piperazine adipate profile

Piperazine adipate is a salt formed from the reaction of piperazine with adipic acid. It has been investigated for its potential therapeutic effects in various conditions, including epilepsy, Parkinson's disease, and cancer. Studies have shown that piperazine adipate can exhibit anticonvulsant activity and may possess neuroprotective properties. The compound's mechanism of action involves modulating neurotransmitter systems and influencing calcium channel activity. However, research on piperazine adipate is still ongoing, and further investigations are needed to fully understand its pharmacological properties and potential clinical applications.'

piperazine adipate : A piperazinium salt obtained by combining equimolar amounts of piperazine and adipic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	8905
CHEMBL ID	3276110
CHEBI ID	133924
SCHEMBL ID	1642955
MeSH ID	M0047007

Synonym
AKOS015839637
adipic acid; piperazine
piperazine, monoadipate
einecs 205-569-0
oxyzin (van)
hexanedioic acid, compound with piperazine (1:1)
vermicompren (tabl.)
ai3-20824
nsc 74383
oxyzin (tabl.)
142-88-1
vermilass
wln: t6n dntj & qv4vq
oxypaat
divermex
pipadox
nsc74383
adiprazine
arduvermin
nsc-74383
dietelmin
piperazine adipate
adiprazina
oxurasin
piperaskat
piperascat
nometan
helmirazin
vermicompren
camin ap (tn)
piperazine adipate (jp17/usp)
D02145
hexanedioic acid--piperazine (1/1)
CHEBI:133924
piperazinium adipate
piperazinium hexanedioate
piperazine-1,4-diium hexanedioate
hexanedioic acid - piperazine (1:1)
hexanedioic acid; piperazine
P0448
ec 205-569-0
piperazine adipate (1:1)
piperazine adipate [usp:jan]
unii-v7p5p122lb
v7p5p122lb ,
S4443
piperazine adipate [mart.]
piperazine, hexanedioate (1:1)
piperazine adipate [mi]
piperazine adipate [usp monograph]
piperazine adipate [usp-rs]
piperazine, adipate (1:1)
piperazine adipate [green book]
piperazini adipas [who-ip latin]
piperazine adipate [jan]
piperazine adipate [who-ip]
piperazine adipate [ep monograph]
piperazine adipate [who-dd]
CHEMBL3276110
SCHEMBL1642955
DTXSID2059724
CS-7763
W-109511
piperazine adipate, united states pharmacopeia (usp) reference standard
piperazine adipate, european pharmacopoeia (ep) reference standard
piperazine adipate; piperazine hexanedioate
HY-B2186
FT-0751551
142-88-1 (adipate)
mfcd00050650
hexanedioic acid;piperazine
vermicompren;adiprazine
BCP32242
E78817
Q27291639
piperazine hexanedioic acid
piperazine adipate 100 microg/ml in water
BS-42127
piperazinehexanedioicacid
EN300-82962

Excerpt	Relevance	Reference
" canis eggs shed into the environment, but that multiple dosing remains essential for this purpose."	( Studies on the control of Toxocara canis in breeding kennels. Dick, IG; Fisher, MA; Hutchinson, MJ; Jacobs, DE, 1994)	0.29

Role	Description
anthelminthic drug	Substance intended to kill parasitic worms (helminths).
antinematodal drug	A substance used in the treatment or control of nematode infestations.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
piperazinium salt
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID1150404	Anthelmintic activity against Syphacia obvelata infected in mouse assessed as reduction in worm burden at 300 mg/kg, po bid for 5 days	1976	Journal of medicinal chemistry, Feb, Volume: 19, Issue:2	Anthelmintic 1-cinnamamido-2,4-imidazolidinediones.
AID1150406	Anthelmintic activity against Syphacia obvelata infected in mouse assessed as reduction in worm burden at 50 mg/kg, po bid for 5 days	1976	Journal of medicinal chemistry, Feb, Volume: 19, Issue:2	Anthelmintic 1-cinnamamido-2,4-imidazolidinediones.
AID1150405	Anthelmintic activity against Syphacia obvelata infected in mouse assessed as reduction in worm burden at 100 mg/kg, po bid for 5 days	1976	Journal of medicinal chemistry, Feb, Volume: 19, Issue:2	Anthelmintic 1-cinnamamido-2,4-imidazolidinediones.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	25 (86.21)	18.7374
1990's	4 (13.79)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (2.56%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (2.56%)	4.05%
Observational	0 (0.00%)	0.25%
Other	37 (94.87%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	1.97	1	0	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
pyridoxine 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source. vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).	1.94	1	0	hydroxymethylpyridine; methylpyridines; monohydroxypyridine; vitamin B6	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
fenbendazole Fenbendazole: Antinematodal benzimidazole used in veterinary medicine.. fenbendazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted at positons 2 and 5 by (methoxycarbonyl)amino and phenylsulfanediyl groups, respectively. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.	3.37	1	1	aryl sulfide; benzimidazoles; carbamate ester	antinematodal drug
piperazine [no description available]	1.94	1	0	azacycloalkane; piperazines; saturated organic heteromonocyclic parent	anthelminthic drug
promethazine Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.. promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.	1.95	1	0	phenothiazines; tertiary amine	anti-allergic agent; anticoronaviral agent; antiemetic; antipruritic drug; H1-receptor antagonist; local anaesthetic; sedative
dithiazanine Dithiazanine: 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium. A benzothiazole that was formerly used as an antinematodal agent and is currently used as a fluorescent dye.. dithiazanine : A cationic C3-cyanine dye with 3-ethylbenzothiazol-2-yl groups at both ends.	6.93	1	0	benzothiazoles; benzothiazolium ion	anthelminthic drug; fluorochrome
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	6.93	1	0	copper group element atom; elemental silver	Escherichia coli metabolite
parbendazole parbendazole: anthelmintic used against a variety of gastrointestinal parasites; minor descriptor (75-86); on-line & INDEX MEDICUS search BENZIMIDAZOLES; RN given refers to parent cpd	6.97	1	0	benzimidazoles; carbamate ester
tetrachloroethylene Tetrachloroethylene: A chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.	1.93	1	0	chlorocarbon; chloroethenes	nephrotoxic agent
cortisone [no description available]	6.93	1	0	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	human metabolite; mouse metabolite
glycogen glycogen : A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.	1.97	1	0
pyrantel Pyrantel: A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920). pyrantel : A carboxamidine that is 1,4,5,6-tetrahydropyrimidine that is substituted at position 1 by a methyl group and at position 2 by an (E)-2-(2-thienyl)vinyl group. It is used, particularly as the embonate [4,4'-methylenebis(3-hydroxy-2-naphthoate)] salt, as an anthelmintic that is effective against intestinal nematodes including threadworms, roundworms and hookworms, and is included in the WHO 'Model List of Essential Medicines'.	1.97	1	0	1,4,5,6-tetrahydropyrimidines; carboxamidine; thiophenes	antinematodal drug
piperidines Piperidines: A family of hexahydropyridines.	2.34	2	0

Condition	Relationship Strength	Studies	Trials
Aspiculariasis [description not available]	3.55	9	0
Infections, Nematomorpha [description not available]	2.34	2	0
Helminthiasis Infestation with parasitic worms of the helminth class.	2.34	2	0
Ascariasis Infection by nematodes of the genus ASCARIS. Ingestion of infective eggs causes diarrhea and pneumonitis. Its distribution is more prevalent in areas of poor sanitation and where human feces are used for fertilizer.	3.63	10	0
Ancylostomiasis Infection of humans or animals with hookworms of the genus ANCYLOSTOMA. Characteristics include anemia, dyspepsia, eosinophilia, and abdominal swelling.	2.33	2	0
Bunostomiasis [description not available]	2.33	2	0
Hookworm Infections Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.	2.33	2	0
Infections, Nematode [description not available]	1.93	1	0
Trichostrongylosis Infestation with nematode worms of the genus TRICHOSTRONGYLUS. Man and animals become infected by swallowing larvae, usually with contaminated food or drink, although the larvae may penetrate human skin.	1.93	1	0
Animal Diseases Diseases that occur in VERTEBRATE animals.	1.93	1	0
Disease A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.	1.93	1	0
Parasite Infections [description not available]	1.93	1	0
Encephalopathy, Toxic [description not available]	1.94	1	0
Focal Neurologic Deficits [description not available]	1.94	1	0
Human Trichinellosis [description not available]	1.93	1	0
Trichinellosis An infection with TRICHINELLA. It is caused by eating raw or undercooked meat that is infected with larvae of nematode worms TRICHINELLA genus. All members of the TRICHINELLA genus can infect human in addition to TRICHINELLA SPIRALIS, the traditional etiological agent. It is distributed throughout much of the world and is re-emerging in some parts as a public health hazard and a food safety problem.	1.93	1	0
Poultry Diseases Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	1.98	1	0
Ascaridiasis Infection with nematodes of the genus ASCARIDIA. This condition usually occurs in fowl, often manifesting diarrhea.	1.98	1	0
Canine Diseases [description not available]	3.37	1	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	3.37	1	1
Toxocariasis Infection by round worms of the genus TOXOCARA, usually found in wild and domesticated cats and dogs and foxes, except for the larvae, which may produce visceral and ocular larva migrans in man.	3.37	1	1
Tuberculosis, Renal Infection of the KIDNEY with species of MYCOBACTERIUM.	1.97	1	0
Complications, Infectious Pregnancy [description not available]	1.97	1	0
Abnormalities, Drug-Induced Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.	1.97	1	0
Congenital Foot Deformities [description not available]	1.97	1	0
Congenital Hand Deformities [description not available]	1.97	1	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.97	1	0
Chronic Illness [description not available]	1.96	1	0
Recrudescence [description not available]	1.96	1	0
Boils [description not available]	1.96	1	0
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	1.96	1	0

piperazine adipate

Description

Cross-References

Synonyms (80)

Research Excerpts

Dosage Studied

Roles (2)

Drug Classes (1)

Bioassays (3)

Research

Studies (29)

Market Indicators

Research Demand Index: 33.59

Study Types