ipi 493 profile

17-aminogeldanamycin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	9893658
SCHEMBL ID	8250568
SCHEMBL ID	16226317
MeSH ID	M0571268

Synonym
17-aminodemethoxygeldanamycin
64202-81-9
17-amino-17-demethoxygeldanamycin
geldanamycin, 17-amino-17-demethoxy-
nsc-255109
ipi-493
ipi 493
17-aminogeldanamycin
slq1ajg3vb ,
nsc 255109
2-azabicyclo(16.3.1)docosa-4,6,10,18,21-pentaene-3,20,22-trione, 19-amino-9-((aminocarbonyl)oxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-, (8r,9r,12r,13s,14r,16r)-
unii-slq1ajg3vb
17-amino geldanamycin
17aag metabolite m8
ipi 493 [who-dd]
SCHEMBL8250568
SCHEMBL16226317
DB13023
XYFFWTYOFPSZRM-TWNAANEASA-N
[(4e,6z,8s,9s,10e,12s,13r,14s,16r)-19-amino-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
Q27289269

Excerpt	Relevance	Reference
" Specifically, dosed intraperitoneally at 100 mg/kg, 17-(allylamino)-17-demethoxygeldanamycin and other 17-amino analogs were effective at reducing p185 phosphotyrosine in subcutaneous flank FRE/erbB-2 tumors."	( Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives. Barbacci, EG; Cooper, BA; Corman, ML; Dee, MF; DiOrio, CI; Doty, JL; Gallaschun, RJ; Moyer, JD; Muzzi, ML; Schnur, RC, 1995)	0.29

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Heat shock protein HSP 90-beta	Homo sapiens (human)	IC50 (µMol)	0.0095	0.0010	0.6836	10.0000	AID465281; AID465283
Heat shock protein HSP 90-beta	Homo sapiens (human)	Ki	0.0120	0.0001	0.0373	0.5300	AID465289; AID465293
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
Heat shock protein HSP 90-alpha	Homo sapiens (human)	EC50 (µMol)	0.0236	0.0040	0.1331	1.2000	AID266546; AID266550; AID266551; AID266552; AID266553
Heat shock protein HSP 90-alpha	Homo sapiens (human)	Kd	0.1000	0.0003	0.9488	9.8000	AID254267
Heat shock protein HSP 90-beta	Homo sapiens (human)	EC50 (µMol)	0.0236	0.0040	0.2385	1.7000	AID266546; AID266550; AID266551; AID266552; AID266553
Heat shock protein HSP 90-beta	Homo sapiens (human)	Kd	0.1000	0.0003	1.3330	9.8000	AID350568
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7367	7.0000	AID266551
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0001	1.4693	7.0000	AID266551
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
Endoplasmin	Canis lupus familiaris (dog)	EC50 (µMol)	0.0480	0.0480	0.0790	0.1240	AID266547
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	2.1499	10.0000	AID266551
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7367	7.0000	AID266551
GABA theta subunit	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0530	0.0190	1.7054	7.0000	AID266551
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
telomere maintenance via telomerase	Heat shock protein HSP 90-alpha	Homo sapiens (human)
neuron migration	Heat shock protein HSP 90-alpha	Homo sapiens (human)
positive regulation of protein phosphorylation	Heat shock protein HSP 90-alpha	Homo sapiens (human)
activation of innate immune response	Heat shock protein HSP 90-alpha	Homo sapiens (human)
positive regulation of defense response to virus by host	Heat shock protein HSP 90-alpha	Homo sapiens (human)
skeletal muscle contraction	Heat shock protein HSP 90-alpha	Homo sapiens (human)
mitochondrial transport	Heat shock protein HSP 90-alpha	Homo sapiens (human)
response to unfolded protein	Heat shock protein HSP 90-alpha	Homo sapiens (human)
response to heat	Heat shock protein HSP 90-alpha	Homo sapiens (human)
response to cold	Heat shock protein HSP 90-alpha	Homo sapiens (human)
response to xenobiotic stimulus	Heat shock protein HSP 90-alpha	Homo sapiens (human)
response to salt stress	Heat shock protein HSP 90-alpha	Homo sapiens (human)
positive regulation of lamellipodium assembly	Heat shock protein HSP 90-alpha	Homo sapiens (human)
cardiac muscle cell apoptotic process	Heat shock protein HSP 90-alpha	Homo sapiens (human)
regulation of protein ubiquitination	Heat shock protein HSP 90-alpha	Homo sapiens (human)
positive regulation of protein polymerization	Heat shock protein HSP 90-alpha	Homo sapiens (human)
positive regulation of interferon-beta production	Heat shock protein HSP 90-alpha	Homo sapiens (human)
regulation of protein localization	Heat shock protein HSP 90-alpha	Homo sapiens (human)
protein refolding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
response to cocaine	Heat shock protein HSP 90-alpha	Homo sapiens (human)
positive regulation of protein import into nucleus	Heat shock protein HSP 90-alpha	Homo sapiens (human)
regulation of apoptotic process	Heat shock protein HSP 90-alpha	Homo sapiens (human)
regulation of protein-containing complex assembly	Heat shock protein HSP 90-alpha	Homo sapiens (human)
protein unfolding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
response to estrogen	Heat shock protein HSP 90-alpha	Homo sapiens (human)
protein insertion into mitochondrial outer membrane	Heat shock protein HSP 90-alpha	Homo sapiens (human)
positive regulation of nitric oxide biosynthetic process	Heat shock protein HSP 90-alpha	Homo sapiens (human)
positive regulation of protein catabolic process	Heat shock protein HSP 90-alpha	Homo sapiens (human)
positive regulation of cell size	Heat shock protein HSP 90-alpha	Homo sapiens (human)
response to antibiotic	Heat shock protein HSP 90-alpha	Homo sapiens (human)
protein stabilization	Heat shock protein HSP 90-alpha	Homo sapiens (human)
chaperone-mediated protein complex assembly	Heat shock protein HSP 90-alpha	Homo sapiens (human)
positive regulation of cardiac muscle contraction	Heat shock protein HSP 90-alpha	Homo sapiens (human)
chaperone-mediated autophagy	Heat shock protein HSP 90-alpha	Homo sapiens (human)
cellular response to virus	Heat shock protein HSP 90-alpha	Homo sapiens (human)
regulation of postsynaptic membrane neurotransmitter receptor levels	Heat shock protein HSP 90-alpha	Homo sapiens (human)
positive regulation of tau-protein kinase activity	Heat shock protein HSP 90-alpha	Homo sapiens (human)
telomerase holoenzyme complex assembly	Heat shock protein HSP 90-alpha	Homo sapiens (human)
cellular response to heat	Heat shock protein HSP 90-alpha	Homo sapiens (human)
protein folding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
telomere maintenance via telomerase	Heat shock protein HSP 90-beta	Homo sapiens (human)
placenta development	Heat shock protein HSP 90-beta	Homo sapiens (human)
response to unfolded protein	Heat shock protein HSP 90-beta	Homo sapiens (human)
virion attachment to host cell	Heat shock protein HSP 90-beta	Homo sapiens (human)
positive regulation of transforming growth factor beta receptor signaling pathway	Heat shock protein HSP 90-beta	Homo sapiens (human)
regulation of protein ubiquitination	Heat shock protein HSP 90-beta	Homo sapiens (human)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Heat shock protein HSP 90-beta	Homo sapiens (human)
positive regulation of phosphoprotein phosphatase activity	Heat shock protein HSP 90-beta	Homo sapiens (human)
regulation of protein localization	Heat shock protein HSP 90-beta	Homo sapiens (human)
negative regulation of apoptotic process	Heat shock protein HSP 90-beta	Homo sapiens (human)
positive regulation of nitric oxide biosynthetic process	Heat shock protein HSP 90-beta	Homo sapiens (human)
positive regulation of cell differentiation	Heat shock protein HSP 90-beta	Homo sapiens (human)
chaperone-mediated protein complex assembly	Heat shock protein HSP 90-beta	Homo sapiens (human)
regulation of cell cycle	Heat shock protein HSP 90-beta	Homo sapiens (human)
chaperone-mediated protein folding	Heat shock protein HSP 90-beta	Homo sapiens (human)
cellular response to interleukin-4	Heat shock protein HSP 90-beta	Homo sapiens (human)
supramolecular fiber organization	Heat shock protein HSP 90-beta	Homo sapiens (human)
negative regulation of proteasomal protein catabolic process	Heat shock protein HSP 90-beta	Homo sapiens (human)
telomerase holoenzyme complex assembly	Heat shock protein HSP 90-beta	Homo sapiens (human)
positive regulation of protein localization to cell surface	Heat shock protein HSP 90-beta	Homo sapiens (human)
cellular response to heat	Heat shock protein HSP 90-beta	Homo sapiens (human)
protein folding	Heat shock protein HSP 90-beta	Homo sapiens (human)
protein stabilization	Heat shock protein HSP 90-beta	Homo sapiens (human)
ERAD pathway	Endoplasmin	Canis lupus familiaris (dog)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
UTP binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
CTP binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
RNA binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
mRNA binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
protein binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
ATP binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
GTP binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
ATP hydrolysis activity	Heat shock protein HSP 90-alpha	Homo sapiens (human)
sulfonylurea receptor binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
protein phosphatase binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
MHC class II protein complex binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
nitric-oxide synthase regulator activity	Heat shock protein HSP 90-alpha	Homo sapiens (human)
TPR domain binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
ubiquitin protein ligase binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
dATP binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
identical protein binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
protein homodimerization activity	Heat shock protein HSP 90-alpha	Homo sapiens (human)
histone deacetylase binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
transmembrane transporter binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
tau protein binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
GTPase binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
Rho GDP-dissociation inhibitor binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
DNA polymerase binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
scaffold protein binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
disordered domain specific binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
ATP-dependent protein folding chaperone	Heat shock protein HSP 90-alpha	Homo sapiens (human)
protein tyrosine kinase binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
unfolded protein binding	Heat shock protein HSP 90-alpha	Homo sapiens (human)
RNA binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
double-stranded RNA binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
protein binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
ATP binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
ATP hydrolysis activity	Heat shock protein HSP 90-beta	Homo sapiens (human)
protein kinase regulator activity	Heat shock protein HSP 90-beta	Homo sapiens (human)
kinase binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
protein kinase binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
MHC class II protein complex binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
nitric-oxide synthase regulator activity	Heat shock protein HSP 90-beta	Homo sapiens (human)
TPR domain binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
heat shock protein binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
ubiquitin protein ligase binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
peptide binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
identical protein binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
protein homodimerization activity	Heat shock protein HSP 90-beta	Homo sapiens (human)
histone deacetylase binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
ATP-dependent protein binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
protein folding chaperone	Heat shock protein HSP 90-beta	Homo sapiens (human)
cadherin binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
protein dimerization activity	Heat shock protein HSP 90-beta	Homo sapiens (human)
tau protein binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
DNA polymerase binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
disordered domain specific binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
ATP-dependent protein folding chaperone	Heat shock protein HSP 90-beta	Homo sapiens (human)
receptor ligand inhibitor activity	Heat shock protein HSP 90-beta	Homo sapiens (human)
histone methyltransferase binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
unfolded protein binding	Heat shock protein HSP 90-beta	Homo sapiens (human)
ATP binding	Endoplasmin	Canis lupus familiaris (dog)
ATP hydrolysis activity	Endoplasmin	Canis lupus familiaris (dog)
ATP-dependent protein folding chaperone	Endoplasmin	Canis lupus familiaris (dog)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular region	Heat shock protein HSP 90-alpha	Homo sapiens (human)
nucleus	Heat shock protein HSP 90-alpha	Homo sapiens (human)
nucleoplasm	Heat shock protein HSP 90-alpha	Homo sapiens (human)
cytoplasm	Heat shock protein HSP 90-alpha	Homo sapiens (human)
mitochondrion	Heat shock protein HSP 90-alpha	Homo sapiens (human)
cytosol	Heat shock protein HSP 90-alpha	Homo sapiens (human)
plasma membrane	Heat shock protein HSP 90-alpha	Homo sapiens (human)
cell surface	Heat shock protein HSP 90-alpha	Homo sapiens (human)
membrane	Heat shock protein HSP 90-alpha	Homo sapiens (human)
basolateral plasma membrane	Heat shock protein HSP 90-alpha	Homo sapiens (human)
apical plasma membrane	Heat shock protein HSP 90-alpha	Homo sapiens (human)
brush border membrane	Heat shock protein HSP 90-alpha	Homo sapiens (human)
secretory granule lumen	Heat shock protein HSP 90-alpha	Homo sapiens (human)
melanosome	Heat shock protein HSP 90-alpha	Homo sapiens (human)
neuronal cell body	Heat shock protein HSP 90-alpha	Homo sapiens (human)
lysosomal lumen	Heat shock protein HSP 90-alpha	Homo sapiens (human)
dendritic growth cone	Heat shock protein HSP 90-alpha	Homo sapiens (human)
axonal growth cone	Heat shock protein HSP 90-alpha	Homo sapiens (human)
perinuclear region of cytoplasm	Heat shock protein HSP 90-alpha	Homo sapiens (human)
collagen-containing extracellular matrix	Heat shock protein HSP 90-alpha	Homo sapiens (human)
extracellular exosome	Heat shock protein HSP 90-alpha	Homo sapiens (human)
endocytic vesicle lumen	Heat shock protein HSP 90-alpha	Homo sapiens (human)
sperm mitochondrial sheath	Heat shock protein HSP 90-alpha	Homo sapiens (human)
sperm plasma membrane	Heat shock protein HSP 90-alpha	Homo sapiens (human)
ficolin-1-rich granule lumen	Heat shock protein HSP 90-alpha	Homo sapiens (human)
protein-containing complex	Heat shock protein HSP 90-alpha	Homo sapiens (human)
plasma membrane	Heat shock protein HSP 90-alpha	Homo sapiens (human)
neuronal cell body	Heat shock protein HSP 90-alpha	Homo sapiens (human)
perinuclear region of cytoplasm	Heat shock protein HSP 90-alpha	Homo sapiens (human)
myelin sheath	Heat shock protein HSP 90-alpha	Homo sapiens (human)
cytosol	Heat shock protein HSP 90-alpha	Homo sapiens (human)
nucleus	Heat shock protein HSP 90-alpha	Homo sapiens (human)
COP9 signalosome	Heat shock protein HSP 90-beta	Homo sapiens (human)
protein folding chaperone complex	Heat shock protein HSP 90-beta	Homo sapiens (human)
extracellular region	Heat shock protein HSP 90-beta	Homo sapiens (human)
nucleus	Heat shock protein HSP 90-beta	Homo sapiens (human)
nucleoplasm	Heat shock protein HSP 90-beta	Homo sapiens (human)
cytoplasm	Heat shock protein HSP 90-beta	Homo sapiens (human)
mitochondrion	Heat shock protein HSP 90-beta	Homo sapiens (human)
cytosol	Heat shock protein HSP 90-beta	Homo sapiens (human)
cell surface	Heat shock protein HSP 90-beta	Homo sapiens (human)
membrane	Heat shock protein HSP 90-beta	Homo sapiens (human)
secretory granule lumen	Heat shock protein HSP 90-beta	Homo sapiens (human)
melanosome	Heat shock protein HSP 90-beta	Homo sapiens (human)
neuronal cell body	Heat shock protein HSP 90-beta	Homo sapiens (human)
dendritic growth cone	Heat shock protein HSP 90-beta	Homo sapiens (human)
axonal growth cone	Heat shock protein HSP 90-beta	Homo sapiens (human)
perinuclear region of cytoplasm	Heat shock protein HSP 90-beta	Homo sapiens (human)
extracellular exosome	Heat shock protein HSP 90-beta	Homo sapiens (human)
dynein axonemal particle	Heat shock protein HSP 90-beta	Homo sapiens (human)
ficolin-1-rich granule lumen	Heat shock protein HSP 90-beta	Homo sapiens (human)
protein-containing complex	Heat shock protein HSP 90-beta	Homo sapiens (human)
aryl hydrocarbon receptor complex	Heat shock protein HSP 90-beta	Homo sapiens (human)
HSP90-CDC37 chaperone complex	Heat shock protein HSP 90-beta	Homo sapiens (human)
perinuclear region of cytoplasm	Heat shock protein HSP 90-beta	Homo sapiens (human)
plasma membrane	Heat shock protein HSP 90-beta	Homo sapiens (human)
cytosol	Heat shock protein HSP 90-beta	Homo sapiens (human)
plasma membrane	Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)
sarcoplasmic reticulum lumen	Endoplasmin	Canis lupus familiaris (dog)
melanosome	Endoplasmin	Canis lupus familiaris (dog)
plasma membrane	Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)
plasma membrane	Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (46)

Assay ID	Title	Year	Journal	Article
AID266548	Inhibition of human SKBR3 cell growth	2006	Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15	Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
AID266553	Upregulation of Hsp70 in SKOV3 cells	2006	Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15	Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
AID273351	Induction of Hsp90-mediated AKT degradation in human LS174T cells in presence of HuCC49deltaCH2-beta galactosidase conjugate by Western blotting at 2 uM	2006	Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21	Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates.
AID273354	Induction of Hsp90-mediated AKT degradation in human LS174T cells in absence of HuCC49deltaCH2-beta galactosidase by Western blotting at 10 uM	2006	Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21	Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates.
AID465301	Apparent volume of distribution in tumor of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID201632	Inhibition of oncogene product p185 erbB-2 from human breast cancer cells(SK-BR-3 cells) at 50 mg/kg dose.	1995	Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19	Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives.
AID273353	Induction of Hsp90-mediated AKT degradation in human LS174T cells in presence of HuCC49deltaCH2-beta galactosidase conjugate by Western blotting at 10 uM	2006	Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21	Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates.
AID266552	Upregulation of Hsp70 in SKBR3 cells	2006	Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15	Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
AID465298	AUC in tumor of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465315	AUC in human at 220 mg/m2 administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465306	Half life in plasma of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465314	Half life in human at 220 mg/m2 administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465299	AUC in liver of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID201635	In vitro inhibition of p185 erbB-2 oncoprotein in human breast cancer SK-BR-3 cells	1995	Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19	erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships.
AID266546	Inhibition of BODIPY-AG binding to human HSP90	2006	Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15	Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
AID465300	Apparent volume of distribution in plasma of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465281	Inhibition of HSP90-mediated client protein HER2 degradation in human MCF7 cells	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465312	Cmax in human at 220 mg/m2 administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID266550	Degradation of Her2 in SKBR3 cells	2006	Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15	Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
AID115733	In vivo inhibition of p185 phosphotyrosine in nu/nu nude mice bearing Fisher rat embryo cells transfected with human erbB-2 at 400 mg/kg	1995	Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19	erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships.
AID465295	Cmax in tumor of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465308	Half life in liver of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID266547	Inhibition of BODIPY-AG binding to dog Grp94	2006	Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15	Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
AID465317	Volume of distribution at steady state in human at 220 mg/m2 administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465307	Half life in tumor of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID254267	Binding affinity for human heat shock protein 90 in scintillation proximity assay	2005	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 15, Issue:22	Structure-based design of 7-carbamate analogs of geldanamycin.
AID201637	In vitro inhibition of phospho-p185erbB-2 expression in human breast cancer cells(SK-BR-3 cells) at 100 mg/kg dose.	1995	Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19	Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives.
AID307450	Cell viability of mouse P19 derived neurons at 1 nM by XTT reduction assay relative to control	2007	Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10	Geldanamycin derivatives and neuroprotective effect on cultured P19-derived neurons.
AID465289	Binding affinity to HSP90 under reducing conditions in presence of TECP	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465303	Clearance in plasma of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465294	Cmax in plasma of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID201640	In vitro inhibition of phospho-p185erbB-2 expression in human breast cancer cells(SK-BR-3 cells) at 200 mg/kg dose.	1995	Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19	Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives.
AID255773	Cytotoxicity against SKBr3 cells	2005	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 15, Issue:22	Structure-based design of 7-carbamate analogs of geldanamycin.
