| Assay ID | Title | Year | Journal | Article |
|---|
| AID4072 | In vitro displacement of [3H]8-OH-DPAT binding to rat hippocampal 5-hydroxytryptamine 1A receptor | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18
| 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions. |
| AID61367 | Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390 | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
| AID460125 | Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in CHO cells by liquid scintillation counting | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist. |
| AID313107 | Inhibition of rat midbrain dopaminergic neuron firing | 2007 | Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2
| Advances in development of dopaminergic aporphinoids. |
| AID411967 | Displacement of [3H]nemonapride from dopamine D2 receptor in rat forebrain | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1
| Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines. |
| AID170094 | In vivo accumulation of 5HTP in percent of saline control was determined in cortex of reserpine pretreated rat at dose of 3.2 uM/kg | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18
| 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions. |
| AID317241 | Displacement of [3H]neomonapride from dopamine D2 receptor in rat striatum | 2008 | Journal of medicinal chemistry, Feb-28, Volume: 51, Issue:4
| Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity. |
| AID170106 | In vivo accumulation of 5HTP in percent of saline control was determined in striatum of reserpine pretreated rat at dose of 3.2 uM/kg | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18
| 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions. |
| AID340034 | Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphines. |
| AID317242 | Selectivity ratio of rat dopamine D2 receptor to rat dopamine D1 receptor | 2008 | Journal of medicinal chemistry, Feb-28, Volume: 51, Issue:4
| Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity. |
| AID231230 | Potency of compound against D1 receptor to D2 receptor was determined | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
| AID608546 | Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells at 10 uM after 50 mins by beta liquid scintillation counter | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile. |
| AID313111 | Displacement of [3H]SCH-23390 from rat dopamine D1 receptor | 2007 | Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2
| Advances in development of dopaminergic aporphinoids. |
| AID45983 | Inhibition of [3H]spiroperidol binding to calf caudate membrane preparation (p4) | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12
| Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines. |
| AID569896 | Displacement of [3H]SCH23390 from dopamine D2 receptor low binding site in Sprague-Dawley rat striatum by scintillation counting | 2011 | ACS medicinal chemistry letters, Mar-10, Volume: 2, Issue:3
| Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors |
| AID387701 | Displacement of [3H]SCH23390 from rat 5HT1A receptor expressed in CHO cells | 2008 | Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
| N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. |
| AID569898 | Displacement of [3H]domperidone from human cloned dopamine D3 receptor expressed in mouse CCL1-3 cells by scintillation counting | 2011 | ACS medicinal chemistry letters, Mar-10, Volume: 2, Issue:3
| Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors |
| AID460126 | Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist. |
| AID387703 | Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
| N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. |
| AID63012 | Binding affinity against dopamine agonist sites from rat brain corpus striatal preparations using [3H]ADTN | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
| AID34458 | Dopamine sensitive adenylate cyclase activity (stimulation) in homogenates of rat brain striatal tissue was assessed at 50 uM; + = <40% increase of cAMP above basal activity | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12
| Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines. |
| AID411968 | Selectivity ratio of Ki for dopamine D1 receptor to Ki for dopamine D2 receptor in rat forebrain | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1
| Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines. |
| AID64306 | Displacement of [3H]raclopride from human Dopamine receptor D2A | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18
| 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions. |
| AID64953 | Binding affinity against Dopamine receptor D2 from rat brain corpus striatal preparations using [3H]spiperone | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
| AID313112 | Displacement of [3H]raclopride from rat dopamine D2 receptor | 2007 | Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2
| Advances in development of dopaminergic aporphinoids. |
| AID170100 | In vivo accumulation of 5HTP in percent of saline control was determined in limbic forebrain of reserpine pretreated rat at dose of 3.2 uM/kg | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18
| 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions. |
| AID340035 | Displacement of [3H]neomonapride from dopamine D2 receptor in rat corpus striatum | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphines. |
| AID63013 | Compound was evaluated for its ability to inhibit Striatal Dopamine receptor in rat brain through radioreceptor assay carried out with agonist ligand. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| R and S enantiomers of 11-hydroxy- and 10,11-dihydroxy-N-allylnoraporphine: synthesis and affinity for dopamine receptors in rat brain tissue. |
| AID168350 | Stereotyped behavior in rat induced by Aporphines after ip administration at 0.3 mg/kg dose | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
| AID569902 | Displacement of [3H]domperidone from human cloned dopamine D3 receptor high binding site expressed in mouse CCL1-3 cells by scintillation counting | 2011 | ACS medicinal chemistry letters, Mar-10, Volume: 2, Issue:3
| Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors |
| AID608551 | Displacement of [3H]ketanserin from 5-HT2A receptor expressed in CHO cells at 10 uM after 50 mins by beta liquid scintillation counter | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile. |
| AID317240 | Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum | 2008 | Journal of medicinal chemistry, Feb-28, Volume: 51, Issue:4
| Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity. |
| AID569897 | Displacement of [3H]domperidone from dopamine D2 receptor high binding site in Sprague-Dawley rat striatum by scintillation counting | 2011 | ACS medicinal chemistry letters, Mar-10, Volume: 2, Issue:3
| Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors |
| AID340037 | Selectivity ratio of Ki for dopamine D2 receptor to Ki for dopamine D1 receptor in rat corpus striatum | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| Synthesis and binding studies of 2-O- and 11-O-substituted N-alkylnoraporphines. |
| AID61505 | Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390 | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| R and S enantiomers of 11-hydroxy- and 10,11-dihydroxy-N-allylnoraporphine: synthesis and affinity for dopamine receptors in rat brain tissue. |
| AID168351 | Stereotyped behavior in rat induced by Aporphines after ip administration at 0 mg/kg dose | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
| AID170341 | Effect (3 mg/kg) on motor arousal induced by apomorphine | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
| AID173457 | Effect (3 mg/kg) on motor arousal induced by apomorphine (0.3 mg/kg) expressed as percent control | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
| AID387702 | Displacement of [3H]Spiperone from human 5HT2A receptor expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
| N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. |
| AID569900 | Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assay | 2011 | ACS medicinal chemistry letters, Mar-10, Volume: 2, Issue:3
| Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors |
| AID170254 | In vivo accumulation of DOPA in percent of saline control was determined in striatum of reserpine pretreated rat at dose of 3.2 uM/kg | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18
| 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions. |
| AID569899 | Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assay | 2011 | ACS medicinal chemistry letters, Mar-10, Volume: 2, Issue:3
| Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors |
| AID387704 | Displacement of [3H]ketanserin from human dopamine D2 receptor expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18
| N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. |
| AID168353 | Stereotyped behavior in rat induced by Aporphines after ip administration at 3.0 mg/kg dose | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
| AID170112 | In vivo accumulation of DOPA in percent of saline control was determined in cortex of reserpine pretreated rat at dose of 3.2 uM/kg | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18
| 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions. |
| AID65276 | Compound was evaluated for its ability to inhibit Dopamine receptor D2 in rat striatum using [3H]spiperone | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| R and S enantiomers of 11-hydroxy- and 10,11-dihydroxy-N-allylnoraporphine: synthesis and affinity for dopamine receptors in rat brain tissue. |
| AID460127 | Displacement of [3H]spiperone from dopamine D2 receptor expressed in HEK293 cells by liquid scintillation counting | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist. |
| AID313108 | Inhibition of tyrosine hydroxylase | 2007 | Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2
| Advances in development of dopaminergic aporphinoids. |
| AID226743 | Potency ratio calculated from the ratio of D2 to that of D1 receptors | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| R and S enantiomers of 11-hydroxy- and 10,11-dihydroxy-N-allylnoraporphine: synthesis and affinity for dopamine receptors in rat brain tissue. |
| AID411966 | Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain | 2009 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1
| Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines. |
| AID168352 | Stereotyped behavior in rat induced by Aporphines after ip administration at 1.0 mg/kg dose | 1988 | Journal of medicinal chemistry, Jul, Volume: 31, Issue:7
| Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. |
| AID170248 | In vivo accumulation of DOPA in percent of saline control was determined in limbic forebrain of reserpine pretreated rat at dose of 3.2 uM/kg | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18
| 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions. |
| AID45982 | Inhibition of [3H]apomorphine binding to calf caudate membrane preparation (p4) | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12
| Aporphines, 36. Dopamine receptor interactions of trihydroxyaporphines. Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2,10,11-trihydroxyaporphines in comparison with other hydroxylated aporphines. |
| AID313114 | Displacement of [3H]8-OH-DPAT from rat 5HT1A receptor | 2007 | Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2
| Advances in development of dopaminergic aporphinoids. |
| AID61514 | In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1 | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18
| 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |