| Assay ID | Title | Year | Journal | Article |
|---|
| AID154156 | Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes | 2001 | Journal of medicinal chemistry, Jan-18, Volume: 44, Issue:2
| Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins. |
| AID60434 | Tested for percent increase in coronary sinus partial pressure of oxygen (PO2) in open chest anesthetized dog at intravenous dosage of 0.10 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID677434 | Selectivity ratio of Ki for human A2A adenosine receptor expressed in HEK293 cells to Ki for human A1 adenosine receptor expressed in CHO cells | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. |
| AID1694547 | Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) after 24 hrs by fluorescence polarization assay | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
| AID117234 | Lethal dose in mice after intraperitoneal administration | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID58941 | Total time in minutes elapsed from the initiation of the change until return to the pretest value of heart rate in coronary sinus of anesthetized dog at intravenous dosage of 0.1 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID32345 | Ability to displace radioligand [3H]- DPCPX from adenosine A1 receptor on rat cortical membrane in the absence of GTP | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| 5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors. |
| AID34876 | Ability to displace radioligand [125I]AB-MECA from membrane of HEK 293 cells stably transfected with human adenosine A3 receptor cDNA | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| 5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors. |
| AID57871 | Tested for the percent increase in aortic blood pressure (BP) in open chest anesthetized dog at intravenous dosage of 1.00 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID677429 | Displacement of [125I]I-AB-MECA from human A3 adenosine receptor expressed in CHO cells after 60 mins gamma counter | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. |
| AID58803 | Total time in minutes elapsed from the initiation of the change until return to the pretest value of blood pressure in coronary sinus of anesthetized dog at intravenous dosage of 1 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID33162 | Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| 5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors. |
| AID677430 | Displacement of 3[H]R-PIA from rat A1 adenosine receptor expressed in CHO cells after 60 min by Liquid scintillation analysis | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. |
| AID60439 | Tested for the percent increase in coronary sinus partial pressure of oxygen (PO2) in open chest anesthetized dog at intravenous dosage of 1.00 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID117236 | Lethal dose in mice after peroral administration | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID58954 | Total time in minutes elapsed from the initiation of the change until return to the pretest value of oxygen partial pressure in coronary sinus of anesthetized dog at intravenous dosage of 1 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID677427 | Displacement of 3[H]R-PIA from human A1 adenosine receptor expressed in CHO cells after 60 mins by Liquid scintillation analysis | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. |
| AID1694546 | Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assay | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
| AID226458 | GTP shift was determined | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| 5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors. |
| AID58678 | Tested for the percent increase in heart rate (HR) in open chest anesthetized dog at intravenous dosage of 1.00 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID58809 | tested for the percent increase in heart rate (HR) in open chest anesthetized dog at intravenous dosage of 0.10 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID677435 | Agonist activity at human A1 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins relative to NECA | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. |
| AID58952 | Total time in minutes elapsed from the initiation of the change until return to the pretest value of oxygen partial pressure in coronary sinus of anesthetized dog at intravenous dosage of 0.1 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID1694550 | Selectivity index, ratio of Kd for displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assay to Kd for displacement of FITC-geldanamycin from HSP90alpha (unknown origin) after 24 hrs by fluorescence pola | 2021 | ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
| Biological Evaluation of 5'-( |
| AID32890 | Ability to displace radioligand [3H]- CGS 21680 from adenosine A2A receptor on rat striatal membrane | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| 5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors. |
| AID32346 | Ability to displace radioligand [3H]- DPCPX from adenosine A1 receptor on rat cortical membrane in the presence of 1 mM of GTP | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
| 5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors. |
| AID57870 | Tested for the percent increase in aortic blood pressure (BP) in open chest anesthetized dog at intravenous dosage of 0.10 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID58943 | Total time in minutes elapsed from the initiation of the change until return to the pretest value of heart rate in coronary sinus of anesthetized dog at intravenous dosage of 1 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID58801 | Total time in minutes elapsed from the initiation of the change until return to the pretest value of blood pressure in coronary sinus of anesthetized dog at intravenous dosage of 0.1 mg/kg | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
| Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides. |
| AID677431 | Displacement of 3[H]CGS21680 from rat A2A adenosine receptor expressed in HEK293 cells after 60 min by Liquid scintillation analysis | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. |
| AID677428 | Displacement of 3[H]CGS21680 from human A2A adenosine receptor expressed in HEK293 cells after 60 mins by Liquid scintillation analysis | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |