fluorouracil has been researched along with Adenoma, alpha-Cell in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malignant glucagonoma is an exceptional pancreatic endocrine tumour, with frequent dermatologic symptoms, diabetes and degradation of the general health status." | 1.36 | [Dramatic efficacy of chemotherapy with 5-fluorouracil and dacarbazine in a patient with metastatic glucagonoma and cardiac insufficiency]. ( de Mestier, L; Dove, P; Hammel, P; Hentic, O; Lévy, P; Ruszniewski, P, 2010) |
| "The development of diabetic ketoacidosis is an unusual complication of a glucagon-secreting pancreatic islet cell neoplasm, with only four reported cases in the literature." | 1.29 | Case report: diabetic ketoacidosis in a patient with glucagonoma. ( Anthony, LB; May, ME; Sharp, SC, 1995) |
| "Four patients with metastatic glucagonoma are described." | 1.26 | Glucagonoma and its angiographic diagnosis. ( Keller, FS; Lieberman, DA; Rösch, J; Wawrukiewicz, AS, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Mestier, L | 1 |
| Hammel, P | 1 |
| Hentic, O | 1 |
| Dove, P | 1 |
| Lévy, P | 1 |
| Ruszniewski, P | 1 |
| Wawrukiewicz, AS | 1 |
| Rösch, J | 1 |
| Keller, FS | 1 |
| Lieberman, DA | 1 |
| Hallengren, B | 1 |
| Dymling, JF | 1 |
| Manhem, P | 1 |
| Tennvall, L | 1 |
| Tibblin, S | 1 |
| Anthony, LB | 1 |
| Sharp, SC | 1 |
| May, ME | 1 |
| Brentjens, R | 1 |
| Saltz, L | 1 |
| Jones, DV | 1 |
| Samaan, NA | 1 |
| Sellin, RV | 1 |
| Ajani, JA | 1 |
| Lee, SM | 1 |
| Forbes, A | 1 |
| Williams, R | 1 |
| Altimari, AF | 1 |
| Bhoopalam, N | 1 |
| O'Dorsio, T | 1 |
| Lange, CL | 1 |
| Sandberg, L | 1 |
| Prinz, RA | 1 |
1 review available for fluorouracil and Adenoma, alpha-Cell
| Article | Year |
|---|---|
Islet cell tumors of the pancreas: the medical oncologist's perspective.
Topics: Adenoma, Islet Cell; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Ag | 2001 |
7 other studies available for fluorouracil and Adenoma, alpha-Cell
| Article | Year |
|---|---|
[Dramatic efficacy of chemotherapy with 5-fluorouracil and dacarbazine in a patient with metastatic glucagonoma and cardiac insufficiency].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cardiomyopathy, Dilated; Dacarbazine; Female; | 2010 |
Glucagonoma and its angiographic diagnosis.
Topics: Adenoma, Islet Cell; Adult; Aged; Angiography; Antineoplastic Agents; Dacarbazine; Drug Therapy, Com | 1982 |
Unsuccessful DTIC treatment of a patient with glucagonoma syndrome.
Topics: Adenoma, Islet Cell; Dacarbazine; Drug Therapy, Combination; Fluorouracil; Glucagonoma; Humans; Live | 1983 |
Case report: diabetic ketoacidosis in a patient with glucagonoma.
Topics: Diabetic Ketoacidosis; Female; Fluid Therapy; Fluorouracil; Glucagonoma; Humans; Insulin; Middle Age | 1995 |
Metastatic glucagonoma: clinical response to a combination of 5-fluorouracil and alpha-interferon.
Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Glucagonoma; Humans; Interferon alpha- | 1992 |
Metastatic islet cell tumour with clinical manifestations of insulin and glucagon excess: successful treatment by hepatic artery embolization and chemotherapy.
Topics: Adenoma, Islet Cell; Combined Modality Therapy; Embolization, Therapeutic; Female; Fluorouracil; Glu | 1988 |
Use of a somatostatin analog (SMS 201-995) in the glucagonoma syndrome.
Topics: Adenoma, Islet Cell; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dacarbaz | 1986 |