A-alphalipoprotein Neuropathy

An autosomal recessively inherited disorder caused by mutation of ATP-BINDING CASSETTE TRANSPORTERS involved in cellular cholesterol removal (reverse-cholesterol transport). It is characterized by near absence of ALPHA-LIPOPROTEINS (high-density lipoproteins) in blood. The massive tissue deposition of cholesterol esters results in HEPATOMEGALY; SPLENOMEGALY; RETINITIS PIGMENTOSA; large orange tonsils; and often sensory POLYNEUROPATHY. The disorder was first found among inhabitants of Tangier Island in the Chesapeake Bay, MD.

Synonym
A-alphalipoprotein Neuropathy
High Density Lipoprotein Deficiency, Type 1
High-Density Lipoprotein Deficiency, Tangier Type
HDLDT1
Analphalipoproteinemia
Cholesterol Thesaurismosis
High-Density Lipoprotein Deficiency, Type I
Alpha High Density Lipoprotein Deficiency Disease
Tangier Hereditary Neuropathy
Tangier Disease Neuropathy
Tangier Disease
High Density Lipoprotein Deficiency, Tangier Type
Neuropathy of Tangier Disease

Excerpt	Reference
"Tangier disease is a rare autosomal recessive lipid transport disease characterized by the absence of the usual high density lipoproteins from plasma and cholesteryl ester storage in many organs."	( Assmann, G, 1979)
"Tangier disease is a rare genetic disorder characterized by extremely low plasma levels of HDL and apo A-I, deposition of cholesteryl esters in tissues, and a high prevalence of cardiovascular disease."	( Francis, GA; Knopp, RH; Oram, JF, 1995)
"Tangier disease is characterized by HDL hypercatabolism and increased deposition of cholesterol in tissues."	( Brewer, HB; Farsi, BD; Nazih, H; Remaley, AT; Schumacher, UK; Stonik, JA, 1997)
"Tangier disease is an inherited disorder that results in a deficiency in circulating levels of HDL."	( Fan, X; Halleck, MS; Krahling, S; Malowitz, J; Ng, S; Remaley, AT; Schlegel, RA; Williamson, P, 2007)
"Tangier disease is one of the most severe forms of familial high-density lipoprotein (HDL) deficiency."	( Bigazzi, F; Puntoni, M; Sampietro, T; Sbrana, F, 2012)
"Tangier disease is an autosomal recessive disorder caused by mutations in the ABCA1 gene and characterized by the accumulation of cholesteryl ester in various tissues and a near absence of high-density lipoprotein."	( Capalbo, M; Giardina, E; Parri, G; Sechi, A; Stocchi, L; Vagnini, A; Valentini, M; Varriale, L, 2018)

Excerpt	Reference
"25 cases of Tangier disease have been described so long."	( Assmann, G, 1979)

Excerpt	Reference
"Finally, treatment of Tangier disease plasma with DMPC affected the amount of neither prebeta(1)-LpA-I nor free cholesterol efflux."	( Blain, S; Boucher, B; Denis, M; Genest, J; Hajj Hassan, H; Krimbou, L, 2005)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	67 (28.88)	23.3326
1990's	47 (20.26)	12.5806
2000's	89 (38.36)	18.1394
2010's	27 (11.64)	28.8240
2020's	2 (0.86)	9.53

Drug	Relationship Strength	Studies	Trials
1-butanol	low	1	0
choline	low	1	0
glycine	low	1	0
nickel	low	1	0
niacin	low	2	0
nitrous oxide	low	1	0
phosphorylcholine	low	1	0
uric acid	low	1	0
1-anilino-8-naphthalenesulfonate	low	5	0
phenytoin	low	1	0
clofibrate	low	2	0
fentanyl	low	1	0
gemfibrozil	low	4	0
glyburide	low	5	0
guanidine	low	1	0
isoflurane	low	1	0
midazolam	low	1	0
pd 98059	low	1	0
probucol	low	4	0
propofol	low	1	0
propranolol	low	1	0
glutamine	low	1	0
sucrose	low	1	0
adenosine diphosphate	low	3	0
leucine	low	1	0
1,2-dipalmitoylphosphatidylcholine	low	1	0
egtazic acid	low	1	0
arginine	low	5	0
pantothenic acid	low	1	0
taurocholic acid	low	1	0
potassium cyanide	low	1	0
cyclopentane	low	2	0
perfluorooctanoic acid	low	1	0
malondialdehyde	low	1	0
d-alpha tocopherol	low	2	0
gold	low	1	0
deuterium	low	1	0
sodium selenite	low	1	0
4-chloro-7-nitrobenzofurazan	low	1	0
phytanic acid	low	1	0
tetradecanoylphorbol acetate	low	1	0
1-deoxynojirimycin	low	1	0
8-bromo cyclic adenosine monophosphate	low	4	0
transferrin	low	2	0
bezafibrate	low	1	0
vecuronium bromide	low	1	0
desflurane	low	1	0
colforsin	low	1	0
miglustat	low	1	0
lovastatin	low	1	0
sudan black b	low	1	0
fat red 7b	low	1	0
colestipol	low	1	0
trazodone hydrochloride	low	1	0
glucose, (beta-d)-isomer	low	1	0
mevastatin	low	1	0
methacycline	low	2	0
oxazolidin-2-one	low	1	0
fibrinogen	medium	2	1
u 73122	low	1	0
22-hydroxycholesterol	low	4	0
1-hexadecyl-2-acetyl-glycero-3-phosphocholine	low	2	0
dodecyl-beta-d-maltoside	low	1	0
caprylates	low	1	0
1-leucine-4-nitroanilide	low	1	0
glycerophosphoinositol 4,5-bisphosphate	low	1	0
dexpanthenol	low	1	0
mevalonic acid	low	1	0
betadex	low	1	0
tretinoin	low	4	0
arachidonic acid	low	1	0
thapsigargin	low	1	0
geranylgeranyl pyrophosphate	low	1	0
t0901317	low	1	0
alitretinoin	low	4	0
h 89	low	1	0
quinine	low	1	0
d 609	low	1	0
sphingosine	low	1	0
psychosine	low	1	0
thromboxane a2	low	1	0
thromboxane b2	low	2	0
brefeldin a	low	2	0
lysophosphatidylcholines	low	1	0
dimyristoylphosphatidylcholine	low	2	0
cysteine	low	2	0
succinyl-trialanine-4-nitroanilide	low	1	0
selenium	low	1	0
1-palmitoyl-2-oleoylphosphatidylcholine	low	2	0
sphingosine phosphorylcholine	low	1	0
dalcetrapib	medium	2	1
2-hexyl-1-cyclopentanone thiosemicarbazone	low	1	0
u 18666a	low	1	0
ucn 1028 c	low	1	0
anacetrapib	low	1	0
calcimycin	low	1	0
phytosterols	low	2	0
c-peptide	low	1	0
phosphatidylcholines	medium	15	1
aramchol	low	1	0
psychosine-3'-sulfate ester	low	1	0
glycolipids	low	6	0
interleukin-8	low	1	0
methylcellulose	low	1	0
epidermal growth factor	low	1	0
cyclosporine	low	1	0
thromboplastin	low	1	0
guanosine triphosphate	low	1	0
cholestyramine resin	low	1	0
filipin	low	1	0

Protein Targets (877)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	4	0	0	4
thioredoxin reductase	14	0	0	14
USP1 protein, partial	12	0	0	12
TDP1 protein	24	0	0	24
vitamin D3 receptor isoform VDRA	10	0	0	10
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	6	0	0	6
serine/threonine-protein kinase PLK1	2	0	0	2
snurportin-1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	8	0	0	8
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	15	0	0	15
DNA polymerase kappa isoform 1	6	0	0	6
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	2	0	2
Transthyretin	0	0	2	2
Fatty acid-binding protein, intestinal	0	2	1	3
Fatty acid-binding protein, adipocyte	0	2	2	4
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Fatty acid-binding protein 5	0	1	1	2
Fatty acid-binding protein 5	0	0	2	2
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
aldehyde dehydrogenase 1 family, member A1	16	0	0	16
glucocorticoid receptor [Homo sapiens]	10	0	0	10
farnesoid X nuclear receptor	9	0	0	9
estrogen nuclear receptor alpha	22	0	0	22
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Cellular tumor antigen p53	9	0	0	9
Glutamate receptor 2	5	0	0	5
Choline O-acetyltransferase	0	1	0	3
glucocerebrosidase	4	0	0	4
Alpha-mannosidase	0	1	0	1
alpha-galactosidase	3	0	0	3
Trehalase	0	2	0	2
lysosomal alpha-glucosidase preproprotein	3	0	0	3
Trehalase	0	1	0	1
Maltase-glucoamylase, intestinal	0	2	0	2
Trehalase	0	2	0	2
Lysosomal acid glucosylceramidase	0	4	0	4
Alpha-galactosidase A	0	1	0	1
Alpha-glucosidase MAL62	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Lysosomal alpha-glucosidase	0	4	0	4
Beta-glucosidase A	0	1	0	1
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1B adrenergic receptor	0	4	1	5
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1D adrenergic receptor	0	3	1	4
Beta-glucosidase	0	1	0	1
Protein-lysine 6-oxidase	0	4	0	4
Alpha-mannosidase 2	0	2	0	2
Glycogen debranching enzyme	0	2	0	2
Glycogen debranching enzyme	0	1	0	1
Alpha-glucosidase MAL32	0	2	0	2
Alpha-1A adrenergic receptor	0	4	1	5
Oligo-1,6-glucosidase IMA1	0	1	0	1
Alpha-glucosidase MAL12	0	2	0	2
Oxysterols receptor LXR-beta	0	3	3	6
Spike glycoprotein	4	0	0	4
Alpha-amylase	0	1	0	1
Trehalose synthase/amylase TreS	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Oxysterols receptor LXR-alpha	0	3	3	6
Neutral alpha-glucosidase AB	0	2	0	2
Ceramide glucosyltransferase	0	2	0	2
Lysosomal acid glucosylceramidase	0	1	0	1
Probable maltase-glucoamylase 2	0	1	0	1
Beta-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	2	0	2
Cytosolic beta-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	2	0	2
Putative alpha-glucosidase	0	2	0	2
Chain A, Cruzipain	7	0	0	7
regulator of G-protein signaling 4	8	0	0	8
Platelet-activating factor receptor	0	2	0	2
Inositol monophosphatase 1	6	0	0	6
NPYLR7B	0	0	1	1
Replicase polyprotein 1ab	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	2	3
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	3	3	6
Delta-type opioid receptor	0	3	2	5
Kappa-type opioid receptor	0	3	2	5
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Chain A, Ferritin light chain	11	0	0	11
Luciferase	8	0	0	8
acetylcholinesterase	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	12	0	0	12
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
GLI family zinc finger 3	12	0	0	12
Microtubule-associated protein tau	14	0	0	14
AR protein	19	0	0	19
estrogen receptor 2 (ER beta)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
progesterone receptor	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	13	0	0	13
retinoid X nuclear receptor alpha	11	0	0	11
estrogen-related nuclear receptor alpha	18	0	0	18
pregnane X nuclear receptor	14	0	0	14
peroxisome proliferator-activated receptor delta	8	0	0	8
peroxisome proliferator activated receptor gamma	9	0	0	9
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
thyroid stimulating hormone receptor	5	0	0	5
Histone H2A.x	2	0	0	2
retinoic acid receptor alpha isoform 1	0	1	0	1
thyroid hormone receptor beta isoform 2	9	0	0	9
retinoic acid receptor RXR-alpha isoform a	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
nuclear receptor ROR-gamma isoform 1	12	0	0	12
Renin	0	0	1	1
Cytochrome P450 1A2	0	2	1	3
Retinoic acid receptor alpha	0	4	4	12
Retinoic acid receptor beta	0	4	4	12
Retinoic acid receptor alpha	0	2	3	5
Retinoic acid receptor gamma	0	4	4	12
Retinoic acid receptor gamma	0	1	3	4
Retinoic acid receptor RXR-alpha	0	5	5	12
Retinoic acid receptor beta	0	1	3	4
Nuclear receptor subfamily 4 group A member 1	0	0	1	1
Cellular retinoic acid-binding protein 2	0	0	2	2
Retinoic acid receptor RXR-alpha	0	2	4	6
Retinoic acid receptor RXR-beta	0	4	4	8
Retinoic acid receptor RXR-beta	0	1	4	5
Retinoic acid receptor RXR-gamma	0	1	4	5
Type-1 angiotensin II receptor	0	0	1	1
Cellular retinoic acid-binding protein 1	0	2	0	3
Retinoic acid receptor RXR-gamma	0	4	4	8
Type-2 angiotensin II receptor	0	0	1	1
Nuclear receptor ROR-gamma	1	3	3	7
Cellular retinoic acid-binding protein 1	0	0	2	2
Retinoic acid receptor RXR-alpha	0	0	1	1
EWS/FLI fusion protein	7	0	0	7
Nuclear receptor subfamily 1 group I member 2	0	1	4	5
Cholesteryl ester transfer protein	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Beta-lactamase	6	0	0	6
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
15-lipoxygenase, partial	4	0	0	4
phosphopantetheinyl transferase	9	0	0	9
thioredoxin glutathione reductase	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	6	0	0	6
Bloom syndrome protein isoform 1	11	0	0	11
cellular tumor antigen p53 isoform a	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
cytochrome P450 3A4 isoform 1	7	0	0	7
histone acetyltransferase KAT2A isoform 1	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
lamin isoform A-delta10	9	0	0	9
Fatty-acid amide hydrolase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	7	4	2	13
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Prostaglandin G/H synthase 1	0	0	0	1
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Aromatase	0	1	0	1
Tissue factor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	7	4	2	13
Gamma-aminobutyric acid receptor subunit delta	7	4	2	13
Gamma-aminobutyric acid receptor subunit gamma-2	7	4	2	13
Gamma-aminobutyric acid receptor subunit alpha-5	7	4	2	13
Gamma-aminobutyric acid receptor subunit alpha-3	7	4	2	13
Gamma-aminobutyric acid receptor subunit gamma-1	7	4	2	13
Gamma-aminobutyric acid receptor subunit alpha-2	7	4	2	13
Gamma-aminobutyric acid receptor subunit alpha-4	7	4	2	13
Gamma-aminobutyric acid receptor subunit gamma-3	7	4	2	13
Gamma-aminobutyric acid receptor subunit alpha-6	7	4	2	13
Prostaglandin G/H synthase 2	0	2	1	4
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Histamine H2 receptor	5	0	0	5
10 kDa heat shock protein, mitochondrial	0	2	0	2
Calmodulin	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	4	2	13
Gamma-aminobutyric acid receptor subunit beta-3	7	4	2	13
Gamma-aminobutyric acid receptor subunit beta-2	7	4	2	13
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Prostaglandin G/H synthase 2	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
GABA theta subunit	7	4	2	13
Gamma-aminobutyric acid receptor subunit epsilon	7	4	2	13
Solute carrier organic anion transporter family member 1B3	0	3	0	4
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	5	0	6
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	1	0	0	1
GLS protein	9	0	0	9
thyroid stimulating hormone receptor	9	0	0	9
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	13	0	0	13
muscarinic acetylcholine receptor M1	7	0	0	7
lethal factor (plasmid)	3	0	0	3
Cytochrome P450 3A4	0	3	2	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	11	0	0	11
Chain A, D-MALTODEXTRIN BINDING PROTEIN	0	0	1	1
Chain A, Limit Dextrinase	0	0	1	1
Chain A, Solute-binding protein	0	0	1	1
Chain A, Solute-binding protein	0	0	1	1
Chain B, SusD	0	0	1	1
Chain A, SusD	0	0	1	1
Chain A, SusD	0	0	1	1
Chain A, Alpha-hemolysin	0	0	1	1
Chain B, Alpha-hemolysin	0	0	1	1
Chain C, Alpha-hemolysin	0	0	1	1
Chain D, Alpha-hemolysin	0	0	1	1
Chain E, Alpha-hemolysin	0	0	1	1
Chain F, Alpha-hemolysin	0	0	1	1
Chain G, Alpha-hemolysin	0	0	1	1
activating transcription factor 6	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
G	9	0	0	9
D(1A) dopamine receptor	7	0	0	7
survival motor neuron protein isoform d	9	0	0	9
Glutamate receptor ionotropic, NMDA 2D	0	0	1	1
Glutamate receptor ionotropic, NMDA 3B	0	0	1	1
Bile salt export pump	0	4	0	5
5-hydroxytryptamine receptor 4	0	4	2	6
Bile salt export pump	0	16	0	17
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Fatty acid-binding protein, liver	0	4	1	5
Muscarinic acetylcholine receptor M1	0	0	2	2
Muscarinic acetylcholine receptor M3	0	0	2	2
Muscarinic acetylcholine receptor M4	0	0	2	2
Muscarinic acetylcholine receptor M5	0	0	2	2
Muscarinic acetylcholine receptor M2	0	0	2	2
Peroxisome proliferator-activated receptor alpha	0	0	2	2
Peroxisome proliferator-activated receptor delta	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	3	4
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Peroxisome proliferator-activated receptor delta	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	0	1	1
Peroxisome proliferator-activated receptor alpha	0	0	3	3
Glutamate receptor ionotropic, NMDA 2A	0	0	1	1
Glutamate receptor ionotropic, NMDA 2B	0	0	1	1
Glutamate receptor ionotropic, NMDA 2C	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	0	1	1
Inositol hexakisphosphate kinase 1	9	0	0	9
cytochrome P450 2C9, partial	9	0	0	9
PAX8	0	0	0	1
ATAD5 protein, partial	6	0	0	6
Smad3	6	0	0	6
67.9K protein	7	0	0	7
IDH1	6	0	0	6
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
major prion protein preproprotein Prp precursor	0	1	0	1
nuclear receptor subfamily 0 group B member 1	0	2	0	2
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
ras-related protein Rab-9A	4	0	0	4
steroidogenic factor 1	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
endonuclease IV	5	0	0	5
glp-1 receptor, partial	4	0	0	4
ClpP	1	0	0	1
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
Fumarate hydratase	3	0	0	3
TSHR protein	1	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
nonstructural protein 1	4	0	0	4
polyprotein	3	0	0	3
Parkin	8	0	0	8
arylsulfatase A	7	0	0	7
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
serine-protein kinase ATM isoform a	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	7	0	0	7
type-1 angiotensin II receptor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
glucokinase regulatory protein	1	0	0	1
huntingtin isoform 2	2	0	0	2
mitogen-activated protein kinase 1	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
apelin receptor	0	2	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
Vpr	2	0	0	2
streptokinase A precursor	0	0	2	2
neuropeptide S receptor isoform A	2	0	0	2
Rap guanine nucleotide exchange factor 3	4	0	0	4
Amyloid-beta precursor protein	1	2	0	3
Alpha-synuclein	3	1	0	4
D(1A) dopamine receptor	3	0	0	3
TAR DNA-binding protein 43	3	0	0	3
Ataxin-2	7	0	0	7
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Beta-lactoglobulin	0	0	1	1
Chain A, Beta-lactoglobulin	0	0	1	1
UDP-3-O-acyl-N-acetylglucosamine deacetylase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	2	0	4
Solute carrier family 22 member 1	0	5	0	6
Solute carrier family 22 member 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	5	0	8
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	5	0	7
GALC protein	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
M-phase phosphoprotein 8	3	0	0	3
ATP-binding cassette sub-family C member 3	0	10	0	10
Multidrug resistance-associated protein 4	0	11	0	11
Canalicular multispecific organic anion transporter 1	0	7	0	7
pregnane X receptor	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
aryl hydrocarbon receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
peripheral myelin protein 22	6	0	0	6
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
ATP-dependent translocase ABCB1	0	8	0	9
5-hydroxytryptamine receptor 1A	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 1	0	0	1	1
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Adenylate cyclase type 1	0	1	1	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Carbonic anhydrase 12	0	1	0	1
Carbonic anhydrase 1	0	2	0	3
Carbonic anhydrase 2	0	3	1	5
Cruzipain	0	1	0	1
Carbonic anhydrase 9	0	2	1	3
Phosphatidylcholine:ceramide cholinephosphotransferase 2	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
heat shock protein beta-1	4	0	0	4
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
D(2) dopamine receptor	0	2	1	3
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	1	0	1
Histamine H1 receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	1	0	1
interleukin 8	1	0	0	1
cytochrome P450 2C9 precursor	4	0	0	4
histone deacetylase 9 isoform 3	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
Cytochrome P450 2C8	0	2	0	2
Cannabinoid receptor 2	0	0	1	1
Guanylate cyclase soluble subunit alpha-1	0	0	1	1
Guanylate cyclase soluble subunit beta-1	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Amino acid transporter	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
cytochrome P450 2D6	6	0	0	6
cytochrome P450 2D6 isoform 1	2	0	0	2
Solute carrier family 22 member 6	0	2	0	2
ATP-binding cassette sub-family C member 9	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	2
Potassium channel subfamily K member 2	0	1	1	2
Chymotrypsinogen A	0	1	0	1
ATP synthase subunit beta, mitochondrial	0	1	0	1
ATP synthase subunit delta, mitochondrial	0	1	0	1
ATP synthase subunit gamma, mitochondrial	0	1	0	1
ATP synthase subunit epsilon, mitochondrial	0	1	0	1
Cytochrome P450 2C9	0	5	2	7
Cystic fibrosis transmembrane conductance regulator	0	1	0	1
5-hydroxytryptamine receptor 1A	0	6	1	8
Cholesteryl ester transfer protein	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
ATP-binding cassette sub-family C member 8	0	1	0	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	3
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	3
Glutamate receptor ionotropic, NMDA 2B	0	2	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	1	3
Large neutral amino acids transporter small subunit 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	1	3
Proton-coupled amino acid transporter 1	0	2	0	3
Glutamate receptor ionotropic, NMDA 3B	0	2	1	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	3
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Chain A, Uracil Phosphoribosyltransferase	0	0	1	1
Chain B, Uracil Phosphoribosyltransferase	0	0	1	1
Chain C, Uracil Phosphoribosyltransferase	0	0	1	1
Ras-related protein Rab-7a	0	0	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	0	2	0	2
Chain E, C-amp-dependent Protein Kinase	0	1	0	1
Chain I, Protein Kinase Inhibitor Peptide	0	1	0	1
Chain E, C-amp-dependent Protein Kinase	0	1	0	1
Chain E, C-amp-dependent Protein Kinase	0	1	0	1
Chain I, Protein Kinase Inhibitor Peptide	0	1	0	1
Rho-associated protein kinase 2	0	1	1	2
Ribosomal protein S6 kinase alpha-5	0	1	0	1
Serine/threonine-protein kinase D3	0	1	1	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	2	0	2
Protein kinase C gamma type	0	2	1	3
cAMP-dependent protein kinase catalytic subunit beta	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	1	2
Protein kinase C beta type	0	2	1	3
Myosin light chain kinase, smooth muscle	0	1	0	1
Protein kinase C alpha type	0	2	1	3
cAMP-dependent protein kinase catalytic subunit alpha	0	2	0	2
Casein kinase II subunit alpha'	0	1	0	1
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	0	1
Ribosomal protein S6 kinase beta-1	0	1	0	1
Protein kinase C eta type	0	1	1	2
cAMP-dependent protein kinase type II-beta regulatory subunit	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	2	0	2
RAC-beta serine/threonine-protein kinase	0	1	0	1
Protein kinase C iota type	0	1	1	2
G protein-coupled receptor kinase 6	0	1	0	1
Casein kinase I isoform alpha	0	1	0	1
Casein kinase I isoform delta	0	1	0	1
Casein kinase I isoform epsilon	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Casein kinase I isoform gamma-2	0	1	0	1
MO15-related protein kinase Pfmrk	0	1	0	1
Protein kinase C epsilon type	0	2	1	3
Protein kinase C theta type	0	1	1	2
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	2	1	3
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	1	0	1
cGMP-dependent protein kinase 1	0	1	0	1
Serine/threonine-protein kinase D1	0	1	1	2
Myosin light chain kinase, smooth muscle	0	1	0	1
Myosin light chain kinase 3	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	1	0	1
Casein kinase I isoform gamma-1	0	1	0	1
RAC-gamma serine/threonine-protein kinase	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, Antigen Cd11a (p180)	0	1	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
PINK1	3	0	0	3
isocitrate dehydrogenase 1, partial	1	0	0	1
caspase-3	2	0	0	2
thyrotropin-releasing hormone receptor	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
bcl-2-related protein A1	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Integrin beta-2	0	1	0	1
Intercellular adhesion molecule 1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Neutrophil elastase	0	1	0	1
Insulin receptor	0	2	0	2
Androgen receptor	0	2	0	2
Integrin alpha-L	0	1	1	2
Substance-K receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	4	0	4
Adenosine receptor A1	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	3	0	3
Sodium-dependent dopamine transporter	0	2	0	2
Histone deacetylase 1	0	1	0	1
Rap guanine nucleotide exchange factor 4	3	0	0	3
Histone deacetylase 2	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Histone deacetylase 6	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Translocator protein	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sucrase-isomaltase	0	1	0	1
Ceramide glucosyltransferase	0	1	0	1
Beta-galactosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
Polyphenol oxidase 2	0	2	0	2
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
Multidrug and toxin extrusion protein 1	0	2	0	2
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
Thrombopoietin	1	0	0	1
pyruvate kinase	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
pyruvate kinase PKM isoform b	1	0	0	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Luciferin 4-monooxygenase	0	1	1	2
Ornithine decarboxylase	1	0	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Mitogen-activated protein kinase 3	0	0	0	1
Mitogen-activated protein kinase 1	0	2	0	2
Dual specificity mitogen-activated protein kinase kinase 2	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	1	0	1
Gamma-aminobutyric acid	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Vascular cell adhesion protein 1	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	1	5
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
5-hydroxytryptamine receptor 2B	0	6	1	7
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Albumin	0	0	2	2
Beta-2 adrenergic receptor	0	2	1	3
Muscarinic acetylcholine receptor M2	0	1	1	2
Beta-1 adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	1	2	4
Adenosine receptor A3	0	3	1	4
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2D6	0	3	1	4
Muscarinic acetylcholine receptor M1	0	1	1	2
Beta-3 adrenergic receptor	0	2	1	3
Alpha-2B adrenergic receptor	0	0	1	2
Beta-1 adrenergic receptor	0	3	1	5
Alpha-2C adrenergic receptor	0	1	2	4
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Muscarinic acetylcholine receptor M3	0	1	1	2
D(1A) dopamine receptor	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Alpha-1D adrenergic receptor	0	0	1	2
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	1	2
Cytochrome P450 2C19	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 6	0	2	1	3
5-hydroxytryptamine receptor 7	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	3
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Solute carrier organic anion transporter family member 1A4	0	3	0	4
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	3
Cytochrome P450 2D4	0	1	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
DNA polymerase beta	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
eyes absent homolog 2 isoform a	1	0	0	1
C-terminal-binding protein 1	1	0	0	1
Chain A, Oxysterols receptor LXR-beta	0	1	0	1
Chain A, Oxysterols receptor LXR-beta	0	1	0	1
interferon gamma precursor	0	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Plasma kallikrein	0	0	1	1
Nuclear receptor ROR-alpha	0	3	1	4
Presenilin-1	0	1	1	2
Presenilin-2	0	1	1	2
Oxysterols receptor LXR-beta	0	0	1	1
Oxysterols receptor LXR-beta	0	0	1	1
Gamma-secretase subunit APH-1B	0	1	1	2
Nicastrin	0	1	1	2
Nuclear receptor ROR-beta	0	2	1	3
Gamma-secretase subunit APH-1A	0	1	1	2
Bile acid receptor	0	1	1	2
Gamma-secretase subunit PEN-2	0	1	1	2
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
ATP-binding cassette sub-family C member 3	0	0	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Ileal sodium/bile acid cotransporter	0	1	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Bile salt export pump	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Ras guanyl-releasing protein 3	0	0	1	1
PPM1D protein	1	0	0	1
DNA polymerase III, partial	1	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	1	2
Solute carrier organic anion transporter family member 2A1	0	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Telomerase reverse transcriptase	0	1	0	1
Cadherin-1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Adenomatous polyposis coli protein	0	1	0	1
Catenin beta-1	0	2	0	2
Tyrosine-protein kinase SYK	0	1	0	1
Transcription factor 7-like 2	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

A-alphalipoprotein Neuropathy

Synonyms(13)

Research Excerpts

Overview

Context

Treatment

Research

Studies (232)

Protein Targets (877)

A-alphalipoprotein Neuropathy

Synonyms(13)

Research Excerpts

Overview

Context

Treatment

Research

Studies (232)

Drugs Studied (121)

Protein Targets (877)