| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID716043 | AUC (infinity) in DBA1 mouse plasma at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715810 | Inhibition of Hsp90 in human BT474 cells assessed as degradation of cyclin D | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716032 | Drug uptake in human NCI-N87 cells xenografted in mouse at 6 to 12 mg/kg, po administered as a single dose at 6 to 24 hrs | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716045 | Tmax in DBA1 mouse plasma at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716014 | Cytotoxicity against human NCI-H295 cells overexpressing PGP xenografted in athymic mouse assessed as inhibition of tumor growth at 8 mg/kg, po qd for 5 days per week for 4 weeks | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715820 | Inhibition of Hsp90 in human NCI-N87 cells assessed as degradation of Akt | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715813 | Inhibition of Hsp90 in human BT474 cells assessed as degradation of ERK | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716015 | Toxicity in po dosed human N87 cell xenografted athymic mouse administered as qd for 5 days per week for 4 weeks | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716035 | Ratio of AUC (infinity) in lymph nodes to AUC (infinity) in plasma in DBA1 mouse at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716038 | Half life in DBA1 mouse brain at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716067 | Fraction unbound at human plasma | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716049 | Cmax in DBA1 mouse plasma at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716064 | Intrinsic clearance in human liver microsomes | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715814 | Inhibition of Hsp90 in human BT474 cells assessed as degradation of IGFR | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715823 | Inhibition of Hsp90 in human NCI-N87 cells assessed as degradation of EGFR | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715807 | Inhibition of Hsp90 in human BT474 cells assessed as effect on p85 PI3K | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715819 | Inhibition of Hsp90 in human NCI-N87 cells assessed as degradation of Rb | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716069 | Fraction unbound at mouse plasma | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716037 | Half life in DBA1 mouse lymph nodes at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715817 | Inhibition of Hsp90 in human NCI-N87 cells assessed as degradation of cdck6 | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716070 | Efflux ratio of apparent permeability from basolateral to apical side to apical to basolateral side of human Caco2 cells | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716040 | AUC (infinity) in DBA1 mouse spleen at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716048 | Cmax in DBA1 mouse lymph nodes at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716018 | Cytotoxicity against human NCI-N87 cell xenografted in athymic mouse assessed as inhibition of tumor growth at 5 mg/kg, po qd for 5 days per week for 4 weeks | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715815 | Inhibition of Hsp90 in human BT474 cells assessed as degradation of EGFR | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716029 | Drug uptake in human NCI-N87 cell xenografted mouse serum at 6 to 12 mg/kg, po administered as a single dose at 6 to 24 hrs | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716008 | Ratio of EC50 of BIIB021 to EC50 of compound for Hsp90alpha in human MCF7 cells assessed as degradation of Her-2 | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715811 | Inhibition of Hsp90 in human BT474 cells assessed as degradation of Rb | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716025 | Inhibition of Hsp90 in human BT474 cell xenografted mouse assessed as degradation of phosphorylated RAf at 4 to 8 mg/kg, po administered as a single dose at 6 to 48 hrs by Western blot method | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715821 | Inhibition of Hsp90 in human NCI-N87 cells assessed as degradation of ERK | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716061 | Tmax in CD-1 mouse at 25 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716022 | Inhibition of Hsp90 in human BT474 cell xenografted mouse assessed as degradation of phosphorylated Rb at 4 to 8 mg/kg, po administered as a single dose at 6 to 48 hrs by Western blot method | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716010 | Toxicity in human NCI-N87 xenografted athymic mouse assessed as reduction in body weight at >10 mg/kg, po qd for 5 days per week for 4 weeks | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716019 | Inhibition of Hsp90 in human BT474 cell xenografted mouse assessed as effect on PI3K at 4 to 8 mg/kg, po administered as a single dose at 6 to 48 hrs by Western blot method | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715818 | Inhibition of Hsp90 in human NCI-N87 cells assessed as degradation of cyclin D | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715822 | Inhibition of Hsp90 in human NCI-N87 cells assessed as degradation of IGFR | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716076 | Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2 | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716058 | AUC in CD-1 mouse at 25 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716071 | Inhibition of Hsp90alpha | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716066 | Intrinsic clearance in mouse liver microsomes | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715824 | Inhibition of Hsp90 in human NCI-N87 cells assessed as degradation of Her-2 | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715808 | Inhibition of Hsp90 in human BT474 cells assessed as up-regulation of Hsp70 | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716041 | AUC (infinity) in DBA1 mouse lymph nodes at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716052 | Half life in CD-1 mouse at 25 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716073 | Binding affinity at TRAP1 incubated for 16 hrs by fluorescence polarization competition assay | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716046 | Tmax in DBA1 mouse brain at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716026 | Inhibition of Hsp90 in human BT474 cell xenografted mouse assessed as degradation of phosphorylated AKT at 4 to 8 mg/kg, po administered as a single dose at 6 to 48 hrs by Western blot method | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716282 | Inhibition of Hsp90 in human BT474 cells assessed as degradation of Her-2 | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716028 | Inhibition of Hsp90 in human BT474 cell xenografted mouse assessed as degradation of Her-2 at 4 to 8 mg/kg, po administered as a single dose at 6 to 48 hrs by Western blot method | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716021 | Inhibition of Hsp90 in human BT474 cell xenografted mouse assessed as up-regulation of Hsp70 at 4 to 8 mg/kg, po administered as a single dose at 6 to 48 hrs by Western blot method | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716027 | Inhibition of Hsp90 in human BT474 cell xenografted mouse assessed as degradation of phosphorylated Her-2 at 4 to 8 mg/kg, po administered as a single dose at 6 to 48 hrs by Western blot method | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716072 | Ratio of AUC (infinity) in brain to AUC (infinity) in plasma in DBA1 mouse at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716077 | Apparent permeability from apical to basolateral side of human Caco2 cells | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716044 | Tmax in DBA1 mouse lymph nodes at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716055 | Dose normalized AUC in CD-1 mouse at 25 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716075 | Binding affinity at recombinant Hsp90alpha incubated for 16 hrs by fluorescence polarization competition assay | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716078 | Initial Cmax in CD-1 mouse at 25 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715809 | Inhibition of Hsp90 in human BT474 cells assessed as degradation of cdck6 | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715812 | Inhibition of Hsp90 in human BT474 cells assessed as degradation of Akt | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716023 | Inhibition of Hsp90 in human BT474 cell xenografted mouse assessed as degradation of cdk6 at 4 to 8 mg/kg, po administered as a single dose at 6 to 48 hrs by Western blot method | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716024 | Inhibition of Hsp90 in human BT474 cell xenografted mouse assessed as degradation of phosphorylated ERK at 4 to 8 mg/kg, po administered as a single dose at 6 to 48 hrs by Western blot method | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715816 | Inhibition of Hsp90 in human NCI-N87 cells assessed as up-regulation of Hsp70 | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716020 | Inhibition of Hsp90 in human BT474 cell xenografted mouse assessed as up-regulation of Hsp27 at 4 to 8 mg/kg, po administered as a single dose at 6 to 48 hrs by Western blot method | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716011 | Inhibition of Hsp90 in B6D2F1 mouse assessed as up regulation of Hsp70 in brain at 30 to 60 mg/kg, po after 24 hrs by ELISA relative to vehicle treated control | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716047 | Cmax in DBA1 mouse spleen at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716017 | Cytotoxicity against human NCI-N87 cell xenografted in athymic mouse assessed as inhibition of tumor growth at 10 mg/kg, po qd for 5 days per week for 4 weeks | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716036 | Half life in DBA1 mouse spleen at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716030 | Drug uptake in human NCI-N87 cell xenografted mouse brain at 6 to 12 mg/kg, po administered as a single dose at 6 to 24 hrs | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716065 | Intrinsic clearance in rat liver microsomes | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716068 | Fraction unbound at rat plasma | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716050 | Cmax in DBA1 mouse brain at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID715806 | Antitumor activity against human NCI-N87 cells xenografted in po dosed athymic mouse administered as qd for 5 days per week for 4 weeks relative to BIIB021 | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716034 | Ratio of AUC (infinity) in spleen to AUC (infinity) in plasma in DBA1 mouse at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716079 | Effect on p85 PI3K in human NCI-N87 cells assessed as effect on p85 PI3K | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716039 | Half life in DBA1 mouse plasma at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716033 | Toxicity in po dosed mouse administered as a single dose | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716042 | AUC (infinity) in DBA1 mouse brain at 5 mg/kg, po | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716031 | Drug uptake in human NCI-N87 cell xenografted mouse spleen at 6 to 12 mg/kg, po administered as a single dose at 6 to 24 hrs | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716009 | Toxicity in human NCI-N87 xenografted athymic mouse assessed as diarrhea at >10mg/kg, po qd for 5 days per week for 4 weeks | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID716074 | Binding affinity at Grp94 incubated for 16 hrs by fluorescence polarization competition assay | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| EC144 is a potent inhibitor of the heat shock protein 90. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2011 | Journal of immunology (Baltimore, Md. : 1950), Jan-01, Volume: 186, Issue:1
| EC144, a synthetic inhibitor of heat shock protein 90, blocks innate and adaptive immune responses in models of inflammation and autoimmunity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |