Page last updated: 2024-11-12

r18 peptide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

R18 peptide: a 20-mer peptide, derived from a phage library, that binds 14-3-3 tau protein; amino acid sequence in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16138697
CHEMBL ID3814675
MeSH IDM0519664

Synonyms (3)

Synonym
r18 peptide
CHEMBL3814675 ,
bdbm50177028

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" In vitro studies demonstrated that R18 and R18D were most toxic to neurons, followed by astrocytes, HEK293 and bEND."( Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies.
Anderton, RS; Bakeberg, MC; Blacker, DJ; Clark, VW; Cross, JL; Knuckey, NW; Meloni, BP; Milani, D, 2018
)
0.48
"5 and 1 µM) reduced the toxic effects of rtPA and OGD/rtPA, while on some occasions a higher 2 µM R18D concentrations exacerbated neuronal and bEnd."( Assessment of recombinant tissue plasminogen activator (rtPA) toxicity in cultured neural cells and subsequent treatment with poly-arginine peptide R18D.
Anderton, RS; Kenna, JE; Knuckey, NW; Meloni, BP, 2020
)
0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
14-3-3 protein thetaHomo sapiens (human)Kd0.07000.07000.07000.0700AID1304818
14-3-3 protein beta/alphaHomo sapiens (human)Kd0.07000.07000.07000.0700AID1304817
14-3-3 protein etaHomo sapiens (human)Kd0.07000.07000.07000.0700AID1304819
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (22)

Processvia Protein(s)Taxonomy
protein targeting14-3-3 protein thetaHomo sapiens (human)
small GTPase-mediated signal transduction14-3-3 protein thetaHomo sapiens (human)
substantia nigra development14-3-3 protein thetaHomo sapiens (human)
negative regulation of monoatomic ion transmembrane transport14-3-3 protein thetaHomo sapiens (human)
negative regulation of DNA-templated transcription14-3-3 protein thetaHomo sapiens (human)
signal transduction14-3-3 protein thetaHomo sapiens (human)
protein localization14-3-3 protein thetaHomo sapiens (human)
protein targeting14-3-3 protein beta/alphaHomo sapiens (human)
negative regulation of protein dephosphorylation14-3-3 protein beta/alphaHomo sapiens (human)
positive regulation of catalytic activity14-3-3 protein beta/alphaHomo sapiens (human)
negative regulation of G protein-coupled receptor signaling pathway14-3-3 protein beta/alphaHomo sapiens (human)
cytoplasmic sequestering of protein14-3-3 protein beta/alphaHomo sapiens (human)
signal transduction14-3-3 protein beta/alphaHomo sapiens (human)
protein localization14-3-3 protein beta/alphaHomo sapiens (human)
regulation of sodium ion transport14-3-3 protein etaHomo sapiens (human)
glucocorticoid catabolic process14-3-3 protein etaHomo sapiens (human)
intracellular protein transport14-3-3 protein etaHomo sapiens (human)
substantia nigra development14-3-3 protein etaHomo sapiens (human)
intracellular glucocorticoid receptor signaling pathway14-3-3 protein etaHomo sapiens (human)
regulation of neuron differentiation14-3-3 protein etaHomo sapiens (human)
positive regulation of DNA-templated transcription14-3-3 protein etaHomo sapiens (human)
regulation of synaptic plasticity14-3-3 protein etaHomo sapiens (human)
negative regulation of dendrite morphogenesis14-3-3 protein etaHomo sapiens (human)
membrane depolarization during action potential14-3-3 protein etaHomo sapiens (human)
presynaptic modulation of chemical synaptic transmission14-3-3 protein etaHomo sapiens (human)
regulation of sodium ion transmembrane transporter activity14-3-3 protein etaHomo sapiens (human)
signal transduction14-3-3 protein etaHomo sapiens (human)
protein localization14-3-3 protein etaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (16)

