Tardive Dyskinesia

Drug-related movement disorder characterized by uncontrollable movements in certain muscles. It is associated with a long-term exposure to certain neuroleptic medications (e.g., METOCLOPRAMIDE).

Synonym
Tardive Dyskinesia

Excerpt	Reference
"Tardive dyskinesia is defined as involuntary athetoid or choreiform movements that develop due to the use of neuroleptic drugs for at least a few months."	( Arat-Çelik, HE; Çetin, B; Kök-Kendirlioğlu, B; Küçükgöncü, S, 2021)
"Tardive dyskinesia is recognized as buccolingual dyskinesia, but also includes various involuntary movements, such as chorea, dystonia, myoclonus, and tremor."	( Nomoto, M, 2022)
"Tardive dyskinesia is a drug-induced involuntary movement related to long-term use of dopamine receptor-blocking agents."	( Ito, H; Sakata, M, 2022)
"While tardive dyskinesia is an involuntary movement disorder that often occurs gradually after long-term use of medications, it does not commonly present acutely."	( Agrawal, H; Thalner, S, 2023)
"Tardive dyskinesia is a serious, disabling, movement disorder associated with the ongoing use of antipsychotic medication."	( Scheel-Krüger, J; Szota, AM, 2020)
"Tardive dyskinesia is a persistent movement disorder induced by dopamine receptor blockers, including antipsychotics."	( Burke, J; Factor, SA; Hauser, RA; Jimenez, R; Knesevich, MA; Liang, GS; Marder, SR; O'Brien, CF; Ramirez, PM, 2017)
"Tardive dyskinesia is a potentially irreversible, debilitating, hyperkinetic movement disorder that can result from dopamine receptor antagonists."	( Nicewonder, JA; Peckham, AM, 2019)
"Tardive dyskinesia is a delayed and potentially irreversible motor complication arising from chronic exposure to antipsychotic drugs."	( Blanchet, PJ; Cyr, M; Diaz, J; Hernandez, G; Lévesque, D; Mahmoudi, S, 2019)
"Tardive dyskinesia is a common movement disorder in the population of patients taking dopamine receptor blocking agents, such as antipsychotics and certain antiemetics, which likely lead to D2-receptor upregulation and hypersensitization."	( Jimenez-Shahed, J; Niemann, N, 2019)
"Tardive dyskinesia is a movement disorder characterised by irregular, stereotyped, and choreiform movements associated with the use of antipsychotic medication."	( Addington, D; Barnes, TRE; Carson, A; Edwards, M; Gardner, D; Martino, D; Morgante, F; Poole, N; Pringsheim, T; Remington, G; Ricciardi, L, 2019)
"Preventing tardive dyskinesia is of primary importance, and clinicians should follow best practice for prescribing antipsychotic medication, including limiting the prescription for specific indications, using the minimum effective dose, and minimising the duration of therapy."	( Addington, D; Barnes, TRE; Carson, A; Edwards, M; Gardner, D; Martino, D; Morgante, F; Poole, N; Pringsheim, T; Remington, G; Ricciardi, L, 2019)
"Tardive dyskinesia is rarely caused by Aripiprazole and has only been documented in high risk patients i."	( Patra, S, 2016)

Excerpt	Reference
"At present, there is no satisfactory treatment for tardive dyskinesia."	( Chen, S; Guan, M; Qin, H; Xu, H, 2022)
"Valbenazine is approved in the US for treatment of tardive dyskinesia (TD); however, efficacy/safety data in Asian populations are lacking."	( Horiguchi, J; Iwatake, A; Kondo, K; Masui, H; Sakamoto, H; Susuta, Y; Watanabe, K; Watanabe, Y, 2022)
"Though clozapine is recommended for treatment of tardive dyskinesia (TD) relating to the use of antipsychotic medications, studies comprehensively investigating the treatment effect of clozapine on TD are still limited."	( Bastiampillai, T; Chan, SKW; Cheuk, NKW; Liao, Y; Pang, T; Wong, J, 2022)
"Early Recognition and Treatment of Tardive Dyskinesia in Patients With Mood Disorders and Schizophrenia Click to enlarge page."	( Kremens, DE; McEvoy, JP, 2020)
"The recent approval of treatments for tardive dyskinesia (TD) has rekindled interest in this chronic and previously recalcitrant condition."	( Harvey, PD; Rosenfeld, A; Strassnig, M, 2018)
"The two approved treatments for tardive dyskinesia both inhibit the vesicular monoamine transporter type 2 (VMAT2) yet have pharmacologic properties that distinguish one from the other."	( Stahl, SM, 2018)
"Few studies have assessed the treatment of tardive dyskinesia (TD) in patients with primary mood disorders who are managed with antipsychotics."	( Burke, J; Calabrese, JR; Farahmand, K; McIntyre, RS; Nierenberg, AA; Siegert, S; Yonan, C, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	112 (68.71)	28.8240
2020's	51 (31.29)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
thioctic acid	low	2	0
8-hydroxy-2-(di-n-propylamino)tetralin	low	2	0
3-nitropropionic acid	low	1	0
hydroxyindoleacetic acid	low	1	0
amantadine	low	2	0
dan 2163	low	1	0
baclofen	low	1	0
berberine	low	1	0
chlorpromazine	medium	2	1
clonazepam	low	3	0
desipramine	low	1	0
domperidone	low	1	0
donepezil	low	1	0
fluphenazine	low	2	0
gabapentin	low	1	0
haloperidol	low	22	0
imipramine	low	1	0
lamotrigine	low	1	0
mecamylamine	low	1	0
methylphenidate	low	1	0
metoclopramide	low	6	0
oxidopamine	low	1	0
oxybutynin	low	1	0
propranolol	low	3	0
risperidone	low	5	0
trihexyphenidyl	low	1	0
alanine	low	1	0
tetrabenazine	medium	86	15
carbostyril	low	1	0
levodopa	low	1	0
valine	medium	50	9
phencyclidine	low	1	0
thiophenes	low	1	0
ethyl acetate	low	1	0
galantamine	low	1	0
malondialdehyde	low	2	0
d-alpha tocopherol	low	3	0
pimozide	low	2	0
deuterium	low	3	0
phenyl acetate	low	1	0
glutamic acid	low	2	0
paroxetine	low	1	0
aripiprazole	low	16	0
duloxetine hydrochloride	low	1	0
nicotine	low	2	0
vitamin b 6	low	1	0
dihydrotetrabenazine	low	1	0
blonanserin	low	1	0
safinamide	low	1	0
2-naphthoylethyltrimethylammonium	low	1	0
theanine	low	1	0
naringin	low	1	0
cannabidiol	low	2	0
benztropine	low	2	0
lithium	low	1	0
4-hydroxy-2-nonenal	low	1	0
mdl 100907	low	1	0
fluvoxamine	low	1	0
desvenlafaxine succinate	low	1	0
paliperidone palmitate	low	4	0
betrixaban	low	1	0
brexpiprazole	low	1	0
valbenazine	medium	51	10
quetiapine fumarate	low	2	0
piperidines	low	1	0
plecanatide	low	1	0
clozapine	low	9	0
olanzapine	low	2	0

Protein Targets (846)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
acetylcholinesterase	13	0	0	13
thioredoxin reductase	20	0	0	20
RAR-related orphan receptor gamma	13	0	0	13
GLI family zinc finger 3	19	0	0	19
AR protein	24	0	0	24
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
progesterone receptor	11	0	0	11
glucocorticoid receptor [Homo sapiens]	21	0	0	21
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
retinoid X nuclear receptor alpha	11	0	0	11
estrogen-related nuclear receptor alpha	14	0	0	14
estrogen nuclear receptor alpha	22	0	0	22
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	28	0	0	28
aryl hydrocarbon receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	14	0	0	14
Histone H2A.x	5	0	0	5
Bloom syndrome protein isoform 1	10	0	0	10
hemoglobin subunit beta	1	0	0	1
chromobox protein homolog 1	11	0	0	11
heat shock protein beta-1	7	0	0	7
DNA polymerase iota isoform a (long)	7	0	0	7
geminin	19	0	0	19
muscarinic acetylcholine receptor M1	14	0	0	14
lamin isoform A-delta10	21	0	0	21
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Cellular tumor antigen p53	15	0	0	15
Delta-aminolevulinic acid dehydratase	0	1	0	1
Glutamate receptor 2	10	2	1	13
Isocitrate lyase 1	0	1	0	1
Isocitrate lyase	0	1	0	1
TAR DNA-binding protein 43	7	0	0	7
Isocitrate lyase	0	1	0	1
Microtubule-associated protein tau	11	0	0	11
vitamin D3 receptor isoform VDRA	9	0	0	9
Transient receptor potential cation channel subfamily A member 1	0	1	2	3
phosphopantetheinyl transferase	9	0	0	9
mu-type opioid receptor isoform MOR-1	0	0	2	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
5-hydroxytryptamine receptor 2A	0	0	2	2
Gamma-aminobutyric acid receptor subunit pi	10	6	1	17
Cytochrome P450 3A4	0	13	0	16
5-hydroxytryptamine receptor 1A	0	14	7	22
5-hydroxytryptamine receptor 2C	0	16	0	16
Neuronal acetylcholine receptor subunit alpha-4	1	4	3	9
Cytochrome P450 2C9	0	9	0	10
Neuronal acetylcholine receptor subunit beta-2	1	4	3	9
D(2) dopamine receptor	0	28	5	39
5-hydroxytryptamine receptor 2A	0	17	1	19
Gamma-aminobutyric acid receptor subunit beta-1	10	6	1	17
Alpha-1B adrenergic receptor	0	20	2	22
Translocator protein	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	10	6	1	17
Gamma-aminobutyric acid receptor subunit gamma-2	10	6	3	19
D	0	14	0	15
D(3) dopamine receptor	0	14	0	14
5-hydroxytryptamine receptor 1A	0	22	2	27
Alpha-2B adrenergic receptor	0	13	2	16
Gamma-aminobutyric acid receptor subunit alpha-5	10	6	1	17
Gamma-aminobutyric acid receptor subunit alpha-3	10	6	1	17
D(2) dopamine receptor	0	7	0	7
Alpha-2C adrenergic receptor	0	13	2	16
Alpha-2A adrenergic receptor	0	13	2	16
Gamma-aminobutyric acid receptor subunit gamma-1	10	6	1	17
Gamma-aminobutyric acid receptor subunit alpha-2	10	6	1	17
Alpha-1D adrenergic receptor	0	17	2	20
Sodium-dependent dopamine transporter	0	18	0	18
Alpha-1D adrenergic receptor	0	20	1	23
5-hydroxytryptamine receptor 1D	0	1	0	2
5-hydroxytryptamine receptor 1B	0	3	2	5
5-hydroxytryptamine receptor 2C	0	28	2	30
Gamma-aminobutyric acid receptor subunit alpha-4	10	6	1	17
Gamma-aminobutyric acid receptor subunit gamma-3	10	6	1	17
5-hydroxytryptamine receptor 1B	0	15	0	16
5-hydroxytryptamine receptor 1D	0	7	0	8
Gamma-aminobutyric acid receptor subunit alpha-6	10	6	1	17
5-hydroxytryptamine receptor 1F	0	7	0	8
5-hydroxytryptamine receptor 2B	0	15	1	16
Sodium-dependent serotonin transporter	0	14	1	15
5-hydroxytryptamine receptor 7	0	9	0	9
5-hydroxytryptamine receptor 7	0	11	1	12
Alpha-1A adrenergic receptor	0	9	2	13
Alpha-1B adrenergic receptor	0	6	1	9
5-hydroxytryptamine receptor 3A	0	8	0	8
Alpha-1A adrenergic receptor	0	20	2	22
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 6	0	18	1	20
5-hydroxytryptamine receptor 7	0	9	0	9
D(2) dopamine receptor	0	20	0	22
Gamma-aminobutyric acid receptor subunit alpha-1	10	6	3	19
Gamma-aminobutyric acid receptor subunit beta-3	10	6	1	17
Gamma-aminobutyric acid receptor subunit beta-2	10	6	3	19
D	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
GABA theta subunit	10	6	1	17
Sigma non-opioid intracellular receptor 1	0	23	0	23
Gamma-aminobutyric acid receptor subunit epsilon	10	6	1	17
5-hydroxytryptamine receptor 3B	0	8	0	8
Lysosomal alpha-glucosidase	0	1	0	1
Transporter	0	15	1	17
ATP-dependent phosphofructokinase	14	0	0	14
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Carbonic anhydrase 1	0	1	0	4
Carbonic anhydrase 2	0	1	0	4
Alanine racemase, biosynthetic	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	9	1	11
Proton-coupled amino acid transporter 1	0	2	0	2
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
NFKB1 protein, partial	10	0	0	10
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
thyroid stimulating hormone receptor	13	0	0	13
regulator of G-protein signaling 4	13	0	0	13
EWS/FLI fusion protein	15	0	0	15
putative alpha-glucosidase	1	0	0	1
thyroid hormone receptor beta isoform 2	17	0	0	17
peripheral myelin protein 22	16	0	0	16
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Solute carrier family 22 member 2	0	7	0	8
Solute carrier family 22 member 1	0	9	0	11
Glutamate receptor ionotropic, NMDA 2D	0	4	0	4
Glutamate receptor ionotropic, NMDA 3B	0	4	0	4
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Spike glycoprotein	20	2	3	25
Glutamate receptor ionotropic, NMDA 2A	0	8	1	10
Glutamate receptor ionotropic, NMDA 2B	0	8	1	10
Glutamate receptor ionotropic, NMDA 2C	0	8	1	11
Glutamate receptor ionotropic, NMDA 1	0	5	0	5
Glutamate receptor ionotropic, NMDA 2A	0	5	0	5
Glutamate receptor ionotropic, NMDA 2B	0	5	0	5
Glutamate receptor ionotropic, NMDA 2C	0	4	0	4
Glutamate receptor ionotropic, NMDA 2D	0	8	1	10
Solute carrier family 22 member 1	0	5	0	5
Glutamate receptor ionotropic, NMDA 3A	0	4	0	4
Glutamate receptor ionotropic, NMDA 3B	0	8	1	10
Multidrug and toxin extrusion protein 1	0	6	0	6
Solute carrier family 22 member 2	0	4	0	4
Glutamate receptor ionotropic, NMDA 3A	0	8	1	10
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
5-hydroxytryptamine receptor 3E	0	4	1	5
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
SMAD family member 2	4	0	0	4
Fumarate hydratase	12	0	0	12
USP1 protein, partial	8	0	0	8
PPM1D protein	4	0	0	4
SMAD family member 3	4	0	0	4
TDP1 protein	18	0	0	18
estrogen receptor 2 (ER beta)	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	10	0	0	10
G	10	0	0	10
cytochrome P450 2D6	20	0	0	20
polyprotein	12	0	0	12
67.9K protein	4	0	0	4
peroxisome proliferator-activated receptor delta	10	0	0	10
peroxisome proliferator activated receptor gamma	10	0	0	10
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
thyroid stimulating hormone receptor	11	0	0	11
lysosomal alpha-glucosidase preproprotein	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	15	0	0	15
transcriptional regulator ERG isoform 3	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	16	0	0	16
nuclear receptor ROR-gamma isoform 1	8	0	0	8
neuropeptide S receptor isoform A	4	0	0	4
ATP-binding cassette sub-family C member 3	0	20	0	20
Multidrug resistance-associated protein 4	0	20	0	20
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 3B	0	4	1	5
Bile salt export pump	0	26	0	26
Interferon beta	14	0	0	14
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
ATP-dependent translocase ABCB1	0	10	0	15
Alpha-2C adrenergic receptor	0	20	2	23
Muscarinic acetylcholine receptor M3	0	21	2	23
D(1A) dopamine receptor	0	15	1	19
D(4) dopamine receptor	0	12	1	18
D(1B) dopamine receptor	0	6	0	9
5-hydroxytryptamine receptor 2A	0	30	2	34
D(4) dopamine receptor	0	12	0	12
Histamine H1 receptor	0	5	0	5
Sodium-dependent serotonin transporter	0	30	2	32
Histamine H1 receptor	0	23	3	28
D(3) dopamine receptor	0	22	2	29
5-hydroxytryptamine receptor 2B	0	28	2	30
5-hydroxytryptamine receptor 3A	0	4	1	5
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Inositol monophosphatase 1	9	0	0	9
Potassium voltage-gated channel subfamily H member 2	0	34	0	34
5-hydroxytryptamine receptor 3D	0	4	1	5
Multidrug and toxin extrusion protein 2	0	5	0	5
5-hydroxytryptamine receptor 3C	0	4	1	5
Inositol hexakisphosphate kinase 1	10	0	0	10
Canalicular multispecific organic anion transporter 1	0	20	0	20
Histamine H3 receptor	0	8	0	8
cytochrome P450 2C9, partial	10	0	0	10
ATAD5 protein, partial	10	0	0	10
activating transcription factor 6	6	0	0	6
D(1A) dopamine receptor	18	0	0	18
cytochrome P450 3A4 isoform 1	10	0	0	10
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	18	0	0	18
Spike glycoprotein	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	8	0	0	8
Transmembrane protease serine 2	0	2	3	5
5-hydroxytryptamine receptor 4	0	22	0	22
Procathepsin L	0	3	3	6
Aldo-keto reductase family 1 member B1	0	18	0	18
Muscarinic acetylcholine receptor M2	0	18	3	22
Muscarinic acetylcholine receptor M4	0	18	1	19
Muscarinic acetylcholine receptor M1	0	8	1	9
Muscarinic acetylcholine receptor M5	0	17	0	17
Alpha-2A adrenergic receptor	0	20	2	23
Replicase polyprotein 1a	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Muscarinic acetylcholine receptor M2	0	8	1	9
Muscarinic acetylcholine receptor M1	0	19	3	23
Alpha-2B adrenergic receptor	0	18	1	20
Sodium-dependent noradrenaline transporter	0	25	2	27
Histamine H2 receptor	0	12	0	12
Histamine H2 receptor	9	2	0	13
Sodium-dependent dopamine transporter	0	18	1	19
Angiotensin-converting enzyme 2	0	2	3	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
cytochrome P450 2D6 isoform 1	12	0	0	12
survival motor neuron protein isoform d	9	0	0	9
Telomerase reverse transcriptase	0	1	0	1
Acetylcholinesterase	0	6	0	6
Lysine-specific histone demethylase 1A	0	1	0	1
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Cholinesterase	0	8	0	8
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	2
Acetylcholinesterase	0	8	3	12
Aldo-keto reductase family 1 member C3	0	1	0	1
Prolyl endopeptidase	0	2	0	2
Aldo-keto reductase family 1 member C2	0	1	0	1
Cholinesterase	0	6	0	6
Cytochrome P450 1B1	0	4	0	4
Prothrombin	0	1	1	2
Coagulation factor X	0	2	0	2
Plasminogen	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Vitamin K-dependent protein C	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	3	1	5
Cytochrome P450 2C11	0	1	0	1
Cytochrome P450 2D6	0	11	1	13
Cytochrome P450 2A6	0	3	1	4
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
Cannabinoid receptor 1	0	1	0	2
Cytochrome P450 3A7	0	1	0	1
Caspase-1	0	0	1	1
Cytochrome P450 2C19	0	3	0	5
Cannabinoid receptor 2	0	1	1	3
Mu-type opioid receptor	0	11	2	13
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Delta-type opioid receptor	0	7	1	8
Kappa-type opioid receptor	0	9	1	10
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	2	1	3
Transient receptor potential cation channel subfamily V member 2	0	2	1	3
G-protein coupled receptor 55	0	0	1	1
Diacylglycerol lipase-alpha	0	1	0	1
Chain A, serum paraoxonase	0	1	0	1
DNA polymerase kappa isoform 1	6	0	0	6
Carbonic anhydrase 12	0	1	0	2
Carbonic anhydrase 3	0	1	0	2
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase 13	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	5	0	0	5
Smad3	6	0	0	6
caspase 7, apoptosis-related cysteine protease	8	0	0	8
NADPH oxidase 1	0	2	0	2
Snq2p	0	0	0	3
caspase-3	8	0	0	8
IDH1	6	0	0	6
Adenylate cyclase type 1	0	4	0	4
Caspase-7	3	0	0	3
cellular tumor antigen p53 isoform a	3	0	0	3
caspase-3	3	0	0	3
histone deacetylase 9 isoform 3	1	0	0	1
mitogen-activated protein kinase 1	9	0	0	9
atrial natriuretic peptide receptor 2 precursor	7	0	0	7
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	9	0	0	9
M-phase phosphoprotein 8	8	0	0	8
lethal factor (plasmid)	6	0	0	6
Proteasome subunit alpha type-7	0	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	8	0	8
Bile salt export pump	0	4	0	4
Potassium channel subfamily K member 2	0	4	2	6
Epidermal growth factor receptor	0	3	0	3
Albumin	0	0	3	3
Albumin	0	0	5	5
Major prion protein	0	0	3	3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Major prion protein	0	0	1	1
Integrin beta-3	3	0	1	4
Tyrosine-protein kinase Fyn	0	3	0	3
Muscarinic acetylcholine receptor M3	0	7	1	8
Muscarinic acetylcholine receptor M4	0	7	1	8
Integrin alpha-IIb	3	0	1	4
Muscarinic acetylcholine receptor M5	0	7	1	8
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Angiotensin-converting enzyme	0	16	0	16
Sphingomyelin phosphodiesterase	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
Adenylate cyclase type 3	0	4	0	4
UDP-glucuronosyltransferase 1A4	0	0	0	5
D(1B) dopamine receptor	0	10	0	10
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	4	0	4
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	3	0	6
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 4 subunit alpha	0	5	0	6
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	7	1	0	8
Cytochrome P450 2J2	0	6	0	7
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	8	0	8
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Aldehyde oxidase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	8	0	8
Voltage-dependent L-type calcium channel subunit alpha-1C	0	10	0	10
Sodium channel protein type 5 subunit alpha	0	9	0	9
Sodium channel protein type 9 subunit alpha	0	6	0	6
Nuclear receptor subfamily 3 group C member 3	0	15	0	15
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
D	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	5	0	5
Proteasome subunit beta type-7	0	0	0	1
Ataxin-2	15	0	0	15
Sodium channel protein type 3 subunit alpha	0	5	0	5
Sodium channel protein type 11 subunit alpha	0	4	0	4
Sodium channel protein type 8 subunit alpha	0	4	0	4
Sodium channel protein type 10 subunit alpha	0	5	0	5
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
Sodium-dependent noradrenaline transporter	0	3	0	3
Tryptophan 5-hydroxylase 1	0	3	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Aromatase	0	1	0	1
Sigma intracellular receptor 2	0	4	0	4
Sodium-dependent serotonin transporter	0	3	0	3
Sodium-dependent dopamine transporter	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	9	0	9
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Translocator protein	0	1	0	1
Translocator protein	0	2	0	2
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Luciferase	2	0	0	2
GLS protein	13	0	0	13
Beta-1 adrenergic receptor	0	2	1	4
glucocerebrosidase	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
peripheral myelin protein 22 isoform 1	7	0	0	7
cytochrome P450 2C19 precursor	3	0	0	3
cytochrome P450 2C9 precursor	3	0	0	3
DNA polymerase beta	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
transient receptor potential cation channel subfamily V member 1	2	0	0	2
Beta-2 adrenergic receptor	0	6	0	7
Beta-1 adrenergic receptor	0	5	1	7
Endothelin receptor type B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	3	0	3
Endothelin receptor type B	0	1	0	1
Adenosine receptor A1	0	4	0	5
Beta-3 adrenergic receptor	0	4	0	4
Histamine H1 receptor	0	6	0	6
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 2A	0	3	0	3
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 4	0	2	0	2
Transporter	0	4	0	4
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
ATPase family AAA domain-containing protein 5	7	0	0	7
Histamine H4 receptor	0	2	1	3
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
15-lipoxygenase, partial	4	0	0	4
GALC protein	4	0	0	4
arylsulfatase A	11	0	0	11
huntingtin isoform 2	2	0	0	2
Solute carrier family 22 member 3	0	2	0	2
Solute carrier family 22 member 3	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 5B	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
5-hydroxytryptamine receptor 4	0	3	0	4
Histamine H3 receptor	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
Synaptic vesicular amine transporter	0	3	1	4
alpha-galactosidase	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
Retinoic acid receptor RXR-alpha	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Acetylcholinesterase	0	3	0	3
Amyloid-beta precursor protein	0	3	0	3
Amine oxidase [flavin-containing] B	0	3	0	3
Amine oxidase [flavin-containing] A	0	3	0	3
Amine oxidase [flavin-containing] A	0	3	0	3
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	2	0	2
Liver carboxylesterase 1	0	1	0	1
Acetylcholinesterase	0	3	0	3
Amine oxidase [flavin-containing] B	0	3	2	5
Choline O-acetyltransferase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Beta-secretase 1	0	1	0	1
Cholinesterase	0	2	0	2
Acetylcholine receptor subunit epsilon	0	1	2	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Carboxylic ester hydrolase	0	4	0	4
glp-1 receptor, partial	6	0	0	6
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Alpha-synuclein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
flap endonuclease 1	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
UDP-glucuronosyltransferase 1A9	0	1	0	4
UDP-glucuronosyltransferase 2B17	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
UDP-glucuronosyltransferase 1-6	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
UDP-glucuronosyltransferase 1A7	0	0	0	1
Chain A, Cruzipain	1	0	0	1
pregnane X receptor	2	0	0	2
Beta-2 adrenergic receptor	0	2	1	4
Adenosine receptor A3	0	3	1	4
Beta-3 adrenergic receptor	0	4	1	5
Androgen receptor	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Chain A, ACETYLCHOLINESTERASE	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Delta-type opioid receptor	0	2	0	3
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Kappa-type opioid receptor	0	2	0	2
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Chain A, Ferritin light chain	2	0	0	2
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
thyroid hormone receptor beta isoform a	4	0	0	4
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	1	0	1
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	2	2	1	5
Glutamate receptor 3	2	2	1	5
Glutamate receptor 4	2	2	1	5
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
nonstructural protein 1	1	0	0	1
Cocaine esterase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
C-8 sterol isomerase	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	2	0	2
endonuclease IV	2	0	0	2
hypothetical protein, conserved	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
Envelope glycoprotein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
dopamine D1 receptor	1	0	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
apical membrane antigen 1, AMA1	2	0	0	2
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
glucokinase regulatory protein	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Polyphenol oxidase 2	0	0	0	1
Plasma kallikrein	0	0	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosinase	0	1	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
phosphoglycerate kinase	1	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-3	0	2	3	6
Acetylcholine receptor subunit gamma	0	2	2	4
Acetylcholine receptor subunit beta	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-2	0	2	3	6
Neuronal acetylcholine receptor subunit beta-3	0	2	3	6
Neuronal acetylcholine receptor subunit beta-4	0	2	3	6
Neuronal acetylcholine receptor subunit beta-2	0	3	1	5
Neuronal acetylcholine receptor subunit alpha-5	0	2	3	6
Neuronal acetylcholine receptor subunit beta-4	0	3	1	5
Neuronal acetylcholine receptor subunit alpha-3	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-7	0	3	2	5
Neuronal acetylcholine receptor subunit alpha-6	0	2	3	6
Neuronal acetylcholine receptor subunit alpha-9	0	2	3	6
Neuronal acetylcholine receptor subunit alpha-4	0	3	1	5
Neuronal acetylcholine receptor subunit alpha-7	0	2	3	6
Acetylcholine receptor subunit delta	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-10	0	2	3	6
Myeloperoxidase	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Aromatase	0	1	0	1
G protein-activated inward rectifier potassium channel 2	0	0	1	1
G protein-activated inward rectifier potassium channel 4	0	0	1	1
G protein-activated inward rectifier potassium channel 1	0	0	1	1
Heparanase	0	0	1	1
interleukin 8	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Muscarinic acetylcholine receptor M4	0	1	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Nuclear receptor ROR-gamma	2	0	0	2
Acetylcholine-binding protein	0	1	1	2
Mu-type opioid receptor	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
DNA repair protein RAD52 homolog	0	1	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Kappa-type opioid receptor	0	0	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Mu-type opioid receptor	0	0	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Chain A, Beta-lactamase	2	0	0	2
DNA polymerase III, partial	1	0	0	1
XBP1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	1	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	2	2
WD repeat-containing protein 48	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
Cytochrome P450 2C8	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Renin	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
hexokinase	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (163)

Protein Targets (846)

Tardive Dyskinesia

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (163)

Drugs Studied (75)

Protein Targets (846)