Page last updated: 2024-12-11

azd 0328

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

spiro(1-azabicyclo(2.2.2)octane-3,2'(3H)-furo(2,3-b)pyridine): AZD-0328 is the (2'R)-isomer and D-tartrate salt; an alpha7 neuronal nicotinic receptor agonist; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	9794392
CHEMBL ID	2151437
SCHEMBL ID	1459640
MeSH ID	M0539230

Synonyms (26)

Synonym
ar-r23465xx
azd-0328
SCHEMBL1459640
spiro(1-azabicyclo(2.2.2)octane-3,2'(3h)-furo(2,3-b)pyridine)
2b218x5qiy ,
azd0328
azd 0328
unii-2b218x5qiy
spiro(1-azabicyclo(2.2.2)octane-3,2'(3'h)-furo(2,3-b)pyridine), (2'r)-
220099-91-2
bdbm50393243
chembl2151437 ,
azd 0328 [who-dd]
gtpl7697
(8r)-spiro[1-azabicyclo[2.2.2]octane-8,2'-3h-furo[5,4-b]pyridine]
(r)-(-)-spiro[1-azabicyclo[2.2.2]octane-3,2'(3'h)-furo[2,3-b]pyridine]
(r)-(-)-spiro[1-azabicyclo[2.2.2]octane-3,2' (3'h)-furo[2,3-b]pyridine]
OCKIPDMKGPYYJS-ZDUSSCGKSA-N ,
AKOS027324863
DB12145
spiro[1-azabicyclo[2.2.2]octane-3,2'(3'h)-furo[2,3-b]pyridine], (2'r)-
3'h-spiro[4-azabicyclo[2.2.2]octane-2,2'-furo[2,3-b]pyridine]
DTXSID40944616
Q17014648
(2r)-3h-1'-azaspiro[furo[2,3-b]pyridine-2,3'-bicyclo[2.2.2]octane]
(3r)-spiro[1-azabicyclo[2.2.2]octane-3,2'-3h-furo[2,3-b]pyridine]

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" Peak extracellular dopamine levels were reached 2h after dosing with AZD0328."	( Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. Christian, EP; Doherty, JJ; Gordon, JC; Gurley, D; Hudzik, T; Johnson, E; Jonak, G; Li, C; Maciag, C; Mrzljak, L; Piser, T; Quirk, MC; Smagin, GN; Smith, JS; Song, D; Sutton, EJ; Sydserff, S; Wang, Y; Widzowski, D, 2009)	0.35

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)	Ki	0.1400	0.0000	0.1117	3.5400	AID690411
Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)	Ki	0.0030	0.0022	1.7427	10.0000	AID1366573; AID690414
Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)	Ki	0.1400	0.0000	0.1157	3.5400	AID690411
5-hydroxytryptamine receptor 3A	Homo sapiens (human)	Ki	0.0120	0.0000	0.7411	9.9000	AID690410
Neuronal acetylcholine receptor subunit alpha-7	Rattus norvegicus (Norway rat)	Ki	0.0050	0.0000	0.7307	8.0000	AID1366572
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)	EC50 (µMol)	0.3400	0.1280	2.8018	8.9000	AID690413
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (74)

Process	via Protein(s)	Taxonomy
response to hypoxia	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
monoatomic ion transport	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
calcium ion transport	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
smooth muscle contraction	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
signal transduction	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
synaptic transmission, cholinergic	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
visual perception	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
sensory perception of sound	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
learning	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
memory	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
locomotory behavior	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
associative learning	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
visual learning	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of dopamine secretion	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
sensory perception of pain	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
vestibulocochlear nerve development	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
optic nerve morphogenesis	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
lateral geniculate nucleus development	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
central nervous system projection neuron axonogenesis	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
positive regulation of B cell proliferation	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of synaptic transmission, dopaminergic	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
positive regulation of dopamine secretion	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
monoatomic ion transmembrane transport	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
response to nicotine	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
behavioral response to nicotine	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
social behavior	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of dopamine metabolic process	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
B cell activation	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
response to cocaine	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of circadian sleep/wake cycle, REM sleep	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
response to ethanol	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
negative regulation of action potential	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of dendrite morphogenesis	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
nervous system process	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
cognition	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
membrane depolarization	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
regulation of synapse assembly	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
synaptic transmission involved in micturition	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
acetylcholine receptor signaling pathway	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
response to acetylcholine	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
chemical synaptic transmission	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
negative regulation of tumor necrosis factor production	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
response to hypoxia	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of protein phosphorylation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
monoatomic ion transport	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
calcium ion transport	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
intracellular calcium ion homeostasis	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
signal transduction	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
synaptic transmission, cholinergic	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
learning or memory	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
memory	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
short-term memory	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of cell population proliferation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
negative regulation of tumor necrosis factor production	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
monoatomic ion transmembrane transport	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
response to nicotine	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of MAPK cascade	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of angiogenesis	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
synapse organization	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
cognition	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
sensory processing	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of protein metabolic process	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
calcium ion transmembrane transport	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
acetylcholine receptor signaling pathway	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
dendritic spine organization	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
modulation of excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
dendrite arborization	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of long-term synaptic potentiation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of amyloid-beta formation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
negative regulation of amyloid-beta formation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
regulation of amyloid precursor protein catabolic process	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
response to amyloid-beta	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
response to acetylcholine	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
regulation of amyloid fibril formation	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of CoA-transferase activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
positive regulation of excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
regulation of membrane potential	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
chemical synaptic transmission	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
action potential	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
response to hypoxia	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
DNA repair	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
monoatomic ion transport	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
calcium ion transport	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
response to oxidative stress	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
signal transduction	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
chemical synaptic transmission	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
synaptic transmission, cholinergic	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
regulation of dopamine secretion	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
sensory perception of pain	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
monoatomic ion transmembrane transport	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
response to nicotine	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
behavioral response to nicotine	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
B cell activation	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
regulation of membrane potential	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
nervous system process	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
cognition	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
membrane depolarization	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
excitatory postsynaptic potential	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
inhibitory postsynaptic potential	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
acetylcholine receptor signaling pathway	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
serotonin receptor signaling pathway	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
monoatomic ion transmembrane transport	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
excitatory postsynaptic potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
inorganic cation transmembrane transport	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
regulation of presynaptic membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
chemical synaptic transmission	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
regulation of membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (20)

Process	via Protein(s)	Taxonomy
protein binding	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
ligand-gated monoatomic ion channel activity	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
acetylcholine receptor activity	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activity	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
acetylcholine binding	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
protein-containing complex binding	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
quaternary ammonium group binding	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
heterocyclic compound binding	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
amyloid-beta binding	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
monoatomic ion channel activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
calcium channel activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
protein binding	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
acetylcholine receptor activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
toxic substance binding	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
chloride channel regulator activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
acetylcholine binding	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
protein homodimerization activity	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
protein binding	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
ligand-gated monoatomic ion channel activity	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
acetylcholine receptor activity	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
acetylcholine-gated monoatomic cation-selective channel activity	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
acetylcholine binding	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
protein binding	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
serotonin-gated monoatomic cation channel activity	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
identical protein binding	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
serotonin binding	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
excitatory extracellular ligand-gated monoatomic ion channel activity	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (17)

Process	via Protein(s)	Taxonomy
plasma membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
external side of plasma membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
presynaptic membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
plasma membrane raft	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
cholinergic synapse	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
postsynaptic specialization membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
acetylcholine-gated channel complex	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
neuron projection	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
synapse	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
membrane	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
plasma membrane raft	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
postsynaptic membrane	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
postsynapse	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
acetylcholine-gated channel complex	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
neuron projection	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
synapse	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
external side of plasma membrane	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
membrane	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
dendrite	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
neuronal cell body	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
postsynaptic membrane	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
acetylcholine-gated channel complex	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
synapse	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
neuron projection	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
plasma membrane	Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)
plasma membrane	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
cleavage furrow	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
postsynaptic membrane	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
serotonin-activated cation-selective channel complex	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
synapse	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
plasma membrane	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
transmembrane transporter complex	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
neuron projection	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (12)

