| Assay ID | Title | Year | Journal | Article |
|---|
| AID198064 | Percent activation of Retinoic acid receptor alpha at 1 uM relative to 1 uM trans-retinoic acid | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12
| 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists. |
| AID198738 | Binding affinity to retinoic acid receptor (RAR) gamma using [3H]CD 367 as radioligand | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. |
| AID150718 | Inhibition of the induction of ornithine decarboxylase in mouse epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (ODC) at dose 1.7 nmol | 1984 | Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
| Conformationally restricted retinoids. |
| AID231582 | Relative activity as reciprocal of the ratio of ED50 (retinoid) / ED50 (retinoic acid) when control was 7 x 10e-12 | 1983 | Journal of medicinal chemistry, Nov, Volume: 26, Issue:11
| Synthesis and pharmacological activity of 6-[(E)-2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethen-1-yl]- and 6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acids. |
| AID166122 | cross-linked envelope inhibition assay was performed at 10 nM compound concentration | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
| Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. |
| AID68786 | Ability to displace 3 uM retinoid and [3H]all-trans-retinoic acid in F9 embryonal carcinoma cells using F9 Plasminogen Activator releasing assay | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
| Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. |
| AID83825 | Activity of compound the was expressed as ratio of active hamster tracheal organ cultures(TOC) to the total cultures at 10e-10 M concentration; 21/22 | 1984 | Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
| Conformationally restricted retinoids. |
| AID199064 | Percent activation of Retinoic acid receptor gamma receptor at 1 uM relative to 1 uM trans-retinoic acid | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12
| 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists. |
| AID198222 | Binding affinity to retinoic acid receptor beta using [3H]CD 367 as radioligand | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. |
| AID150874 | Inhibitory effect of compound on the induction of ornithine decarboxylase in CD-1 mouse. | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
| Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. |
| AID288573 | Induction of terminal differentiation in mouse F9 cells assessed by measuring secreted plasminogen activator activity after 3 days | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and |
| AID52065 | Concentration of compound required to inhibit binding of 2.5 uM [3H]all-trans-retinoic acid by 50% in chick | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
| Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. |
| AID166117 | Percentage inhibition of cholesterol-3-sulfate activity in rabbit at 0.1 nM. | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
| Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. |
| AID210769 | Inhibitory dose against tracheal organ culture reversal of keratinization | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
| Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. |
| AID166118 | Percentage inhibition of cholesterol-3-sulfate activity rabbit at 10 nM. | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
| Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. |
| AID83975 | Activity of compound the was expressed as ratio of active hamster tracheal organ cultures(TOC) to the total cultures at 10e-12 M concentration; 4/15 | 1984 | Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
| Conformationally restricted retinoids. |
| AID198553 | Percent activation of Retinoic acid receptor beta at 1 uM relative to 1 uM trans-retinoic acid | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12
| 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists. |
| AID288574 | Inhibition of TPA-induced ornithine decarboxylase in mouse dorsal epidermis applied topically after 1 hr | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and |
| AID68777 | In vitro promotion of plasminogen activator secretion from F9 (murine teratocarcinoma) cells. | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. |
| AID150719 | Inhibition of the induction of ornithine decarboxylase in mouse epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (ODC) at dose 17 nmol | 1984 | Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
| Conformationally restricted retinoids. |
| AID87278 | Reversal of keratinization process in hamster tracheal organ culture at concentration of 10e-11 M expressed as percent of active cultures out of 22 cultures | 1983 | Journal of medicinal chemistry, Nov, Volume: 26, Issue:11
| Synthesis and pharmacological activity of 6-[(E)-2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethen-1-yl]- and 6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acids. |
| AID7227 | Transcriptional activation in CV-1 cells expressing retinoic acid gamma receptor | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12
| 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists. |
| AID197905 | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor alpha | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12
| 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists. |
| AID150726 | Percent inhibition of induction of ODC(ornithine decarboxylase) by TPA in mouse skin at a dose of 17.0 nmol | 1983 | Journal of medicinal chemistry, Nov, Volume: 26, Issue:11
| Synthesis and pharmacological activity of 6-[(E)-2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethen-1-yl]- and 6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acids. |
| AID87396 | Reversal of keratinization process in hamster tracheal organ culture at concentration of 10e-9 M expressed as percent of active cultures out of 7 cultures | 1983 | Journal of medicinal chemistry, Nov, Volume: 26, Issue:11
| Synthesis and pharmacological activity of 6-[(E)-2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethen-1-yl]- and 6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acids. |
| AID87277 | Reversal of keratinization process in hamster tracheal organ culture at concentration of 10e-10 M expressed as percent of active cultures out of 22 cultures | 1983 | Journal of medicinal chemistry, Nov, Volume: 26, Issue:11
| Synthesis and pharmacological activity of 6-[(E)-2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethen-1-yl]- and 6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acids. |
| AID87280 | Reversal of keratinization process in hamster tracheal organ culture at concentration of 10e-12 M expressed as percent of active cultures out of 15 cultures | 1983 | Journal of medicinal chemistry, Nov, Volume: 26, Issue:11
| Synthesis and pharmacological activity of 6-[(E)-2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethen-1-yl]- and 6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acids. |
| AID167591 | Percent activation of Retinoic acid receptor RXR-alpha at 1 uM relative to 1 uM 9-cis-retinoic acid | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12
| 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists. |
| AID84854 | Molarity required to effect reversal of keratinization in 50% of cultures. | 1984 | Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
| Conformationally restricted retinoids. |
| AID198360 | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor beta | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12
| 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists. |
| AID288572 | Reversal of keratinization in vitamin A-deficient hamster trachea after 10 days by TOC assay | 2007 | Journal of medicinal chemistry, May-31, Volume: 50, Issue:11
| An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and |
| AID83971 | Activity of compound the was expressed as ratio of active hamster tracheal organ cultures(TOC) to the total cultures at 10e-11 M concentration; 17/22 | 1984 | Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
| Conformationally restricted retinoids. |
| AID210789 | Percentage inhibition of Transglutaminase activity in rabbit at 10 nM. | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
| Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. |
| AID167587 | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RXR-alpha | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12
| 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists. |
| AID68787 | Ability to displace [3H]all-trans-retinoic acid from F9 embryonal carcinoma cells, was assessed in a F9 laminin release assay | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
| Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. |
| AID150725 | Percent inhibition of induction of ODC(ornithine decarboxylase) by TPA in mouse skin at a dose of 1.7 nmol | 1983 | Journal of medicinal chemistry, Nov, Volume: 26, Issue:11
| Synthesis and pharmacological activity of 6-[(E)-2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethen-1-yl]- and 6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acids. |
| AID200139 | Binding affinity to retinoic acid receptor alpha using [3H]CD 367 as radioligand | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. |
| AID52069 | Inhibition of binding of [3H]all-trans-retinoic acid to cellular retinoic acid binding protein at 3 uM compound concentration, in rat | 1989 | Journal of medicinal chemistry, Jul, Volume: 32, Issue:7
| Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |