurity in L-tryptophan reported to be associated with eosinophilia-myalgia syndrome. ( Hagiwara, Y; Kawase, Y; Sato, F, 1995) |
| "3-(Phenylamino)alanine (PAA), a contaminant found in L-tryptophan tablets, has been discussed as a possible cause of eosinophilia-myalgia syndrome (EMS)." | 3.69 | Identification of four metabolites of 3-(phenylamino)alanine, a constituent in L-tryptophan products implicated in eosinophilia-myalgia syndrome, in rats. ( Adachi, J; Fujiwara, S; Mio, T; Naito, T; Nishimura, A; Sumino, K; Tatsuno, Y; Ueno, Y, 1994) |
| "Consumption of certain product lots of L-tryptophan (LT) has been reported to be epidemiologically associated with an outbreak of eosinophilia-myalgia syndrome (EMS) in the United States." | 3.69 | Subchronic toxicity of 3-phenylamino alanine, an impurity in L-tryptophan reported to be associated with eosinophilia-myalgia syndrome. ( Hagiwara, Y; Kawase, Y; Sato, F, 1995) |
| "An aniline derivative which corresponds to UV-5 in the preceding paper was isolated from the case L-tryptophan sample associated with eosinophilia-myalgia syndrome (EMS)." | 3.68 | 3-anilino-L-alanine, structural determination of UV-5, a contaminant in EMS-associated L-tryptophan samples. ( Goda, Y; Maitani, T; Suzuki, J; Takeda, M; Uchiyama, M; Yoshihira, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (90.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MartÃnez-Cabot, A | 1 |
| Messeguer, A | 1 |
| Adachi, J | 3 |
| Gomez, M | 2 |
| Smith, CC | 2 |
| Sternberg, EM | 2 |
| Mio, T | 1 |
| Ueno, Y | 2 |
| Naito, T | 1 |
| Nishimura, A | 1 |
| Fujiwara, S | 1 |
| Sumino, K | 1 |
| Tatsuno, Y | 2 |
| Philen, RM | 1 |
| Hill, RH | 1 |
| Sato, F | 1 |
| Hagiwara, Y | 1 |
| Kawase, Y | 1 |
| Sidransky, H | 1 |
| Verney, E | 1 |
| Latham, P | 1 |
| Schwartz, A | 1 |
| Steinhart, H | 1 |
| van Wickern, B | 1 |
| Meyer, K | 1 |
| Simat, T | 1 |
| Goda, Y | 1 |
| Suzuki, J | 1 |
| Maitani, T | 1 |
| Yoshihira, K | 1 |
| Takeda, M | 1 |
| Uchiyama, M | 1 |
| Mayeno, AN | 1 |
| Belongia, EA | 1 |
| Lin, F | 1 |
| Lundy, SK | 1 |
| Gleich, GJ | 1 |
1 review available for alanine and Eosinophilia-Myalgia Syndrome
| Article | Year |
|---|---|
Effects of tryptophan related compounds on nuclear regulatory control. Possible role in the eosinophilia-myalgia syndrome.
Topics: Alanine; Animals; Drug Contamination; Eosinophilia-Myalgia Syndrome; Humans; Liver; Nuclear Envelope | 1996 |
9 other studies available for alanine and Eosinophilia-Myalgia Syndrome
| Article | Year |
|---|---|
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome.
Topics: Alanine; Biotransformation; Chromatography, High Pressure Liquid; Disease Outbreaks; Eosinophilia-My | 2007 |
Accumulation of 3-(phenylamino)alanine, a constituent in L-tryptophan products implicated in eosinophilia-myalgia syndrome, in blood and organs of the Lewis rats.
Topics: Alanine; Animals; Chromatography, High Pressure Liquid; Drug Contamination; Drug Residues; Eosinophi | 1995 |
Identification of four metabolites of 3-(phenylamino)alanine, a constituent in L-tryptophan products implicated in eosinophilia-myalgia syndrome, in rats.
Topics: Administration, Oral; Alanine; Animals; Blood-Brain Barrier; Brain; Chromatography, High Pressure Li | 1994 |
3-(Phenylamino)alanine--a link between eosinophilia-myalgia syndrome and toxic oil syndrome?
Topics: Alanine; Brassica; Eosinophilia-Myalgia Syndrome; Fatty Acids, Monounsaturated; Food Contamination; | 1993 |
Subchronic toxicity of 3-phenylamino alanine, an impurity in L-tryptophan reported to be associated with eosinophilia-myalgia syndrome.
Topics: Administration, Oral; Alanine; Animals; Blood Chemical Analysis; Brain; Chromatography, High Pressur | 1995 |
A comparative study of tissue distribution and excretion among three substances implicated in eosinophilia-myalgia syndrome.
Topics: Alanine; Animals; Biotransformation; Brain; Carbolines; Eosinophilia-Myalgia Syndrome; Humans; Kidne | 1996 |
Synthesis and analysis of contaminants in ems-related tryptophan.
Topics: Alanine; Chromatography, High Pressure Liquid; Drug Contamination; Eosinophilia-Myalgia Syndrome; Hu | 1996 |
3-anilino-L-alanine, structural determination of UV-5, a contaminant in EMS-associated L-tryptophan samples.
Topics: Alanine; Chromatography, High Pressure Liquid; Eosinophilia-Myalgia Syndrome; Humans; Magnetic Reson | 1992 |
3-(Phenylamino)alanine, a novel aniline-derived amino acid associated with the eosinophilia-myalgia syndrome: a link to the toxic oil syndrome?
Topics: Alanine; beta-Alanine; Brassica; Chromatography, High Pressure Liquid; Drug Contamination; Eosinophi | 1992 |