Assay ID | Title | Year | Journal | Article |
AID4574 | Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor. | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID404707 | Selectivity for human 5HT1D receptor over human 5HT1B receptor | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide. |
AID18396 | Oral bioavailability in rat | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. |
AID4597 | Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID234716 | Relative efficacy in stimulation of [35S]GTP-gamma-S, binding in CHO cells compared to 5-HT | 1999 | Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4
| 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents. |
AID4602 | Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells | 1998 | Journal of medicinal chemistry, Jul-16, Volume: 41, Issue:15
| Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles. |
AID4582 | Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. |
AID6358 | Compound was evaluated for the affinity at 5-hydroxytryptamine 3 receptor | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID404703 | Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide. |
AID4590 | Percent efficacy relative to 5-HT treatment of CHO cells expressing 5-HT 1d receptor | 1998 | Journal of medicinal chemistry, Jul-16, Volume: 41, Issue:15
| Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles. |
AID4579 | Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor. | 1999 | Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4
| 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents. |
AID4587 | Efficacy was evaluated relative to human 5-hydroxytryptamine 1D receptor using [35S]GTP-gamma-S, as radioligand | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. |
AID4505 | Efficacy of compound was evaluated relative to human 5-hydroxytryptamine 1B receptor using [35S]GTP-gamma-S, as radioligand | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. |
AID4638 | Selectivity towards 5-HT1D and to that of 5-HT1B in CHO cells | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. |
AID4510 | Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID5956 | Compound was evaluated for the affinity at 5-hydroxytryptamine 2C receptor | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID4970 | Compound was evaluated for the affinity at 5-hydroxytryptamine 1E receptor | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID233219 | Relative binding to serotonin 5-HT 1B and 5-HT 1D receptors | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID4604 | Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. |
AID4595 | Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID45060 | Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor | 1998 | Journal of medicinal chemistry, Jul-16, Volume: 41, Issue:15
| Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles. |
AID4603 | Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells | 1999 | Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4
| 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents. |
AID4588 | Maximum stimulation of [35S]GTP-gamma-S, binding expressed relative to the maximal effect produced by 5-hydroxytryptamine 1D receptor. | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID4516 | Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells. | 1999 | Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4
| 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents. |
AID4977 | Compound was evaluated for the affinity at 5-hydroxytryptamine 1F receptor | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID5366 | Compound was evaluated for the affinity at 5-hydroxytryptamine 2A receptor | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID4512 | Compound was evaluated for the affinity at 5-hydroxytryptamine 1B receptor | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID233043 | Relative binding to serotonin 5-HT1D and 5-HT1B receptors | 1998 | Journal of medicinal chemistry, Jul-16, Volume: 41, Issue:15
| Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles. |
AID4460 | Compound was evaluated for the affinity at 5-hydroxytryptamine 1A receptor | 1997 | Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
| Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. |
AID26361 | pKa value was determined | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. |
AID234526 | Selectivity of compound towards human 5-HT1D receptor over human 5-HT1B receptor | 1999 | Journal of medicinal chemistry, Feb-25, Volume: 42, Issue:4
| 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents. |
AID4517 | Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. |
AID4499 | Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. |
AID16487 | Rate of clearance in rat was determined | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. |
AID1346264 | Human 5-HT1B receptor (5-Hydroxytryptamine receptors) | 2000 | Molecular pharmacology, Nov, Volume: 58, Issue:5
| Inverse agonism and constitutive activity as functional correlates of serotonin h5-HT(1B) receptor/G-protein stoichiometry. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |