| ID Source | ID |
|---|---|
| PubMed CID | 90116945 |
| CHEMBL ID | 4206836 |
| SCHEMBL ID | 15667328 |
| MeSH ID | M000611620 |
| Synonym |
|---|
| S7964 |
| CS-5129 |
| HY-18997 |
| plx7904 , |
| SCHEMBL15667328 |
| AC-35385 |
| n'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-n-ethyl-n-methylsulfuric diamide |
| plx-7904 |
| pb04 |
| 5-(2-cyclopropylpyrimidin-5-yl)-3-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluorobenzoyl]-1h-pyrrolo[2,3-b]pyridine |
| 1393465-84-3 |
| AKOS030526477 |
| ({3-[5-(2-cyclopropylpyrimidin-5-yl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}sulfamoyl)(ethyl)methylamine |
| plx7904(pb04) |
| BCP18248 |
| EX-A2872 |
| bdbm317744 |
| us9624213, compound p-0240 |
| CCG-269789 |
| sulfamide, n'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-n-ethyl-n-methyl- |
| Q27456931 |
| n'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-n-ethyl-n-methyl-sulfamide |
| A901658 |
| MS-29512 |
| CHEMBL4206836 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| PPM1D protein | Homo sapiens (human) | Potency | 18.5569 | 0.0052 | 9.4661 | 32.9993 | AID1347411 |
| Interferon beta | Homo sapiens (human) | Potency | 18.5569 | 0.0033 | 9.1582 | 39.8107 | AID1347411 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase B-raf | Homo sapiens (human) | IC50 (µMol) | 0.0101 | 0.0001 | 0.2800 | 7.5890 | AID1380308; AID1380310 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| extracellular space | Interferon beta | Homo sapiens (human) |
| extracellular region | Interferon beta | Homo sapiens (human) |
| nucleus | Serine/threonine-protein kinase B-raf | Homo sapiens (human) |
| cytosol | Serine/threonine-protein kinase B-raf | Homo sapiens (human) |
| plasma membrane | Serine/threonine-protein kinase B-raf | Homo sapiens (human) |
| neuron projection | Serine/threonine-protein kinase B-raf | Homo sapiens (human) |
| intracellular membrane-bounded organelle | Serine/threonine-protein kinase B-raf | Homo sapiens (human) |
| cell body | Serine/threonine-protein kinase B-raf | Homo sapiens (human) |
| presynapse | Serine/threonine-protein kinase B-raf | Homo sapiens (human) |
| cytosol | Serine/threonine-protein kinase B-raf | Homo sapiens (human) |
| mitochondrion | Serine/threonine-protein kinase B-raf | Homo sapiens (human) |
| plasma membrane | Serine/threonine-protein kinase B-raf | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1380310 | Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by AlphaScreen assay | 2018 | Journal of medicinal chemistry, 07-26, Volume: 61, Issue:14 | Current Insights of BRAF Inhibitors in Cancer. |
| AID1380308 | Inhibition of N-terminal His-tagged BRAF V600E mutant (unknown origin) expressed in baculovirus infected insect cells co-expressing CDC37 using biotinylated-MEK as substrate by AlphaScreen assay | 2018 | Journal of medicinal chemistry, 07-26, Volume: 61, Issue:14 | Current Insights of BRAF Inhibitors in Cancer. |
| AID1380335 | Cytotoxicity against human A375 cells harboring BRAF V600E mutant | 2018 | Journal of medicinal chemistry, 07-26, Volume: 61, Issue:14 | Current Insights of BRAF Inhibitors in Cancer. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (21.93) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (33.33%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (66.67%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||