Assay ID	Title	Year	Journal	Article
AID690411	Binding affinity to human alpha4beta2 nAChR	2011	Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23	Discovery and development of α7 nicotinic acetylcholine receptor modulators.
AID730780	Ratio of drug level in brain to plasma in sc dosed rat after 30 mins	2013	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6	Discovery of a novel series of quinolone α7 nicotinic acetylcholine receptor agonists.
AID690413	Agonist activity at human alpha7 nAChR	2011	Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23	Discovery and development of α7 nicotinic acetylcholine receptor modulators.
AID690410	Binding affinity to human 5HT3A receptor	2011	Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23	Discovery and development of α7 nicotinic acetylcholine receptor modulators.
AID730782	Dissociation constant, pKa of the compound	2013	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6	Discovery of a novel series of quinolone α7 nicotinic acetylcholine receptor agonists.
AID690412	Agonist activity at human alpha7 nAChR relative to control	2011	Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23	Discovery and development of α7 nicotinic acetylcholine receptor modulators.
AID1366572	Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes after 2 hrs by topcount scintillation counting analysis	2017	Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22	Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor.
AID690414	Binding affinity to human alpha7 nAchR	2011	Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23	Discovery and development of α7 nicotinic acetylcholine receptor modulators.
AID730781	Permeability of the compound at pH 7.4 by PAMPA	2013	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6	Discovery of a novel series of quinolone α7 nicotinic acetylcholine receptor agonists.
AID1366573	Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes after 2 hrs by topcount scintillation counting analysis	2017	Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22	Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor.
AID730779	Efflux ratio of the compound in human Caco2 cells	2013	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6	Discovery of a novel series of quinolone α7 nicotinic acetylcholine receptor agonists.
AID1346583	Human nicotinic acetylcholine receptor alpha7 subunit (Nicotinic acetylcholine receptors)	2011	Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23	Discovery and development of α7 nicotinic acetylcholine receptor modulators.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (14.29)	29.6817
2010's	6 (85.71)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (14.29%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
sb 206553 SB 206553: a high-affinity 5-HT(2C/2B) antagonist; structure given in first source	3.16	1	pyrroloindole
levodopa Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.. L-dopa : An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease	2.17	1	amino acid zwitterion; dopa; L-tyrosine derivative; non-proteinogenic L-alpha-amino acid	allelochemical; antidyskinesia agent; antiparkinson drug; dopaminergic agent; hapten; human metabolite; mouse metabolite; neurotoxin; plant growth retardant; plant metabolite; prodrug
quinuclidines Quinuclidines: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms and contains an amine group.	2.99	4	quinuclidines; saturated organic heterobicyclic parent
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	2.17	1	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
tropisetron Tropisetron: An indole derivative and 5-HT3 RECEPTOR antagonist that is used for the prevention of nausea and vomiting.. tropisetron : An indolyl carboxylate ester obtained by formal condensation of the carboxy group of indole-3-carboxylic acid with the hydroxy group of tropine.	3.16	1	indolyl carboxylic acid
ar-r 17779 AR-R 17779: structure in first source	3.16	1
ssr180711 SSR180711: a selective alpha7 acetylcholine nicotinic receptor (n-AChRs) partial agonist; structure in first source	3.16	1
evp-6124 [no description available]	3.16	1

Condition	Relationship Strength	Studies
Autosomal Dominant Juvenile Parkinson Disease [description not available]	2.17	1
Dyskinesia, Medication-Induced [description not available]	2.17	1
Dyskinesia, Drug-Induced Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)	2.17	1
Parkinsonian Disorders A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.	2.17	1

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