| ID Source | ID |
|---|---|
| PubMed CID | 6441236 |
| CHEMBL ID | 151870 |
| SCHEMBL ID | 678719 |
| MeSH ID | M0272543 |
| Synonym |
|---|
| agn 190121 |
| benzoic acid, 4-(4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-1-ynyl)-, (e)- |
| (e)-4-(4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-1-ynyl)benzoic acid |
| CHEMBL151870 , |
| 4-[(e)-4-(2,6,6-trimethyl-cyclohex-1-enyl)-but-3-en-1-ynyl]-benzoic acid |
| bdbm50097824 |
| 4-[(e)-4-(2,6,6-trimethylcyclohexen-1-yl)but-3-en-1-ynyl]benzoic acid |
| 132032-67-8 |
| SCHEMBL678719 |
| agn-190121 |
| PD160878 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| Retinoic acid receptor alpha | Homo sapiens (human) | EC50 | 0.4350 | AID197921 |
| Retinoic acid receptor alpha | Homo sapiens (human) | Kd | 0.1350 | AID198050 |
| Retinoic acid receptor beta | Homo sapiens (human) | EC50 | 0.0070 | AID198377 |
| Retinoic acid receptor beta | Homo sapiens (human) | Kd | 0.0200 | AID198539 |
| Retinoic acid receptor gamma | Homo sapiens (human) | EC50 | 0.0100 | AID198898 |
| Retinoic acid receptor gamma | Homo sapiens (human) | Kd | 0.1900 | AID199050 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID198539 | Binding affinity towards retinoic acid receptor beta was determined using [3H]ATRA (5 nM) as radioligand | 2001 | Bioorganic & medicinal chemistry letters, Mar-26, Volume: 11, Issue:6 ISSN: 0960-894X | Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity. |
| AID198898 | Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor gamma | 2001 | Bioorganic & medicinal chemistry letters, Mar-26, Volume: 11, Issue:6 ISSN: 0960-894X | Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity. |
| AID198377 | Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor beta | 2001 | Bioorganic & medicinal chemistry letters, Mar-26, Volume: 11, Issue:6 ISSN: 0960-894X | Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity. |
| AID199050 | Binding affinity towards retinoic acid receptor gamma was determined using [3H]ATRA (5 nM) as radioligand | 2001 | Bioorganic & medicinal chemistry letters, Mar-26, Volume: 11, Issue:6 ISSN: 0960-894X | Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity. |
| AID197921 | Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor alpha | 2001 | Bioorganic & medicinal chemistry letters, Mar-26, Volume: 11, Issue:6 ISSN: 0960-894X | Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity. |
| AID198050 | Binding affinity towards retinoic acid receptor alpha was determined using [3H]ATRA (5 nM) as radioligand | 2001 | Bioorganic & medicinal chemistry letters, Mar-26, Volume: 11, Issue:6 ISSN: 0960-894X | Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| agn 193109 | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |||
| tretinoin | retinoic acid; vitamin A | anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dermatitis, Irritant | 0 | 2001 | 2001 | 23.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 | |
| Disease Models, Animal | 0 | 1996 | 2001 | 25.5 | high | 0 | 0 | 1 | 1 | 0 | 0 | |
| Hyperplasia | 0 | 1997 | 1997 | 27.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 | |
| Hypertriglyceridemia | 0 | 2001 | 2001 | 23.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 | |
| Pregnancy | 0 | 1998 | 1998 | 26.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| Article | Year |
|---|---|
| Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents. Biochemical pharmacology, , Dec-01, Volume: 62, Issue:11 | 2001 |