Processvia Protein(s)Taxonomy
protein binding14-3-3 protein thetaHomo sapiens (human)
protein domain specific binding14-3-3 protein thetaHomo sapiens (human)
identical protein binding14-3-3 protein thetaHomo sapiens (human)
transmembrane transporter binding14-3-3 protein thetaHomo sapiens (human)
14-3-3 protein binding14-3-3 protein thetaHomo sapiens (human)
protein kinase inhibitor activity14-3-3 protein beta/alphaHomo sapiens (human)
protein binding14-3-3 protein beta/alphaHomo sapiens (human)
enzyme binding14-3-3 protein beta/alphaHomo sapiens (human)
protein domain specific binding14-3-3 protein beta/alphaHomo sapiens (human)
identical protein binding14-3-3 protein beta/alphaHomo sapiens (human)
histone deacetylase binding14-3-3 protein beta/alphaHomo sapiens (human)
cadherin binding14-3-3 protein beta/alphaHomo sapiens (human)
phosphoserine residue binding14-3-3 protein beta/alphaHomo sapiens (human)
phosphoprotein binding14-3-3 protein beta/alphaHomo sapiens (human)
actin binding14-3-3 protein etaHomo sapiens (human)
insulin-like growth factor receptor binding14-3-3 protein etaHomo sapiens (human)
protein binding14-3-3 protein etaHomo sapiens (human)
sodium channel regulator activity14-3-3 protein etaHomo sapiens (human)
enzyme binding14-3-3 protein etaHomo sapiens (human)
protein domain specific binding14-3-3 protein etaHomo sapiens (human)
nuclear glucocorticoid receptor binding14-3-3 protein etaHomo sapiens (human)
identical protein binding14-3-3 protein etaHomo sapiens (human)
transmembrane transporter binding14-3-3 protein etaHomo sapiens (human)
protein heterodimerization activity14-3-3 protein etaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (14)

Processvia Protein(s)Taxonomy
cytoplasm14-3-3 protein thetaHomo sapiens (human)
cytosol14-3-3 protein thetaHomo sapiens (human)
focal adhesion14-3-3 protein thetaHomo sapiens (human)
membrane14-3-3 protein thetaHomo sapiens (human)
synapse14-3-3 protein thetaHomo sapiens (human)
extracellular exosome14-3-3 protein thetaHomo sapiens (human)
protein-containing complex14-3-3 protein thetaHomo sapiens (human)
cytoplasm14-3-3 protein thetaHomo sapiens (human)
cytoplasm14-3-3 protein beta/alphaHomo sapiens (human)
vacuolar membrane14-3-3 protein beta/alphaHomo sapiens (human)
cytosol14-3-3 protein beta/alphaHomo sapiens (human)
focal adhesion14-3-3 protein beta/alphaHomo sapiens (human)
membrane14-3-3 protein beta/alphaHomo sapiens (human)
melanosome14-3-3 protein beta/alphaHomo sapiens (human)
perinuclear region of cytoplasm14-3-3 protein beta/alphaHomo sapiens (human)
extracellular exosome14-3-3 protein beta/alphaHomo sapiens (human)
cytoplasm14-3-3 protein beta/alphaHomo sapiens (human)
cytoplasm14-3-3 protein etaHomo sapiens (human)
cytosol14-3-3 protein etaHomo sapiens (human)
plasma membrane14-3-3 protein etaHomo sapiens (human)
intercalated disc14-3-3 protein etaHomo sapiens (human)
extracellular exosome14-3-3 protein etaHomo sapiens (human)
presynapse14-3-3 protein etaHomo sapiens (human)
cerebellar granule cell to Purkinje cell synapse14-3-3 protein etaHomo sapiens (human)
cytoplasm14-3-3 protein etaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1304819Binding affinity to GST-tagged 125I-labelled 14-3-3eta (unknown origin) expressed in Escherichia coli by solid phase assay2016Bioorganic & medicinal chemistry, Aug-01, Volume: 24, Issue:15
Small molecules that target phosphorylation dependent protein-protein interaction.
AID1304818Binding affinity to GST-tagged 125I-labelled full length human 14-3-3tau expressed in Escherichia coli by solid phase assay2016Bioorganic & medicinal chemistry, Aug-01, Volume: 24, Issue:15
Small molecules that target phosphorylation dependent protein-protein interaction.
AID1304817Binding affinity to GST-tagged 125I-labelled 14-3-3beta (unknown origin) expressed in Escherichia coli by solid phase assay2016Bioorganic & medicinal chemistry, Aug-01, Volume: 24, Issue:15
Small molecules that target phosphorylation dependent protein-protein interaction.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's9 (69.23)24.3611
2020's3 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index18.33 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.78 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (18.33)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]