| Assay ID | Title | Year | Journal | Article |
|---|
| AID94460 | Ability to stimulate Rb+ efflux from human K177 cell preparations containing human alpha4-beta2 receptors | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. |
| AID146168 | Stimulation of cation efflux in Nicotinic acetylcholine receptor alpha3-betaX subtype expressing IMR-32 cells | 1998 | Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
| Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist. |
| AID239324 | Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha2-beta2 | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. |
| AID91535 | The maximal efficacy relative to 100 uM nicotine | 1997 | Journal of medicinal chemistry, Jan-31, Volume: 40, Issue:3
| Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. |
| AID91525 | Ability to stimulate Rb+ efflux from human IMR-32 cell preparations containing human alpha3-betaX receptors | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. |
| AID225724 | Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells | 1998 | Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
| Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist. |
| AID91527 | Concentration required to elicit ganglionic receptors measured using [86Rb+] flux functional assay in a human neuroblastoma-derived IMR-32 cell line | 1997 | Journal of medicinal chemistry, Jan-31, Volume: 40, Issue:3
| Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. |
| AID145826 | Compound was evaluated for functional potency and efficacy at rat Nicotinic acetylcholine receptor subtype DA release at 1 uM | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
| AID239384 | Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2 | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. |
| AID146785 | Bindind affinity value obtained by measuring the displacement of radioligand [125I]alpha-bungarotoxin from K-28 cells stably express human Nicotinic acetylcholine receptor alpha7 | 1997 | Journal of medicinal chemistry, Jan-31, Volume: 40, Issue:3
| Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. |
| AID91534 | Maximum efficacy relative to 100(uM) (S)-nicotine for cell preparations containing alpha3-betaX IMR32 cells | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. |
| AID244249 | Selectivity against Nicotinic acetylcholine receptor subtypes alpha3-beta4 and alpha4-beta2 | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. |
| AID94463 | Maximum efficacy relative to 100(uM) (S)-nicotine for cell preparations containing alpha4-beta2 K177 cells | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. |
| AID145682 | Binding affinity against Nicotinic Acetylcholine Receptor was determined by measuring the displacement of [3H]cytisine from a preparation of whole rat brain. | 1996 | Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4
| Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. |
| AID239302 | Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta4 | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. |
| AID239326 | Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2 | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. |
| AID145519 | Nicotinic acetylcholine receptor binding activity was determined by ability to displace [3H]- (-) cytisine binding from whole rat brain synaptic membranes. | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
| Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework. |
| AID146299 | Compound was evaluated for functional potency and efficacy at human Nicotinic acetylcholine receptor alpha4-beta2 | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
| AID225732 | Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H](-)-cytisine in whole rat brain membranes. | 1998 | Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
| Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist. |
| AID239383 | Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4 | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. |
| AID146170 | Maximal efficacy relative to 100 uM nicotine in Nicotinic acetylcholine receptor alpha3-betaX subtype expressing IMR-32 cells | 1998 | Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
| Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist. |
| AID145359 | Compound was evaluated for functional potency and efficacy at human Nicotinic acetylcholine receptor ganglionic type on IMR-32 cells | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
| AID1328699 | Displacement of [3H]-cytisine from alpha4beta2-nACHR in rat whole brain | 2016 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 26, Issue:23
| Novel 5-substituted 3-hydroxyphenyl and 3-nitrophenyl ethers of S-prolinol as α4β2-nicotinic acetylcholine receptor ligands. |
| AID225710 | Binding affinity value obtained by measuring the displacement of radioligand [3H](-)-cytisine from a preparation of whole rat brain | 1997 | Journal of medicinal chemistry, Jan-31, Volume: 40, Issue:3
| Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. |
| AID145827 | compound was evaluated for functional potency and efficacy at rat Nicotinic acetylcholine receptor subtype DA release at 10 uM | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
| AID146472 | In vitro ability to displace [3H](-)-cytisine binding to whole rat brain membranes at Nicotinic acetylcholine receptor alpha4-beta2 | 2001 | Bioorganic & medicinal chemistry letters, Mar-12, Volume: 11, Issue:5
| Synthesis and structure-activity relationships of 5-substituted pyridine analogues of 3. |
| AID225729 | Maximal efficacy relative to 100 uM nicotine in human nAChR alpha4-beta2 expressing K177 cells | 1998 | Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
| Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist. |
| AID239325 | Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha2-beta4 | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |