| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347412 | qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347414 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Secondary screen by immunofluorescence | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1373034 | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate at 10 uM after 10 mins in presence of NADPH relative to control | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1373029 | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter-Glo assay | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1373027 | Inhibition of recombinant human full length N-terminal GST-tagged CK1delta expressed in baculovirus in Sf9 insect cells using ULight-Topo-IIa(Thr1342) peptide as substrate after 10 mins by TR-FRET assay | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1373050 | Oral bioavailability in C57BL6 mouse at 3 mg/kg measured up to 8 hrs by LC-MS/MS analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1854451 | Inhibition of CK1 delta (unknown origin) | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Current progress and novel strategies that target CDK12 for drug discovery. |
| AID1849033 | Induction of osteogenic differentiation in mouse C2C12 cells assessed as ALP activity preincubated with compound in the presence of BMP-4 for 72 hrs followed by substrate addition and measured after 1 hrs in the presence of PIK93 by luminescence based ass | 2022 | Journal of medicinal chemistry, 11-24, Volume: 65, Issue:22
| Phenotypic Discovery of Triazolo[1,5- |
| AID1373028 | Inhibition of recombinant human full length N-terminal GST-tagged CK1epsilon expressed in baculovirus in Sf9 insect cells using ULight-Topo-IIa(Thr1342) peptide as substrate after 10 mins by TR-FRET assay | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1849034 | Induction of osteogenic differentiation in mouse C2C12 cells assessed as ALP activity preincubated with compound in the presence of BMP-4 for 72 hrs followed by substrate addition and measured after 1 hrs in the presence of BYL719 by luminescence based as | 2022 | Journal of medicinal chemistry, 11-24, Volume: 65, Issue:22
| Phenotypic Discovery of Triazolo[1,5- |
| AID1373047 | Half life in C57BL6 mouse at 3 mg/kg, po by LC-MS/MS analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1373031 | Half life in human liver microsomes at 1 uM by LC/MS analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1373044 | AUC in C57BL6 mouse at 3 mg/kg, po up to 8 hrs by LC-MS/MS analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1373036 | Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate at 10 uM after 10 mins in presence of NADPH relative to control | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1849031 | Activation of BMP signaling in HEK293T cells expressing BRE-Vent2 luciferase reporter gene assessed as BRE activation by measuring increase in luciferase activity measured after 22 hrs in the presence of BMP-4 by dual-luciferase assay | 2022 | Journal of medicinal chemistry, 11-24, Volume: 65, Issue:22
| Phenotypic Discovery of Triazolo[1,5- |
| AID1375071 | Toxicity in HEK293T cells at 0.5 to 5 uM after 6 to 22 hrs by CellTiter-Glo assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
| AID1854452 | Inhibition of CK1 epsilon (unknown origin) | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Current progress and novel strategies that target CDK12 for drug discovery. |
| AID1373038 | Cmax in C57BL6 mouse at 3 mg/kg, po by LC-MS/MS analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1373037 | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate at 10 uM after 10 mins in presence of NADPH relative to control | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1373041 | Clearance in C57BL6 mouse at 3 mg/kg, po up to 8 hrs by LC-MS/MS analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1373033 | Half life in rat liver microsomes at 1 uM by LC/MS analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1373035 | Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate at 10 uM after 10 mins in presence of NADPH relative to control | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1375076 | Inhibition of CK1delta/epsilon in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling up to 0.1 uM after 22 hrs by Super-top flash reporter gene assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
| AID1373053 | Apparent permeability at 5 uM after 5 hrs by PAMPA | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1849035 | Induction of osteogenic differentiation in mouse C2C12 cells assessed as ALP activity at 0.02 uM preincubated with compound in the presence of BMP-4 for 72 hrs followed by substrate addition and measured after 1 hrs in the presence of AS252424 by luminesc | 2022 | Journal of medicinal chemistry, 11-24, Volume: 65, Issue:22
| Phenotypic Discovery of Triazolo[1,5- |
| AID1375075 | Inhibition of CK1delta/epsilon in HEK293T cells assessed as suppression of Wnt/beta-catenin signaling up to 0.1 uM after 22 hrs in presence of Wnt3A-conditioned medium by Super-top flash reporter gene assay | 2018 | Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
| Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. |
| AID1854442 | Inhibition of CDK12 (unknown origin) | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Current progress and novel strategies that target CDK12 for drug discovery. |
| AID1373030 | Aqueous solubility of the compound at pH 7.4 measured after 24 hrs by HPLC analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| AID1373032 | Half life in mouse liver microsomes at 1 uM by LC/MS analysis | 2018 | Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
| Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |