spiruchostatin A: a potent histone deacetylase inhibitor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 11178958 |
| CHEMBL ID | 3126832 |
| SCHEMBL ID | 8063682 |
| MeSH ID | M0466225 |
| Synonym |
|---|
| spiruchostatin a |
| SCHEMBL8063682 |
| obp-801 |
| CHEMBL3126832 |
| ym-753 |
| cyclo(d-alanyl-d-cysteinyl-(3s,4r)-4-amino-3-hydroxy-5-methylhexanoyl-(3s,4e)-3-hydroxy-7-mercapto-4-heptenoyl), cyclic (2->4)-disulfide |
| cyclo(d-alanyl-d-cysteinyl-(3s,4r)-4-amino-3-hydroxy-5-methylhexanoyl-(3s,4e)-3-hydroxy-7-mercapto-4-heptenoyl), cyclic (2-4)-disulfide |
| 30q3vs5hz4 , |
| ym 753 |
| 328548-11-4 |
| unii-30q3vs5hz4 |
| bdbm50505365 |
| DB12279 |
| (1s,5s,6r,9s,20r,e)-5-hydroxy-6-isopropyl-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetraone |
| Q27255970 |
| (1s,5s,6r,9s,15e,20r)-5-hydroxy-20-methyl-6-propan-2-yl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetrone |
| DTXSID301029731 |
Spiruchostatin A (SpA) is a histone deacetylase inhibitor (HDI) with selectivity toward Class I enzymes.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Spiruchostatin A (SpA) is a histone deacetylase inhibitor (HDI) with selectivity toward Class I enzymes, which distinguishes it from other nonspecific HDIs that are reported to inhibit (myo)fibroblast proliferation and differentiation." | ( Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis. Davies, DE; Davies, ER; Ganesan, A; Haitchi, HM; Kottmann, RM; O'Reilly, KM; Packham, G; Sime, PJ; Thatcher, TH, 2012) | 2.54 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Histone deacetylase 1 | Homo sapiens (human) | IC50 (µMol) | 0.0033 | 0.0001 | 0.5543 | 9.9000 | AID1525777 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 (µMol) | 1.6000 | 0.0000 | 0.5376 | 9.9000 | AID1525776 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1525777 | Inhibition of HADC1 (unknown origin) | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1 | Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases. |
| AID1525776 | Inhibition of HADC6 (unknown origin) | 2020 | Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1 | Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases. |
| AID1077072 | Selectivity index, ratio of IC50 for mouse HDAC6 to IC50 for human HDAC1 | 2014 | European journal of medicinal chemistry, Apr-09, Volume: 76 | Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.01) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (7.69%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (92.31%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||