AID350567	Cytotoxicity against human SKBR3 cells after 72 hrs by celltiter-glo assay	2009	Journal of medicinal chemistry, May-28, Volume: 52, Issue:10	Potent cytotoxic C-11 modified geldanamycin analogues.
AID350568	Binding affinity to human recombinant HSP90	2009	Journal of medicinal chemistry, May-28, Volume: 52, Issue:10	Potent cytotoxic C-11 modified geldanamycin analogues.
AID465305	Clearance in liver of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID266551	Degradation of Her2 in SKOV3 cells	2006	Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15	Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
AID465283	Inhibition of HSP90-mediated client protein HER2 degradation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465302	Apparent volume of distribution in liver of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465293	Binding affinity to HSP90 under non-reducing conditions in absence of TECP	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465304	Clearance in tumor of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID273352	Induction of Hsp90-mediated AKT degradation in human LS174T cells in absence of HuCC49deltaCH2-beta galactosidase by Western blotting at 2 uM	2006	Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21	Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates.
AID266549	Inhibition of human SKOV3 cell growth	2006	Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15	Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
AID465297	AUC in plasma of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465313	Tmax in human at 220 mg/m2 administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
AID465296	Cmax in liver of mouse bearing human A2780 cells at 80 mg/kg, ip administered as DMSO/egg phospholipid formulation	2010	Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1	Heat shock protein 90: inhibitors in clinical trials.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (22.22)	18.2507
2000's	6 (66.67)	29.6817
2010's	1 (11.11)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (11.11%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (88.89%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
adenosine diphosphate Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.	2.03	1	0	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite
thiazoles [no description available]	2.03	1	0	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2h-tetrazolium 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium: structure given in first source	2.03	1	0
geldanamycin [no description available]	3.27	6	0	1,4-benzoquinones; ansamycin; carbamate ester; organic heterobicyclic compound	antimicrobial agent; antineoplastic agent; antiviral agent; cysteine protease inhibitor; Hsp90 inhibitor
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: structure in first source. alvespimycin : A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.	2.95	4	0	1,4-benzoquinones; ansamycin; carbamate ester; secondary amino compound; tertiary amino compound	Hsp90 inhibitor
geldanamycin [no description available]	2.03	1	0
tanespimycin CP 127374: analog of herbimycin A	4.79	7	1	1,4-benzoquinones; ansamycin; carbamate ester; organic heterobicyclic compound; secondary amino compound	antineoplastic agent; apoptosis inducer; Hsp90 inhibitor
cnf 2024 [no description available]	2.05	1	0	2-aminopurines; aromatic ether; organochlorine compound; pyridines	antineoplastic agent; Hsp90 inhibitor
snx 2112 SNX 2112: an orally available small molecule Hsp90 inhibitor; structure in first source	2.05	1	0
ver 52296 luminespib : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(2,4-dihydroxy-5-isopropylphenyl)-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxylic acid with the amino group of ethylamine.	2.05	1	0	aromatic amide; isoxazoles; monocarboxylic acid amide; morpholines; resorcinols	angiogenesis inhibitor; antineoplastic agent; Hsp90 inhibitor

Condition	Relationship Strength	Studies	Trials
Breast Cancer [description not available]	2.39	2	0
Breast Neoplasms Tumors or cancer of the human BREAST.	2.39	2	0
Cancer of Colon [description not available]	2.03	1	0
Colonic Neoplasms Tumors or cancer of the COLON.	2.03	1	0
Recrudescence [description not available]	3.42	1	1
Benign Neoplasms [description not available]	3.42	1	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.42	1	1

ipi 493

Description

Cross-References

Synonyms (21)

Research Excerpts

Dosage Studied

Protein Targets (19)

Inhibition Measurements

Activation Measurements

Biological Processes (54)

Molecular Functions (40)

Ceullar Components (33)

Bioassays (46)

Research

Studies (9)

Market Indicators

Research Demand Index: 17.54

Study Types

ipi 493

Description

Cross-References

Synonyms (21)

Research Excerpts

Dosage Studied

Protein Targets (19)

Inhibition Measurements

Activation Measurements

Biological Processes (54)

Molecular Functions (40)

Ceullar Components (33)

Bioassays (46)

Research

Studies (9)

Market Indicators

Research Demand Index: 17.54

Study Types

Related Drugs (10)

Related Conditions (7)