Page last updated: 2024-08-08 00:04:12

Potassium voltage-gated channel subfamily H member 5

A voltage-gated potassium channel KCNH5 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8NCM2]

Synonyms

Ether-a-go-go potassium channel 2;
hEAG2;
Voltage-gated potassium channel subunit Kv10.2

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Compounds (1)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamideHomo sapiens (human)IC5054,954,100,000.000011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
voltage-gated potassium channel activitymolecular functionEnables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]
calmodulin bindingmolecular functionBinding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
transmembrane transporter bindingmolecular functionBinding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]
protein-containing complex bindingmolecular functionBinding to a macromolecular complex. [GOC:jl]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surfacecellular componentThe external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
voltage-gated potassium channel complexcellular componentA protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah]

Involved In

This protein is involved in 2 target(s):

TargetCategoryDefinition
potassium ion transmembrane transportbiological processA process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]
regulation of membrane potentialbiological processAny process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]