AGN 191701: retinoid X receptors agonist; RN refers to (E)-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6438168 |
| CHEMBL ID | 93628 |
| SCHEMBL ID | 3685267 |
| MeSH ID | M0281857 |
| Synonym |
|---|
| CHEMBL93628 , |
| bdbm50032225 |
| 5-[(e)-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-thiophene-3-carboxylic acid |
| agn 191701 |
| (e)-5-(2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propenyl)-3-thiophenecarboxylic acid |
| 3-thiophenecarboxylic acid, 5-(2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propenyl)-, (e)- |
| (e)-5-(2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)propen-1-yl)-3-thiophenecarboxylic acid |
| 2-(2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphtyl)-propen-1-yl)-4-thiophene carboxylic acid |
| cd 2425 |
| 5-[(e)-2-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]thiophene-3-carboxylic acid |
| 2-(2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)propen-1-yl)-4-thiophenecarboxylic acid |
| 5-(2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propenyl)-3-thiophenecarboxylic acid |
| 156691-84-8 |
| agn-191701 |
| SCHEMBL3685267 |
| agn191701 |
| DTXSID201318486 |
| 3-thiophenecarboxylic acid, 5-[(1e)-2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propen-1-yl]- |
| AKOS040745511 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor alpha | Homo sapiens (human) | EC50 (µMol) | 0.0000 | 0.0002 | 0.1790 | 2.5119 | AID200108 |
| Retinoic acid receptor beta | Homo sapiens (human) | EC50 (µMol) | 0.0000 | 0.0003 | 0.2311 | 6.9000 | AID198201 |
| Retinoic acid receptor gamma | Homo sapiens (human) | EC50 (µMol) | 0.0000 | 0.0002 | 0.0613 | 0.6480 | AID198713 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | EC50 (µMol) | 0.2010 | 0.0001 | 0.3427 | 9.1000 | AID199477 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID199477 | Transcriptional activation of Retinoid X receptor RXR alpha | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID114618 | Inhibition of tumor-promoter-induced ornithine decarboxylase in TPA-treated female hairless mice | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID198713 | Transcriptional activation of Retinoic acid receptor RAR gamma | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID81281 | Transglutaminase activity in HL-60 cdm-1 cells | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID139988 | In vitro inhibition of chondrogenesis in mouse embryo limb bud cells | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID198201 | Transcriptional activation of Retinoic acid receptor RAR beta | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| AID200108 | Transcriptional activation of Retinoic acid receptor RAR alpha | 1995 | Journal of medicinal chemistry, Jul-21, Volume: 38, Issue:15 | Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.40) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||