mephenytoin has been researched along with Eosinophilia-Myalgia Syndrome in 1 studies
Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
mephenytoin : An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Eosinophilia-Myalgia Syndrome: A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mephenytoin S/R ratios were 0." | 1.29 | Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome. ( Clauw, DJ; Flockhart, DA; Hewett, J; Sale, EB; Woosley, RL, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Flockhart, DA | 1 |
| Clauw, DJ | 1 |
| Sale, EB | 1 |
| Hewett, J | 1 |
| Woosley, RL | 1 |
1 other study available for mephenytoin and Eosinophilia-Myalgia Syndrome
| Article | Year |
|---|---|
Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome.
Topics: Alleles; Arylamine N-Acetyltransferase; Case-Control Studies; Dapsone; Debrisoquin; Eosinophilia-Mya | 1994 |