| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1127394 | Inhibition of carbachol-induced contraction of Sprague-Dawley rat tracheal rings after 30 mins by isometric tension technique | 2014 | Journal of natural products, Apr-25, Volume: 77, Issue:4
| Potent airway smooth muscle relaxant effect of cynatratoside B, a steroidal glycoside isolated from Cynanchum stauntonii. |
| AID218845 | Change in Gibb's free energy at Low affinity beta-2-adrenoceptor in the membranes of bovine skeletal muscle preparation | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Mapping of the beta 2-adrenoceptor on Chang liver cells. Differences between high- and low-affinity receptor states. |
| AID1598554 | Displacement of [3H]-CGP-12177 from human beta2-adrenergic receptor expressed in CHO cells after 60 mins by radioligand competition binding assay | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598564 | Agonist activity at beta2-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring Rluc2-117-GalphaS/GFP10-Ggamma/Gbeta1 assessed as activation of GalphaS incubated for 5 mins in presence of coelenterazine 400a by BRET assay | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598553 | Displacement of [3H]-CGP-12177 from murine beta1-adrenergic receptor expressed in HEK293T cells after 60 mins by radioligand competition binding assay | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598555 | Agonist activity at beta1-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring Rluc2-117-GalphaS/GFP10-Ggamma/Gbeta1 assessed as activation of GalphaS incubated for 5 mins in presence of coelenterazine 400a by BRET assay relative to i | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598561 | Agonist activity at beta1-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of GRK5 and coelenterazine 400a by BRET | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1073604 | Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay | 2014 | Journal of medicinal chemistry, Jan-09, Volume: 57, Issue:1
| Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing. |
| AID40844 | Activity for Beta-2 adrenergic receptor was assessed from effect on relaxation of guinea pig trachea. | 1995 | Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
| Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. |
| AID1073602 | Agonist activity at human beta1 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay | 2014 | Journal of medicinal chemistry, Jan-09, Volume: 57, Issue:1
| Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing. |
| AID1598562 | Agonist activity at beta1-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of GRK5 and coelenterazine 400a by BRET | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1073601 | Agonist activity at human beta3 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay | 2014 | Journal of medicinal chemistry, Jan-09, Volume: 57, Issue:1
| Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing. |
| AID1598563 | Agonist activity at beta2-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring Rluc2-117-GalphaS/GFP10-Ggamma/Gbeta1 assessed as activation of GalphaS incubated for 5 mins in presence of coelenterazine 400a by BRET assay relative to i | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID391614 | Displacement of [125I](-)-iodopindolol from adrenergic beta2 receptor in Syrian hamster DDT1 MF2 cells | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands. |
| AID42046 | Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium. | 1995 | Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
| Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. |
| AID1598567 | Agonist activity at beta2-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of GSK2 and coelenterazine 400a by BRET | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598556 | Agonist activity at beta1-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring Rluc2-117-GalphaS/GFP10-Ggamma/Gbeta1 assessed as activation of GalphaS incubated for 5 mins in presence of coelenterazine 400a by BRET assay | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598558 | Agonist activity at beta1-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of coelenterazine 400a by BRET assay | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598570 | Agonist activity at beta2-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of GSK5 and coelenterazine 400a by BRET | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID218847 | Change in Gibb's free energy at High affinity beta2- adrenoceptor in Chang living cells. | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Mapping of the beta 2-adrenoceptor on Chang liver cells. Differences between high- and low-affinity receptor states. |
| AID391616 | Agonist activity at adrenergic beta2 receptor in Syrian hamster DDT1 MF2 cells assessed as stimulation of cAMP accumulation by radioimmunoassay in presence of 1 uM DPCPX | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands. |
| AID1598568 | Agonist activity at beta2-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of GSK2 and coelenterazine 400a by BRET | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598560 | Agonist activity at beta1-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of GRK2 and coelenterazine 400a by BRET | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID218848 | Change in Gibb's free energy at Low affinity beta-2-adrenoceptor in the Chang living cells | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Mapping of the beta 2-adrenoceptor on Chang liver cells. Differences between high- and low-affinity receptor states. |
| AID391626 | Selectivity ratio, Ki for adrenergic beta2 receptor to EC50 for adrenergic beta2 receptor in Syrian hamster DDT1 MF2 cells | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands. |
| AID1148091 | Bronchodilatory activity in anesthetized dog assessed as inhibition of pilocarpine-induced bronchospasms at 16 to 32 ug/kg administered through aerosol 15 mins post challenge measured up to 1 hr | 1977 | Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
| Prostaglandins and congeners. 16. Synthesis and bronchodilator activity of dl-11-doexy-3-thiaprostaglandins. |
| AID1598557 | Agonist activity at beta1-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of coelenterazine 400a by BRET assay re | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598569 | Agonist activity at beta2-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of GSK5 and coelenterazine 400a by BRET | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598565 | Agonist activity at beta2-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of coelenterazine 400a by BRET assay re | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598566 | Agonist activity at beta2-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of coelenterazine 400a by BRET assay | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1598559 | Agonist activity at beta1-adrenergic receptor (unknown origin) expressed in HEK293T cells harboring GFP/Rluc2-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment incubated for 5 mins in presence of GRK2 and coelenterazine 400a by BRET | 2019 | Journal of medicinal chemistry, 05-23, Volume: 62, Issue:10
| Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |