amidantel profile

Amidantel is an anti-parasitic drug that has been studied for its potential to treat various parasitic infections, particularly in animals. Its synthesis involves several steps, including the reaction of 2-amino-4,5-dimethylthiazole with 1,3-dichloro-2-propanol. Amidantel is known to exhibit anthelmintic activity, meaning it can kill or paralyze parasitic worms. Research on amidantel focuses on its efficacy against various parasitic infections, its potential for development as a veterinary drug, and its safety profile. However, there are limited clinical trials on humans, and its use in humans is not widely established.'

amidantel: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	39521
CHEMBL ID	2105966
CHEMBL ID	4784193
SCHEMBL ID	381858
MeSH ID	M0071369

Synonym
amidantel
n-[4-[1-(dimethylamino)ethylideneamino]phenyl]-2-methoxyacetamide
CHEMBL2105966
c67is11n0o ,
bay d 8815 [hydrochloride]
amidantelum
amidantel [inn:ban]
amidantelum [inn-latin]
unii-c67is11n0o
49745-00-8
acetamide, n-(4-((1-(dimethylamino)ethylidene)amino)phenyl)-2-methoxy-
4'-((1-(dimethylamino)ethylidene)amino)-2-methoxyacetanilide
bay d 8815 free base
bay-d-8815 free base
bay-d 8815 free base
amidantel [inn]
SCHEMBL381858
DTXSID70198009
Q27275235
n-(4-((1-(dimethylamino)ethylidene)amino)phenyl)-2-methoxyacetamide
49745-00-8 (free base)
amidantel free base
n-(4-{[1-(dimethylamino)ethylidene]amino}phenyl)-2-methoxyacetamide
DTXSID80866141
CHEMBL4784193
AKOS040750417

Excerpt	Reference	Relevance
"Amidantel is a new anthelmintic from a new chemical class with an interesting anthelmintic spectrum. "	( The efficacy of amidantel, a new anthelmintic, on hookworms and ascarids in dogs. Thomas, H, 1979)	2.05

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (45.45)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (54.55)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (9.09%)	5.53%
Reviews	1 (9.09%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (81.82%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
hycanthone Hycanthone: Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.. hycanthone : A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.	6.97	1	0	thioxanthenes	mutagen; schistosomicide drug
trichlorfon Trichlorfon: An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed). trichlorfon : A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.	1.96	1	0	organic phosphonate; organochlorine compound; phosphonic ester	agrochemical; anthelminthic drug; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; insecticide
levamisole Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6). levamisole : A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.	6.97	1	0	6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole	antinematodal drug; antirheumatic drug; EC 3.1.3.1 (alkaline phosphatase) inhibitor; immunological adjuvant; immunomodulator
pyrantel Pyrantel: A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920). pyrantel : A carboxamidine that is 1,4,5,6-tetrahydropyrimidine that is substituted at position 1 by a methyl group and at position 2 by an (E)-2-(2-thienyl)vinyl group. It is used, particularly as the embonate [4,4'-methylenebis(3-hydroxy-2-naphthoate)] salt, as an anthelmintic that is effective against intestinal nematodes including threadworms, roundworms and hookworms, and is included in the WHO 'Model List of Essential Medicines'.	6.97	1	0	1,4,5,6-tetrahydropyrimidines; carboxamidine; thiophenes	antinematodal drug
tribendimidine tribendimidine: structure given in first source	10.8	6	1
pyrantel pamoate Pyrantel Pamoate: Broad spectrum antinematodal anthelmintic used also in veterinary medicine.	2.42	2	0	organic molecular entity
oxantel pamoate [no description available]	2.21	1	0	naphthoic acid
morantel Morantel: Antinematodal agent used mainly for livestock.	6.97	1	0
dextrothyroxine [no description available]	2.21	1	0

Condition	Relationship Strength	Studies	Trials
Helminthiasis, Animal Infestation of animals with parasitic worms of the helminth class. The infestation may be experimental or veterinary.	2.21	1	0
Opisthorchis felineus Infection [description not available]	3.59	1	1
Opisthorchiasis Infection with flukes of the genus Opisthorchis.	3.59	1	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.49	2	0
Trichocephaliasis [description not available]	2.1	1	0
Trichuriasis Infection with nematodes of the genus TRICHURIS, formerly called Trichocephalus.	2.1	1	0
Hymenolepiasis Infection with tapeworms of the genus Hymenolepis.	2.07	1	0
Infections, Nematomorpha [description not available]	3.31	2	0
Helminthiasis Infestation with parasitic worms of the helminth class.	3.31	2	0
Ancylostomiasis Infection of humans or animals with hookworms of the genus ANCYLOSTOMA. Characteristics include anemia, dyspepsia, eosinophilia, and abdominal swelling.	2.36	2	0
Bunostomiasis [description not available]	1.95	1	0
Infections, Nematode [description not available]	2.36	2	0
Hookworm Infections Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.	1.95	1	0
Toxocariasis Infection by round worms of the genus TOXOCARA, usually found in wild and domesticated cats and dogs and foxes, except for the larvae, which may produce visceral and ocular larva migrans in man.	1.95	1	0
Necatoriasis Infection of humans or animals with hookworms of the genus NECATOR. The resulting anemia from this condition is less severe than that from ANCYLOSTOMIASIS.	1.97	1	0
Abnormalities, Drug-Induced Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.	1.96	1	0

amidantel

Description

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Synonyms (26)

Research Excerpts

Overview

Research

Studies (11)

Market Indicators

Research Demand Index: 16.94

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